1-[2-(4-methyl-7-coumarinyloxy)ethyl]-4-(5-{1-[2-(4-methyl-7-coumarinyloxy)ethyl]-1h-1, 2, 3-triazol-4-yl}pentyl)-1h-1, 2, 3-triazole

Nature often produces compounds with a high degree of symmetry to reduce structural information and complexity. Synthesis of identical twin drugs, through the linkage of two identical pharmacophoric entities, is a classical strategy to produce more potent and/or selective drugs. Herein, two units of the privileged core of the coumarin hymecromone were linked together using “click chemistry”. Synthesis of 1-[2-(4-Methyl-7-coumarinyloxy)ethyl]-4-(5-{1-[2-(4-methyl- 7-coumarinyloxy)ethyl]-1H-1, 2, 3-triazol-4-yl}pentyl)-1H-1, 2, 3-triazole was achieved by coupling of two identical units of an azido coumarin with a symmetrical alkine using copper(I)-catalyzed alkyne-azide cycloaddition reaction, in good yields and with complete regioselectivity. © 2016 by the authors; licensee MDPI, Basel, Switzerland.2016

Measurement of total and partial photon proton cross-sections at 180-GeV center-of-mass energy

Photon proton cross sections for elastic light vector meson production, sigma(el)gammap, inelastic diffractive production, sigma(d)gammap, non-diffractive production, sigma(nd)gammap, as well as the total cross section, sigma(tot)gammap, have been measured at an average gammap center of mass energy of 180 GeV with the ZEUS detector at HERA. The resulting values are sigma(el)gammap = 18 +/- 7 mub, sigma(d)gammap = 33 +/- 8 mub, sigma(nd)gammap = 91 +/- 11 mub, and sigma(tot)gammap = 143 +/- 17 mub, where the errors include statistical and systematic errors added in quadrature