Projekt "Jää ja tule laul" : LARP kui kiusamise ennetamise viis noorte seas

http://tartu.ester.ee/record=b2646395~S1*es

Should Healthcare Organisations Offer Ongoing Rehabilitation Services for Patients Undergoing Haematopoietic Cell Transplant? A Narrative Review

Purpose: Hematopoietic stem cell transplant (HSCT) patients can suffer from long-term transplant-related complications that affect their quality of life and daily activities. This study, a narrative review, aims to report the impact of HCT complications, the benefits of rehabilitation intervention, the need for long-term care and highlights the research gap in clinical trials involving rehabilitation. Design/methodology/approach: A comprehensive search strategy was performed on several databases to look for relevant articles published from 1998 to 2018. Articles published in English with the following terms were used: hematopoietic stem cell transplant, chronic graft-versus-host disease, rehabilitation, exercise, physical therapy, occupational therapy. A patient/population, intervention, comparison, and outcomes (PICO) framework was employed to ensure that the search strategies were structured and precise. Study year, design, outcome, intervention, sample demographics, setting and study results were extracted. Findings: Of the 1,411 records identified, 51 studies underwent title/abstract screening for appropriateness, 30 were reviewed in full, and 19 studies were included in the review. The review found that, for the majority of patients who underwent HSCT and developed treatment-related complications, rehabilitation exercises had a positive impact on their overall quality of life. However, exercise prescription in this patient group has not always reflected the scientific approach; there is a lack of high-quality clinical trials in general. The review also highlights the need to educate healthcare policymakers and insurance companies responsible for rationing services to recognise the importance of offering long-term follow-up care for this patient group, including rehabilitation services. Practical implications: A large number of HSCT patients require long-term follow-up from a multidisciplinary team, including rehabilitation specialists. It is important for healthcare policymakers and insurance companies to recognise this need and take the necessary steps to ensure that HSCT patients receive adequate long-term care. This paper also highlights the urgent need for high-quality rehabilitation trials to demonstrate the feasibility and importance of rehabilitation teams. Originality/value: Healthcare policymakers and insurance companies need to recognise that transplant patients need ongoing physiotherapy for early identification of any functional impairments and appropriate timely intervention

Application of seismic methods for estimating the perspective of oil and gas potential of the sediments of the paleozoic basement of the Western Siberian plate

