Cardiac troponin I assessment and late cardiac complications after carotid stenting or endarterectomy

PurposeWhen compared with carotid endarterectomy (CEA), percutaneous carotid angioplasty with stent replacement (CAS) is a less invasive technique in the treatment of carotid stenosis. However, periprocedural hemodynamic instability still remains a challenge. This instability might lead to myocardial damage, which is now measured accurately by using cardiac troponin I (CTnI).MethodsThis study was designed to compare the periprocedural variation of CTnI in 150 consecutive patients scheduled to undergo CEA (n = 75) or CAS (n = 75). The levels of CTnI were measured until the third postoperative day in all patients. Short-term (1 month) and long-term (up to 5 years) postoperative cardiac outcome were assessed by means of chart review, regular follow-ups, and telephone calls.ResultsThere was not any statistically significant difference between the 2 groups regarding the demographic characteristics and preprocedural medical status. The incidence of increase of CTnI (>0.5 ng/mL) was significantly higher in the CEA group (13%) compared with that in the CAS group (1%; P = .001). During the acute postprocedural period, the CAS group was significantly more prone to hypotension, requiring vasopressor therapy, whereas the CEA group had more hypertension, necessitating hypotensive medications (P < .001). At 5 years, the overall incidence of major cardiac complications (nonfatal myocardial infarction and death related to cardiac origin) was significantly more frequent in the CEA group (20% vs 5%, P < .01).ConclusionThe results of our study suggest that CAS yielded less myocardial damage in the short and long term when compared with CEA. Larger randomized multicenter trials with long-term outcomes are necessary to confirm our findings

Rapid Detection of Polychlorinated Biphenyls at Trace Levels in Real Environmental Samples by Surface-Enhanced Raman Scattering

Detection of trace levels of persistent pollutants in the environment is difficult but significant. Organic pollutant homologues, due to their similar physical and chemical properties, are even more difficult to distinguish, especially in trace amounts. We report here a simple method to detect polychlorinated biphenyls (PCBs) in soil and distilled spirit samples by the surface-enhanced Raman scattering technique using Ag nanorod arrays as substrates. By this method, polychlorinated biphenyls can be detected to a concentration of 5 μg/g in dry soil samples within 1 minute. Furthermore, based on simulation and understanding of the Raman characteristics of PCBs, we recognized homologues of tetrachlorobiphenyl by using the surface-enhance Raman scattering method even in trace amounts in acetone solutions, and their characteristic Raman peaks still can be distinguished at a concentration of 10−6 mol/L. This study provides a fast, simple and sensitive method for the detection and recognition of organic pollutants such as polychlorinated biphenyls

Bottom-up microwave-assisted seed-mediated synthesis of gold nanoparticles onto nanocellulose to boost stability and high performance for SERS applications

The development of accurate, reliable, inexpensive and fully recyclable analytical platforms is of utmost relevance to several fields from medical diagnosis to environmental screening. Surface-enhanced Raman spectroscopy (SERS) is a compelling detection method with high specificity and sensitivity. In this work, a microwave-assisted synthesis method was used for fast and uniform in situ growth of gold nanoparticles (AuNPs) onto nanocellulose (NC) membranes, through a seedmediated process. The as-prepared membranes were fully optimized and its application as SERS platforms was demonstrated. A direct comparison with other cellulose-based substrates showed the superior characteristics of NC such as high mechanical strength, high surface area and lower porous content. An Enhancement Factor (EF) up to 106 was obtained using rhodamine 6G (R6G) 10-6 M as probe molecule and a remarkable shelf life of at least 7 months was achieved, with no special storage required. Preliminary results on the detection of label-free spike protein present in SARSCoV-2 virus are shown, through direct measurements on the optimized SERS membrane. We believe that this work evidences the effectiveness of in situ seed-mediated microwave-assisted synthesis as a fabrication method, the high stability of AuNPs and the superior characteristics of NC substrates to be used as SERS platforms.This work is funded by National Funds through FCT I.P., under the scope of the project UIDB/50025/2020-2023. The authors acknowledge the ERC AdG project DIGISMART ref. 787410 and EC project SYNERGY H2020-WIDESPREAD-2020-5, CSA, proposal n° 952169. Also, the authors thank funding co-financed by the Operational Programme for Competitiveness and Internationalisation (COMPETE 2020) and Lisbon Regional Operational Programme (Lisboa 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) under the projects ECO2COVID ref. 68174 and TecniCOV ref. 69745. A. C. Marques acknowledges funding from FCT I.P., through the PhD Grant SFRH/BD/115173/2016. The authors acknowledge Professor Pedro Costa from KAUST for the TEM imaging.info:eu-repo/semantics/publishedVersio

Quelle démarche globale de suivi pour les réserves naturelles de Haute-Savoie ? Réflexions autour de la construction d'un observatoire

National audienc

Quelle démarche globale de suivi pour les réserves naturelles de Haute-Savoie ? Réflexions autour de la construction d'un observatoire

