797 research outputs found
An observationally-driven kinetic approach to coronal heating
Coronal heating through the explosive release of magnetic energy remains an
open problem in solar physics. Recent hydrodynamical models attempt an
investigation by placing swarms of 'nanoflares' at random sites and times in
modeled one-dimensional coronal loops. We investigate the problem in three
dimensions, using extrapolated coronal magnetic fields of observed solar active
regions. We apply a nonlinear force-free field extrapolation above an observed
photospheric magnetogram of NOAA active region (AR) 11158. We then determine
the locations, energy contents, and volumes of 'unstable' areas, namely areas
prone to releasing magnetic energy due to locally accumulated electric current
density. Statistical distributions of these volumes and their fractal dimension
are inferred, investigating also their dependence on spatial resolution.
Further adopting a simple resistivity model, we infer the properties of the
fractally distributed electric fields in these volumes. Next, we monitor the
evolution of 10^5 particles (electrons and ions) obeying an initial Maxwellian
distribution with a temperature of 10 eV, by following their trajectories and
energization when subjected to the resulting electric fields. For computational
convenience, the length element of the magnetic-field extrapolation is 1
arcsec, much coarser than the particles collisional mean free path in the low
corona. The presence of collisions traps the bulk of the plasma around the
unstable volumes, or current sheets (UCS), with only a tail of the distribution
gaining substantial energy. Assuming that the distance between UCS is similar
to the collisional mean free path we find that the low active-region corona is
heated to 100-200 eV, corresponding to temperatures exceeding 2 MK, within tens
of seconds for electrons and thousands of seconds for ions. Fractally
distributed, nanoflare-triggening fragmented UCS ...Comment: accepted by A&
Particle Acceleration in Multiple Dissipation Regions
The sharp magnetic discontinuities which naturally appear in solar magnetic
flux tubes driven by turbulent photospheric motions are associated with intense
currents. \citet{Par83} proposed that these currents can become unstable to a
variety of microscopic processes, with the net result of dramatically enhanced
resistivity and heating (nanoflares). The electric fields associated with such
``hot spots'' are also expected to enhance particle acceleration. We test this
hypothesis by exact relativistic orbit simulations in strong random phase
magnetohydrodynamic (MHD) turbulence which is forming localized super-Dreicer
Ohm electric fields ( = ) occurring in 2..15 % of
the volume. It is found that these fields indeed yield a large amplification of
acceleration of electrons and ions, and can effectively overcome the injection
problem. We suggest in this article that nanoflare heating will be associated
with sporadic particle acceleration.Comment: 12 pages, 5 figures, to appear in ApJ
Serum Amyloid A induces toll-like receptor 2-dependent inflammatory cytokine expression and atrophy in C2C12 skeletal muscle myotubes
Background Skeletal muscle wasting is an important comorbidity of Chronic Obstructive Pulmonary Disease (COPD) and is strongly correlated with morbidity and mortality. Patients who experience frequent acute exacerbations of COPD (AECOPD) have more severe muscle wasting and reduced recovery of muscle mass and function after each exacerbation. Serum levels of the pro-inflammatory acute phase protein Serum Amyloid A (SAA) can rise more than 1000-fold in AECOPD and are predictively correlated with exacerbation severity. The direct effects of SAA on skeletal muscle are poorly understood. Here we have examined SAA effects on pro-inflammatory cachectic cytokine expression (IL-6 and TNFα) and atrophy in C2C12 myotubes. Results SAA increased IL-6 (31-fold) and TNFα (6.5-fold) mRNA levels compared to control untreated cells after 3h of SAA treatment, and increased secreted IL-6 protein at 24h. OxPAPC, a dual TLR2 and TLR4 inhibitor, reduced the response to SAA by approximately 84% compared to SAA alone, and the TLR2 neutralising antibody T2.5 abolished SAA-induced expression of IL-6, indicating that SAA signalling in C2C12 myotubes is primarily via TLR2. SAA also reduced myotube width by 10-13% and induced a 2.5-fold increase in the expression of the muscle atrophy gene Atrogin-1, suggesting direct effects of SAA on muscle wasting. Blocking of TLR2 inhibited the SAA-induced decrease in myotube width and Atrogin-1 gene expression, indicating that SAA induces atrophy through TLR2. Conclusions These data demonstrate that SAA stimulates a robust pro-inflammatory response in skeletal muscle myotubes via the TLR2-dependent release of IL-6 and TNFα. Furthermore, the observed atrophy effects indicate that SAA could also be directly contributing to the wasting and poor recovery of muscle mass. Therapeutic strategies targeting this SAA-TLR2 axis may therefore ameliorate muscle wasting in AECOPD and a range of other inflammatory conditions associated with loss of m
Are Coronae of Magnetically Active Stars Heated by Flares? III. Analytical Distribution of Superimposed Flares
(abridged) We study the hypothesis that observed X-ray/extreme ultraviolet
emission from coronae of magnetically active stars is entirely (or to a large
part) due to the superposition of flares, using an analytic approach to
determine the amplitude distribution of flares in light curves. The
flare-heating hypothesis is motivated by time series that show continuous
variability suggesting the presence of a large number of superimposed flares
with similar rise and decay time scales. We rigorously relate the amplitude
distribution of stellar flares to the observed histograms of binned counts and
photon waiting times, under the assumption that the flares occur at random and
have similar shapes. Applying these results to EUVE/DS observations of the
flaring star AD Leo, we find that the flare amplitude distribution can be
represented by a truncated power law with a power law index of 2.3 +/- 0.1. Our
analytical results agree with existing Monte Carlo results of Kashyap et al.