Актуальность исследования обусловлена необходимостью увеличения сырьевого потенциала месторождений Западной Сибири, приуроченных к доюрским отложениям, с минимальными затратами на дополнительную разведку. Такая возможность связана с резким развитием технологий сейсмической разведки в последние годы. Современная сейсмическая 3D съёмка позволяет прослеживать характерные особенности геологического строения палеозойских отложений, которые было невозможно различить на профильных сейсмических разрезах 2D. Для получения наиболее объективных результатов целесообразно применение комплекса методов, включающих, помимо сейсморазведки, методы геофизических исследований скважин. Цель: выделить перспективные участки для освоения доюрского комплекса по данным сейсморазведки на примере одного из месторождений Томской области, приуроченных к палеозойскому фундаменту Западной Сибири. Объекты: отложения палеозойского фундамента юго-восточной части Западно-Сибирской плиты, характеризующиеся сложным вещественным составом горных пород, складчато-блоковым тектоническим строением, наличием естественной трещиноватости карбонатных коллекторов, порово-каверново-трещиным типом коллектора. Методы: специальный анализ сейсмических атрибутов; сейсмический фациальный анализ; комплексирование сейсмических методов и результатов интерпретации скважинных данных. Результаты. Выполнен анализ пространственного изменения сейсмических атрибутов, на основе которого выделены зоны повышенной трещиноватости и проведена оценка преобладающего направления систем трещин. Применение сейсмофациального анализа позволило выявить приуроченность участков повышенной плотности трещин к породам с улучшенными коллекторскими свойствами. Построенная схема перспектив нефтегазоносности палеозойских отложений на примере одного из месторождений Западной Сибири удовлетворительно согласуется с результатами геофизических исследований скважин и данными лабораторного изучения керна.The relevance of the research is caused by the need to increase the raw potential of fields in Western Siberia, confined to pre-Jurassic deposits, with minimal additional exploration costs. This possibility is associated with the dramatic development of seismic survey technology in recent years. Modern 3D seismic survey allows tracing the characteristic features of the geological structure of the Paleozoic deposits, which were impossible to distinguish on 2D profile seismic sections. To obtain the most objective results, it is advisable to use a set of methods that include, in addition to seismic prospecting, methods of well logging. The main aim of the research is to identify promising areas for development of the pre-Jurassic complex according to seismic data on the example of one of the fields in Tomsk region, confined to the Paleozoic basement of Western Siberia. Objects of research are deposits of the Paleozoic basement of the southeastern part of the West Siberian Plate, characterized by a complex material composition of rocks, a folded-block tectonic structure, the presence of natural fracturing of carbonate reservoirs, and porous-vuggy-fractured reservoir rock. Methods: seismic attribute analysis, seismic facies analysis, integration of seismic and results of well data interpretation. Results. The authors have carried out the analysis of spatial changes in seismic attributes, on the basis of which zones of increased fracturing were identified and the prevailing direction of fracture systems was assessed. The use of seismic facies analysis allowed identifying the confinement of areas of increased density of fractures to rocks with improved reservoir properties. The scheme developed for the oil and gas potential of the Paleozoic deposits on the example of one of the fields in Western Siberia is in satisfactory agreement with the results of geophysical well studies and data from a laboratory core study

Statistical justification of the choice of attributive parameters for forecasting pre-jurassic reservoirs according to seismic data

Актуальность исследования обусловлена необходимостью увеличения степени достоверной оценки геологического строения сложнопостроенных коллекторов при наличии малого набора геолого-геофизической информации, что представляет неоднозначность в прогнозировании и выделении геологических объектов. В последние десятилетия компании широко применяют различные классификационные алгоритмы в процессе обработки всего комплекса данных для уменьшения неопределенностей геологической интерпретации. Одним из подходов является применение классификационных методов к сейсмическому сигналу, которые разделяют исследуемый объект на однородные по ряду признаков области, где также совместно используют данные геофизических исследований скважин и лабораторных исследований керна, что подразумевает комплексирование информации. Комплексная интерпретация сейсмических и скважинных данных позволяет прогнозировать на качественном уровне литофациальную изменчивость на локальных участках, что способствует более рациональному размещению эксплуатационных скважин. Цель исследования заключается в рассмотрении подходов анализа достоверной оценки и прогноза фациального строения при поиске перспективных объектов для наиболее оптимального расположения эксплуатационных скважин при планировании бурения, с учетом постоянно пополняемой и обновляемой геологической информации о пласте. Объектом исследования являются отложения палеозойского фундамента юго-восточной части Западно-Сибирской плиты, которые представляют породы различного вещественного состава, включая карбонатные разности. Методы исследования включают статистический анализ сейсмической информации и геолого-геофизических данных. В результате исследования выполнен статистический анализ пространственного изменения фациальной обстановки, на основе которого выделены достоверные зоны наличия определенной фации. Предложенная стратегия прогнозирования перспектив нефтегазоносности палеозойских отложений на примере одного из месторождений Западной Сибири способствовала выделению перспективных зон для будущего планирования расположения скважин.The relevance of the research is caused by the need to increase the degree of reliable assessment of the geological structure of complex reservoirs in the presence of a small set of geological and geophysical information, which is ambiguous in predicting and identifying geological objects. In recent decades, companies have widely used various classification algorithms in processing the entire complex of data to reduce the uncertainties of geological interpretation. One of the approaches is application of classification methods to a seismic signal, which divide the object under study into areas that are homogeneous by a number of signs, where geophysical well surveys and core studies are also used, which involves the integration of information. A comprehensive interpretation of seismic and borehole data allows predictingat a qualitative level lithofacies variability in local areas, which contributes to a more rational placement of production wells. The main aim of the research is to consider approaches to analyzing a reliable assessment and forecasting the facies structure when searching for promising objects for the most optimal location of exploration wells when planning drilling, taking into account constantly updated and renewed geological information about the formation. The object of the study is the Paleozoic basement deposits of the southeastern part of the West Siberian Plate, which represent rocks of various material composition, including carbonate differences. Methods include statistical analysis of seismic information and geological and geophysical data. The statistical analysis of the spatial change in the facies environment was performed, on the basis of which reliable zones of the presence of certain facies were identified. The proposed strategy for predicting the prospects of oil and gas potential of the Paleozoic sediments on the example of one of the fields in Western Siberia contributed to the identification of promising zones for future planning of well locations

