Hrvatsko biomedicinsko nazivlje – izazov za jezikoslovce

Institut za hrvatski jezik i jezikoslovlje započeo je 2008. projekt "Hrvatsko strukovno nazivlje" koji financira Hrvatska zaklada za znanost. Unutar toga koordinacijskog projekta pokrenuto je više podprojekata. Hrvatsko stomatološko nazivlje (2009. – 2010.) i Hrvatsko anatomsko i fiziološko nazivlje (2012. - ) projekti su stomatološkog fakulteta sveučilišta u Zagrebu koji imaju dvostruku svrhu: doprinijeti izgradnji hrvatskoga biomedicinskog nazivlja i popularizirati njegovu uporabu među liječnicima, stomatolozima, znanstvenicima te studentima medicine i stomatologije. Rezultati projekta pokazali su da dobro pripremljeni, multidisciplinarni i ciljani projekti mogu unaprijediti strukovni jezik, spriječiti pretjeranu uporabu tuđica i neodgovarajućih prijevoda u hrvatskom jeziku, a profesionalno prevođenje učiniti znatno jednostavnijim i pouzdanijim. sve to podiže kompetitivnost hrvatskih znanstvenika na međunarodnoj razini i pridonosi mogućnosti uključivanja hrvatskih znanstvenika, liječnika i stomatologa u europske projekte

Hrvatsko biomedicinsko nazivlje – izazov za jezikoslovce

Institut za hrvatski jezik i jezikoslovlje započeo je 2008. projekt "Hrvatsko strukovno nazivlje" koji financira Hrvatska zaklada za znanost. Unutar toga koordinacijskog projekta pokrenuto je više podprojekata. Hrvatsko stomatološko nazivlje (2009. – 2010.) i Hrvatsko anatomsko i fiziološko nazivlje (2012. - ) projekti su stomatološkog fakulteta sveučilišta u Zagrebu koji imaju dvostruku svrhu: doprinijeti izgradnji hrvatskoga biomedicinskog nazivlja i popularizirati njegovu uporabu među liječnicima, stomatolozima, znanstvenicima te studentima medicine i stomatologije. Rezultati projekta pokazali su da dobro pripremljeni, multidisciplinarni i ciljani projekti mogu unaprijediti strukovni jezik, spriječiti pretjeranu uporabu tuđica i neodgovarajućih prijevoda u hrvatskom jeziku, a profesionalno prevođenje učiniti znatno jednostavnijim i pouzdanijim. sve to podiže kompetitivnost hrvatskih znanstvenika na međunarodnoj razini i pridonosi mogućnosti uključivanja hrvatskih znanstvenika, liječnika i stomatologa u europske projekte

Correlation of Chronological Age with Tooth Wear in Archaeological Populations

Knowing that attrition and abrasion are most common wear processes of dental hard tissue, which occurs along with aging, the aim of this paper is to determine the correlation between dental age and loss of dental hard tissue on archeological bone residues. For the purpose of this research, the collection of skeletal remains of the Croatian Academy of Sciences and Arts (HAZU) was used. The study includes 392 samples of the remains of both upper and lower jaws from 7 Croatian archaeological sites, whereas 4 of them from continental and 3 of them from coastal Croatia. The remains of bones belong to two different archeological periods, late antiquity and early Middle Ages. Visa Metrix computer system was used on digital photography of occlusal tooth surfaces to measure total exposed area of dental hard tissue and surface of dental hard tissues damaged by attrition and abrasion. Data provided were defined in sq. cm, and as such were inserted in excel table and processed statistically. In the statistical analysis of data, Shapiro-Wilk test, Mann-Whitney U test and Kruskal-Wallis test were used. There is a statistically significant correlation between the total teeth number and estimated chronological age (χ² = 46.3, ƞ² = 0.23, p <0.001). Total number of teeth negatively correlates with chronological age (r = –0.41, p <0.001). The total surface area of the teeth available decreases with the estimated chronological age (r = –0.39, p <0.001), while the proportion (%) of the total damaged area of the teeth in relation to the total available area increases with the estimated chronological age (r = 0.622, P <0.001). The proportion of damaged surface in overall teeth surface increases with the estimated chronological age (r = 0.686; p <0.001) both in males and females (r = 0.534; p <0.001). The lifelong loss of hard tooth tissue positively correlates with chronological age in both sexes despite of historical period. The loss of hard tooth tissue due to attrition and abrasive changes, and with usage of Vista Metrix Inc. computer system can now be used to determine age in forensic dentistry as well as forensic anthropology and archeology

Opsežna duboka venska tromboza u mladog bolesnika kao prva manifestacija rijetke venske anomalije – dvostruke donje šuplje vene: prikaz slučaja

Although venous thromboembolism (VTE) including deep venous thrombosis (DVT) and pulmonary embolism is a major health problem in the world, it is an infrequent disease among young people. It is always mandatory to look at the underlying conditions for VTE, and in young patients, inherited prothrombotic factors should also be evaluated, especially in case of unprovoked VTE. Anomalies of inferior vena cava (IVC) are very rare in the general population. In this case report we describe rare occurrence of extensive DVT in a young male patient with rare anomaly of IVC – duplication of IVC – as a predisposition factor for DVT. Physicians need to be reminded of the IVC anomalies that should be considered in young patients with idiopathic DVT of lower extremity, which may require extended anticoagulant treatment.Iako su venske tromboembolije (VTE) koje uključuju duboku vensku trombozu (DVT) i plućnu emboliju značajan zdravstveni problem u svijetu, one su rijetke bolesti u mladih osoba. Uvijek je potrebno ispitati uzroke koji su doveli do nastanka VTE, a u mladih bolesnika potrebno je također evaluirati i nasljedne protrombotske čimbenike, osobito kod nastanka neprovocirane VTE. Anomalije donje šuplje vene su vrlo rijetke u općoj populaciji. U ovom prikazu slučaja opisujemo rijedak slučaj mladog bolesnika s opsežnom DVT i rijetkom anomalijom donje šuplje vene – dvostrukom donjom šupljom venom – kao čimbenikom rizika za nastanak DVT. Potrebno je podsjetiti liječnike na postojanje anomalija donje šuplje vene koje treba razmotriti u mladih bolesnika s idiopatskom DVT donjih ekstremiteta, što može zahtijevati dugotrajno antikoagulantno liječenje

Influence of blood count, cardiovascular risks, inherited thrombophilia, and JAK2 V617F burden allele on type of thrombosis in patients with Philadelphia chromosome negative myeloproliferative neoplasms

Introduction: Thrombosis is the most common complication in Philadelphia chromosome negative (Ph-) myeloproliferative neoplasms patients. ----- Patients and methods: In a cohort of 258 Ph- myeloproliferative neoplasm patients, the difference between patients with and without thrombosis was analyzed according to genetic thrombophilia factors, JAK2 V617F status and burden allele, blood count, cardiovascular risk factors and age. Patients were also divided in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) subgroups as well as by the type of thrombosis. ----- Results: Analysis of cardiovascular risk factors regarding arterial thrombosis showed that PV patients with thrombosis had higher incidence of diabetes (P = .030), ET patients more often had hypertension (P = .003) and hyperlipidemia (P = .005), while PMF patients had hyperlipidemia (P = .046) and at least one cardiovascular risk factor (P = .044). Moreover, leukocytes > 18 × 109/L and V617F burden allele > 25.7% were statistically significantly different in PV patients (P = .019 and borderline significant at P = .055, respectively), while in ET patients leukocytes > 9.2 × 109/L (P 55 years were statistically significantly different (P = .002). PMF patients with V617F burden allele ≤ 34.8% were more prone to thrombosis (P = .032). When comparing patients with and without venous thrombosis, cutoff value of V617F burden allele > 90.4% was significant for PV patients with thrombosis (P = .036), as was > 56.7% for PMF patients with thrombosis (P = .046). Platelets ≤ 536 × 109/L and age at diagnosis > 54 years showed statistically significant difference for ET patients with thrombosis (P = .015 and P = .041, respectively). ----- Conclusion: On the basis of our results, a new scoring system for thrombosis risk in PV could be made, while PMF prognostic model may be expanded for better recognition of potential thrombotic risk factors