National audienc

Qualité physico-chimique et bactériologique des sources du domaine de Platé (Haute-savoie)

On the high alpine karst of Platé (Haute-Savoie ), eight springs on four catchments have been submitted to physico-chemical and bacteriological analysis. The skiing \ station of Flaine is situated on one of the catchment, the others are not very frequented (mountain pasture, cattle). These springs have a good physico-chemical quality but only one of them is drinkable. The others are contamined by pathological germs contained in human and animal excrements. This phenomenon is amplified by the ground and earth leaching due to rain storms. On the other hand, the skiing station of Flaine could be responsable of a chronic pollution of the Salles spring. All traditional fréquentation of this area makes the waters \ inusable and undrinkable, and all additional development on the karst could only aggravate this situation and compromise the use of water.Sur le karst haut alpin du domaine de Platé (Haute-Savoie, France), huit sources réparties sur quatre bassins-versants ont fait l'objet d'analyses physico-chimiques et bactériologiques. La station de Flaine occupe un bassin-versant, les autres sont faiblement fréquentés (chalets d'alpage, troupeaux). Ces sources sont de bonne qualité physico-chimique, mais une seule est potable. Les autres sont contaminées par des germes pathogènes contenus dans des excréments i humains ou animaux. Ce phénomène s'amplifie lors du lessivage des sols par les crues d'orage. En outre la station de Flaine serait responsable d'une pollution chronique de la source de Salles. Toute fréquentation traditionnelle de ce massif rend les eaux impropres à la consomma¬ tion de sorte que tout aménagement sur le karst ne pourrait qu'aggraver cette situation et compromettre l'utilisation de l'eau.Buisson -Vodinh Juliette. Qualité physico-chimique et bactériologique des sources du domaine de Platé (Haute-savoie). In: Karstologia : revue de karstologie et de spéléologie physique, n°16, 2e semestre 1990. pp. 29-38

Quels apports et limites à l'exploration du phénomène fréquentation touristique pour le développement d'une gestion concertée ? Le cas des Réserves Naturelles de Haute-Savoie et du programme "sentiers en espaces protégés

Montagnes Méditerranéennes, n° 18National audienceAt the end of an interdisciplinary research program aiming to develop tools and scientific knowledge for a consistent management of protected areas, the authors underline the importance of questionings linked to concerted management in protected areas. The authors begin with an explanation of the interest of a set of problems common to the stakeholders (protected areas managers, trails users, scientists, ...) and then expose their position on the notion of consultation. The last part of this contribution consists in a review of their research program in order to appreciate the potential contribution of scientific studies for the development of concerted management in the natural reserves of Arve-Giffre sector (Haute-Savoie, France).A l'issue d'un programme de recherche interdisciplinaire visant le développement d'outils et acquis scientifiques pour une stratégie cohérente de gestion des espaces protégés, les auteurs mettent en évidence l'importance actuelle des questionnements liés à la gestion concertée en espace protégé. Par une explicitation de l'intérêt de la construction d'une problématique commune aux différents protagonistes (gestionnaires, usagers, scientifiques) et une interpellation de la notion de concertation, un retour sur expérience est réalisé, afin de viser l'apport potentiel de travaux scientifiques dans l'instauration d'une dynamique de gestion concertée au sein des Réserves Naturelles du secteur Arve-Giffre (Haute-Savoie, France)

Quels apports et limites à l'exploration du phénomène fréquentation touristique pour le développement d'une gestion concertée ? Le cas des Réserves Naturelles de Haute-Savoie et du programme "sentiers en espaces protégés

Montagnes Méditerranéennes, n° 18National audienceAt the end of an interdisciplinary research program aiming to develop tools and scientific knowledge for a consistent management of protected areas, the authors underline the importance of questionings linked to concerted management in protected areas. The authors begin with an explanation of the interest of a set of problems common to the stakeholders (protected areas managers, trails users, scientists, ...) and then expose their position on the notion of consultation. The last part of this contribution consists in a review of their research program in order to appreciate the potential contribution of scientific studies for the development of concerted management in the natural reserves of Arve-Giffre sector (Haute-Savoie, France).A l'issue d'un programme de recherche interdisciplinaire visant le développement d'outils et acquis scientifiques pour une stratégie cohérente de gestion des espaces protégés, les auteurs mettent en évidence l'importance actuelle des questionnements liés à la gestion concertée en espace protégé. Par une explicitation de l'intérêt de la construction d'une problématique commune aux différents protagonistes (gestionnaires, usagers, scientifiques) et une interpellation de la notion de concertation, un retour sur expérience est réalisé, afin de viser l'apport potentiel de travaux scientifiques dans l'instauration d'une dynamique de gestion concertée au sein des Réserves Naturelles du secteur Arve-Giffre (Haute-Savoie, France)

Contrôle de la traînée dans la zone de paroi d'un canal plan turbulent à l'aide de réseaux de neurones

PARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF