Surgical approach of large-sized hepatic tumors

Universitatea de Medicină “Gr.T.Popa”, Spitalul Universitar “Sf.Spiridon”, Iaşi, România, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Există încă numeroase controverse privind managementul tumorilor hepatice voluminoase. Scopul studiului este să evalueze retrospectiv efectele dimensiunii şi diferitelor tipuri de rezecție chirurgicală asupra evoluției postoperatorii precoce. Material şi metode: Pacienții înregistrați consecutiv în baza de date a Clinicii I Chirurgie în perioada 2000-2014 cu tumori hepatice primitive şi secundare au fost împărțiți în două grupuri în funcție de dimensiunea tumorii hepatice (grupul 1 – >10 cm şi grupul 2 – <10 cm) şi de tipul de procedură utilizată. Rezultate: Durata operației şi cantitatea de sânge pierdută intraoperator au fost semnificativ mai mari (p=0,01 şi, respectiv, p=0,03) pentru tumorile din grupul 1. Evoluția postoperatorie a fost similară pentru rezecții anatomice şi non-anatomice. Concluzii: Strategiile de management şi progresele tehnologice din ultima perioadă au îmbunătățit rezultatele tratamentului chirurgical pentru pacienții cu carcinom hepatocelular de mari dimensiuni.Introduction: Controversies still exist regarding the management of large-sized hepatic tumors. The aim of the study is to retrospectively evaluate the effects of the size and different types of surgical resection to the early postoperative outcome. Material and methods: Consecutive patients registered in our database from 2000 to 2014 with primitive or metastatic liver tumors were divided in 2 groups according to the size of the hepatic tumor (Group 1 – ≥10 cm and Group 2 – <10 cm) and the selected operative procedure used. Results: The operation time was significantly longer (p=0.01) and the amount of blood loss was significantly higher (p=0.03) in liver tumors ≥10 cm. Surgical outcome after anatomic or non-anatomic resection was similar. Conclusion: The recent management strategy and technological advances improved the results of surgical treatment for patients with large hepatocellular carcinoma

Facile Method for Obtaining Gold-Coated Polyester Surfaces with Antimicrobial Properties

The antimicrobial and antifungal activity of polymers used in medical devices has been extensively studied due to the growing impact of hospital-related infections in patients. The ideal biocidal polymeric materials should be very effective in the microorganism’s inhibition, not toxic to the human body, and environmentally friendly. In this context, this work is aimed at obtaining antimicrobial and antifungal properties at the polyester film surfaces without introducing toxic effects. Poly (ethylene terephthalate) (PET) films were functionalized with Ar plasma and then immersed in a solution containing gold nanoparticles (AuNps). The results demonstrated the appearance of the hydrophilic groups on the film surface after modification of PET film by plasma Ar treatment and the formation of the polar groups such as C=O, COO-, and OH, which then reacted with AuNps. The changes induced in the treated polymer samples were investigated in terms of AuNp adsorption efficiency on polyester film by contact angle, profilometry, Scanning Electron Microscopy (SEM), Attenuated Total Reflectance Spectroscopy-Fourier Transform Infrared (ATR-FTIR), and X-ray Photoelectron Spectroscopy (XPS) measurements. The morphological and structural analyses have shown a good adhesion of AuNps at treated film surfaces. The results of biocompatibility antimicrobial and antifungal tests proved the nontoxic behavior of the sample and its good antimicrobial and antifungal activity

Emergency pancreaticoduodenectomy in non-trauma patients

Spitalul Universitar “Sf.Spiridon“, Universitatea de Medicină şi Farmacie “Gr.T.Popa”, Iaşi, România, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Duodenopancreatectomia cefalică este una dintre cele mai complexe proceduri chirurgicale, asociată cu o rată a morbidității și a mortalității semnificativ crescute. Duodenopancreatectomia în urgență reprezintă 1-2% din totalitatea indicațiilor și este rezervată pacienților cu traumatisme pancreaticoduodenale, sîngerări sau perforații la acest nivel. Material și metode: Vom raporta 6 cazuri avînd diferite patologii, dar cu aceeași indicație terapeutică: duodenopancreatectomia cefalică în urgență. În două cazuri s-a optat pentru un abord posterior cu disecția inițială a mezopancreasului. Rezultate: Evoluția postoperatorie a fost favorabilă în 4 cazuri, iar doi pacienți au decedat secundar insuficienței multiple de organ. Concluzii: Duodenopancreatectomia cefalică este o intervenție chirurgicală vitală în cazul pacienților care nu beneficiază de proceduri intervenționale minim invazive sau în cazul în care intervențiile chirurgicale minimale pot fi riscante.Introduction: Pancreaticoduodenectomy (PD) is one of the most complex surgical procedures, associated with substantial operative morbidity and mortality rates. Emergent pancreaticoduodenectomy (EPD) represents 1-2% of pancreatoduodenectomy indications and is an uncommon surgical procedure performed to treat patients with acute pancreaticoduodenal trauma, bleeding or perforation. Material and methods: We report 6 surgical interventions with different non-traumatic pathologies, but the same surgical choice of treatment: emergent pancreaticoduodenectomy. The posterior approach, with initial mesopancreatic dissection was chosen in two cases. Results: We registered two postoperative deaths caused by multiple organ dysfunction syndrome and in the other patients the early postoperative outcomes were uneventful. Conclusion: Emergency pancreaticoduodenectomy is a life-saving procedure whenever local situation cannot be handled by less invasive interventional measures, as well as when limited surgery seems unsafe

Regio- and stereoselective synthesis of (+)-6-ketoeuryfuran, (+)-6-ketowinterin, and (-)-7-ketoeuryfuran from accessible labdane diterpenoids (+)-larixol and (-)-sclareol

Starting from (+)-larixol and (-)-sclareol, new syntheses of (+)-6-ketoeuryfuran, (+)-6-ketowinterin, and (-)-7-ketoeuryfuran have been elaborated in high yields. (+)-6-Ketowinterin was synthesized for the first time. Both euryfurans are excellent starting materials for the synthesis of important polyfunctional biologically active drimanic compounds. (C) 2012 Elsevier Ltd. All rights reserved