RAZLIKA U PERINATALNOM ISHODU JEDNOPLODNIH I VIŠEPLODNIH TRUDNOĆA NAKON MEDICINSKI POTPOMOGNUTE OPLODNJE

Cilj istraživanja: Odrediti perinatalni ishod jednoplodnih i višeplodnih trudnoća nakon medicinski potpomognute oplodnje (MPO). Materijal i metode: Retrospektivno je pregledana medicinska dokumentacija Klinike za ženske bolesti i porode te su izdvojene žene koje su rodile živorođenu djecu iz jednoplodnih i višeplodnih trudnoća nakon MPO u dvogodišnjem razdoblju, od 1. siječnja 2011. do 31. prosinca 2012. godine. U istraživanje je uključeno 164 rodilje koje su zanijele nakon MPO od kojih je 99 imalo jednoplodnu, a 65 višeplodnu trudnoću. Promatrane varijable bile su dob, paritet, indeks tjelesne mase (kg/m2), navršeni tjedan poroda (prijevremeni ≤366/7 i terminski ≥37), način dovršetka porođaja (vaginalno i carski rez), porođajna masa novorođenčeta (grami), trofičnost novorođenčeta (hipotrofično, eutrofično, hipertrofično) i Apgar zbroj novorođenčeta (≤7, 8-10). Rezultati: Među ispitivanim skupinama nije bilo značajne razlike u paritetu (P=0,396), broju pobačaja (P=0,748), indeksu tjelesne mase na početku (P=0,613) i na kraju trudnoće (P=0,932) te učestalosti preeklampsije (P=0,236), dok je razlika postojala u prosječnoj životnoj dobi majke prilikom začeća (P=0,032). Utvrđena je statistički značajna razlika u učestalosti prijevremenog porođaja (P<0,001) i načinu dovršetka porođaja (P<0,001). Žene s blizanačkom trudnoćom u usporedbi sa ženama s jednoplodnom trudnoćom nakon MPO, imaju veću učestalost rađanja novorođenčadi niske porođajne mase (P<0,001) i smanjenog ≤7 Apgar zbroja (P<0,001). Veća učestalost rađanja hipertrofične novorođenčadi nađena je u jednoplodnim trudnoćama nakon MPO (P=0,005). Zaključci: Nakon postupaka potpomognute oplodnje, višeplodne trudnoće imaju lošiji perinatalni ishod od jednoplodnih trudnoća.Objective: To determine perinatal outcome of singleton and multiple pregnancies conceived after assisted reproductive technologies (ART). Materials and Methods: Medical documentation of Department of Gynecology and Obstetrics has been retrospectively analyzed and women who gave birth to singleton and multiple newborns after ART in a two-year period (from January 1st , 2011 to December 31st, 2012) have been selected. 164 pregnant women who conceived after ART (99 singleton and 65 multiple pregnancies) have been included into the research. The observed variables were maternal age (years), parity, body mass index (kg/m2), week of delivery (≤ 366/7, ≥ 37), mode of delivery (vaginal and cesarean section), birth weight (grams), newborn’s trophicity (small for gestational age, appropriate for gestational age, large for gestational age) and Apgar score (≤7, 8-10). Results: There was no significant difference in parity (P=0,396), number of abortions (P=0,748), body mass index at the beginning (P=0,613) and the end of a pregnancy (P=0,932) and the frequency of preeclampsia (P=0,236) among the analyzed groups, while the clear difference was seen in the average maternal age at conception (P=0,032). Statistically significant difference in the frequency of preterm birth (P <0.001) and the mode of delivery (P <0.001) has been proven. Women with twin pregnancies in comparison to women with singleton pregnancies, after ART, have higher incidence of giving birth to infants with low birth weight (P<0,001) and decreased Apgar score ≤ 7 (P <0.001). Higher incidence of giving birth to large for gestational age newborns was found in singleton pregnancies after ART (P = 0.005). Conclusions: After ART, multiple pregnancies have poorer perinatal outcome than singleton pregnancies

