Investigation of a Recharge Basin to Improve Drought Resiliency and Aquifer Sustainability Rock Valley Rural Water

https://ir.uiowa.edu/igs_wrir/1017/thumbnail.jp

Jefferson groundwater investigation Greene County, Iowa

https://ir.uiowa.edu/igs_tis/1054/thumbnail.jp

Aquifer Sustainability at the Osceola County Rural Water System H-Series Wellfield

https://ir.uiowa.edu/igs_wrir/1019/thumbnail.jp

Aquifer Characterization and Drought Assessment Rock River Alluvial Aquifer

This investigation evaluated groundwater resources of the alluvial aquifer located adjacent to the ock River. Recent drought conditions prompted this study and can have a dramatic affect on groundwater resources. The primary objective of this study was to evaluate the aquifer to aid in future water supply development. Existing geologic information combined with geophysical surveys and drilling were compiled to better understand the extent and thicknesses of coarse grained alluvium. Several hydrogeologic parameters were gathered to estimate well potential in the aquifer. The study can be referenced when considering future development or well field expansion.https://ir.uiowa.edu/igs_wrir/1011/thumbnail.jp

Potential for Geologic Sequestration of CO2 in Iowa

https://ir.uiowa.edu/igs_tis/1056/thumbnail.jp

Mitoxantrone Induces Natural Killer Cell Maturation in Patients with Secondary Progressive Multiple Sclerosis

Mitoxantrone is one of the few drugs approved for the treatment of progressive multiple sclerosis (MS). However, the prolonged use of this potent immunosuppressive agent is limited by the appearance of severe side effects. Apart from its general cytotoxic effect, the mode of action of mitoxantrone on the immune system is poorly understood. Thus, to develop safe therapeutic approaches for patients with progressive MS, it is essential to elucidate how mitoxantrone exerts it benefits. Accordingly, we initiated a prospective single-arm open-label study with 19 secondary progressive MS patients. We investigated long-term effects of mitoxantrone on patient peripheral immune subsets using flow cytometry. While we corroborate that mitoxantrone persistently suppresses B cells in vivo, we show for the first time that treatment led to an enrichment of neutrophils and immunomodulatory CD8low T cells. Moreover, sustained mitoxantrone applications promoted not only persistent NK cell enrichment but also NK cell maturation. Importantly, this mitoxantrone-induced NK cell maturation was seen only in patients that showed a clinical response to treatment. Our data emphasize the complex immunomodulatory role of mitoxantrone, which may account for its benefit in MS. In particular, these results highlight the contribution of NK cells to mitoxantrone efficacy in progressive MS