IL-6 Reduces Mitochondrial Replication, and IL-6 Receptors Reduce Chronic Inflammation in NAFLD and Type 2 Diabetes

Interleukin (IL)-6 family cytokines act through a receptor complex with gp130 subunits. IL-6 is a pleiotropic cytokine that regulates inflammation and liver regeneration. Mitochondria are the first to respond to stress and adapt their dynamics in conditions of damage. In this regard, the study aimed to investigate the role of the IL-6 cytokine family (sIL-6Ra, gp130/sIL-6Rb, and IL-11) in the regulation of mitochondrial dynamics in the liver in obese patients and to assess the contribution of these cytokines to the pathogenesis of type 2 diabetes mellitus (T2DM). We studied 134 obese patients with and without T2DM and 41 healthy donors. We found that increasing the concentration of sIL-6Ra and gp130/sIL-6Rb protected against carbohydrate disorders in obese patients and prevented non-alcoholic fatty liver disease (NAFLD) progression in obese patients. An increase in plasma IL-6 levels is associated with decreased, mitochondrial transcription factor A (TFAM) protein production in liver biopsies in obese patients with and without T2DM. Replication, transcription, and division processes in liver biopsy were reduced in patients with T2DM. Inflammatory processes stimulate liver cell apoptosis in obese patients with T2DM. The increase in IL-11 levels is associated with decreased pro-apoptotic Bcl-2-associated X protein (BAX) protein production in obese patients with and without T2DM

IL-6 Reduces Mitochondrial Replication, and IL-6 Receptors Reduce Chronic Inflammation in NAFLD and Type 2 Diabetes

Interleukin (IL)-6 family cytokines act through a receptor complex with gp130 subunits. IL-6 is a pleiotropic cytokine that regulates inflammation and liver regeneration. Mitochondria are the first to respond to stress and adapt their dynamics in conditions of damage. In this regard, the study aimed to investigate the role of the IL-6 cytokine family (sIL-6Ra, gp130/sIL-6Rb, and IL-11) in the regulation of mitochondrial dynamics in the liver in obese patients and to assess the contribution of these cytokines to the pathogenesis of type 2 diabetes mellitus (T2DM). We studied 134 obese patients with and without T2DM and 41 healthy donors. We found that increasing the concentration of sIL-6Ra and gp130/sIL-6Rb protected against carbohydrate disorders in obese patients and prevented non-alcoholic fatty liver disease (NAFLD) progression in obese patients. An increase in plasma IL-6 levels is associated with decreased, mitochondrial transcription factor A (TFAM) protein production in liver biopsies in obese patients with and without T2DM. Replication, transcription, and division processes in liver biopsy were reduced in patients with T2DM. Inflammatory processes stimulate liver cell apoptosis in obese patients with T2DM. The increase in IL-11 levels is associated with decreased pro-apoptotic Bcl-2-associated X protein (BAX) protein production in obese patients with and without T2DM