RAZLIKA U PERINATALNOM ISHODU JEDNOPLODNIH I VIŠEPLODNIH TRUDNOĆA NAKON MEDICINSKI POTPOMOGNUTE OPLODNJE

Cilj istraživanja: Odrediti perinatalni ishod jednoplodnih i višeplodnih trudnoća nakon medicinski potpomognute oplodnje (MPO). Materijal i metode: Retrospektivno je pregledana medicinska dokumentacija Klinike za ženske bolesti i porode te su izdvojene žene koje su rodile živorođenu djecu iz jednoplodnih i višeplodnih trudnoća nakon MPO u dvogodišnjem razdoblju, od 1. siječnja 2011. do 31. prosinca 2012. godine. U istraživanje je uključeno 164 rodilje koje su zanijele nakon MPO od kojih je 99 imalo jednoplodnu, a 65 višeplodnu trudnoću. Promatrane varijable bile su dob, paritet, indeks tjelesne mase (kg/m2), navršeni tjedan poroda (prijevremeni ≤366/7 i terminski ≥37), način dovršetka porođaja (vaginalno i carski rez), porođajna masa novorođenčeta (grami), trofičnost novorođenčeta (hipotrofično, eutrofično, hipertrofično) i Apgar zbroj novorođenčeta (≤7, 8-10). Rezultati: Među ispitivanim skupinama nije bilo značajne razlike u paritetu (P=0,396), broju pobačaja (P=0,748), indeksu tjelesne mase na početku (P=0,613) i na kraju trudnoće (P=0,932) te učestalosti preeklampsije (P=0,236), dok je razlika postojala u prosječnoj životnoj dobi majke prilikom začeća (P=0,032). Utvrđena je statistički značajna razlika u učestalosti prijevremenog porođaja (P<0,001) i načinu dovršetka porođaja (P<0,001). Žene s blizanačkom trudnoćom u usporedbi sa ženama s jednoplodnom trudnoćom nakon MPO, imaju veću učestalost rađanja novorođenčadi niske porođajne mase (P<0,001) i smanjenog ≤7 Apgar zbroja (P<0,001). Veća učestalost rađanja hipertrofične novorođenčadi nađena je u jednoplodnim trudnoćama nakon MPO (P=0,005). Zaključci: Nakon postupaka potpomognute oplodnje, višeplodne trudnoće imaju lošiji perinatalni ishod od jednoplodnih trudnoća.Objective: To determine perinatal outcome of singleton and multiple pregnancies conceived after assisted reproductive technologies (ART). Materials and Methods: Medical documentation of Department of Gynecology and Obstetrics has been retrospectively analyzed and women who gave birth to singleton and multiple newborns after ART in a two-year period (from January 1st , 2011 to December 31st, 2012) have been selected. 164 pregnant women who conceived after ART (99 singleton and 65 multiple pregnancies) have been included into the research. The observed variables were maternal age (years), parity, body mass index (kg/m2), week of delivery (≤ 366/7, ≥ 37), mode of delivery (vaginal and cesarean section), birth weight (grams), newborn’s trophicity (small for gestational age, appropriate for gestational age, large for gestational age) and Apgar score (≤7, 8-10). Results: There was no significant difference in parity (P=0,396), number of abortions (P=0,748), body mass index at the beginning (P=0,613) and the end of a pregnancy (P=0,932) and the frequency of preeclampsia (P=0,236) among the analyzed groups, while the clear difference was seen in the average maternal age at conception (P=0,032). Statistically significant difference in the frequency of preterm birth (P <0.001) and the mode of delivery (P <0.001) has been proven. Women with twin pregnancies in comparison to women with singleton pregnancies, after ART, have higher incidence of giving birth to infants with low birth weight (P<0,001) and decreased Apgar score ≤ 7 (P <0.001). Higher incidence of giving birth to large for gestational age newborns was found in singleton pregnancies after ART (P = 0.005). Conclusions: After ART, multiple pregnancies have poorer perinatal outcome than singleton pregnancies