Transistors

Contains reports on eight research projects.Lincoln Laboratory under Contract AF19(122)-45

Transistors

Contains reports on six research projects

Glycan labeling strategies and their use in identification and quantification

Most methods for the analysis of oligosaccharides from biological sources require a glycan derivatization step: glycans may be derivatized to introduce a chromophore or fluorophore, facilitating detection after chromatographic or electrophoretic separation. Derivatization can also be applied to link charged or hydrophobic groups at the reducing end to enhance glycan separation and mass-spectrometric detection. Moreover, derivatization steps such as permethylation aim at stabilizing sialic acid residues, enhancing mass-spectrometric sensitivity, and supporting detailed structural characterization by (tandem) mass spectrometry. Finally, many glycan labels serve as a linker for oligosaccharide attachment to surfaces or carrier proteins, thereby allowing interaction studies with carbohydrate-binding proteins. In this review, various aspects of glycan labeling, separation, and detection strategies are discussed

A Tribute to Sidney W. Bijou, Pioneer in Behavior Analysis and Child Development: Key Works That Have Transformed Behavior Analysis in Practice

Sidney W. Bijou's contributions to the practice of behavior analysis spanned nearly 7 decades, and they continue to influence what is considered “best practice” in our field today. By extending basic behavioral phenomena conducted with nonhuman animals to children in laboratory and naturalistic settings, Bijou's early research sparked a watershed of similar extensions. More importantly, Bijou's approach has led to a greater understanding of child development and behavior. This tribute will highlight what may be three of Bijou's most significant contributions to practice, namely his studies on (a) programmed instruction for children with developmental disabilities (Bijou, Birnbrauer, Kidder, & Tague, 1966), (b) children's responding under schedules of reinforcement and extinction (Bijou, 1957), and (c) the use of descriptive analysis to identify functional relations (Bijou, Peterson, & Ault, 1968)