(2002) and Guedel et al. (2003). The method is applicable to a wide range of
further stochastically bursting astrophysical sources such as cataclysmic
variables, Gamma Ray Burst substructures, X-ray binaries, and spatially
resolved observations of solar flares.Comment: accepted for publication in Ap
Random walk through fractal environments
We analyze random walk through fractal environments, embedded in
3-dimensional, permeable space. Particles travel freely and are scattered off
into random directions when they hit the fractal. The statistical distribution
of the flight increments (i.e. of the displacements between two consecutive
hittings) is analytically derived from a common, practical definition of
fractal dimension, and it turns out to approximate quite well a power-law in
the case where the dimension D of the fractal is less than 2, there is though
always a finite rate of unaffected escape. Random walks through fractal sets
with D less or equal 2 can thus be considered as defective Levy walks. The
distribution of jump increments for D > 2 is decaying exponentially. The
diffusive behavior of the random walk is analyzed in the frame of continuous
time random walk, which we generalize to include the case of defective
distributions of walk-increments. It is shown that the particles undergo
anomalous, enhanced diffusion for D_F < 2, the diffusion is dominated by the
finite escape rate. Diffusion for D_F > 2 is normal for large times, enhanced
though for small and intermediate times. In particular, it follows that
fractals generated by a particular class of self-organized criticality (SOC)
models give rise to enhanced diffusion. The analytical results are illustrated
by Monte-Carlo simulations.Comment: 22 pages, 16 figures; in press at Phys. Rev. E, 200
Presence of antiphospholipid antibodies is associated with increased implantation failure following in vitro fertilization technique and embryo transfer: A systematic review and meta-analysis
PURPOSE: A systematic review and meta-analysis was conducted comparing the presence of anti-phospholipid (anti-PL) antibodies between women of reproductive age, without diagnosis of antiphospholipid syndrome, who experienced at least two implantation failures following in vitro fertilization and embryo transfer (IVF-ET), and either women who had a successful implantation after IVF-ET or women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET. METHODS: Systematic search of the literature and meta-analysis of the relevant studies studying presence of antiphospholipid antibodies in women experiencing at least two implantation failures in IVF-ET as compared to either women who had a successful implantation after IVF-ET or/and women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET. Six hundred ninety-four published reports were retrieved; 17 of them fulfilled the inclusion criteria set. RESULTS: Presence of either any type of anti-phospholipid or anticardiolipin antibodies or lupus-anticoagulant in women experiencing at least two implantation failures in IVF-ET was associated with increased implantation failure compared to women who had a successful implantation after IVF-ET (relative risk, RR: 3.06, 5.06 and 5.81, respectively). Presence of either anticardiolipin or lupus-anticoagulant or anti-beta(2) glycoprotein-I or anti-phosphatidylserine antibodies in women experiencing at least two implantation failures in IVF-EΤ was associated with increased implantation failure compared to unselected healthy fertile women with no history of IVF-ET (RR:13.92, 6.37, 15.04 and 164.58, respectively). CONCLUSION: The prevalence of antiphospholipid antibodies, particularly that of anti-beta(2) glycoprotein-I and anti-phosphatidylserine antibodies, in women experiencing at least two implantation failures in IVF-ET without diagnosis of antiphospholipid syndrome is significantly greater than either in women who had a successful implantation after IVF-ET or women with at least one successful spontaneous pregnancy or unselected healthy fertile women with no history of IVF-ET. TRIAL REGISTRATION NUMBER: PROSPERO ID: CRD4201808145
Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress
Influenza A virus infection is an ongoing clinical problem and thus, there is an urgent need to understand the mechanisms that regulate the lung inflammation in order to unravel novel generic pharmacological strategies. Evidence indicates that the Nox2-containing NADPH oxidase enzyme promotes influenza A virus-induced lung oxidative stress, inflammation and dysfunction via ROS generation. In addition, lung epithelial and endothelial cells express the Nox1 isoform of NADPH oxidase, placing this enzyme at key sites to regulate influenza A virus-induced lung inflammation. The aim of this study was to investigate whether Nox1 oxidase regulates the inflammatory response and the oxidative stress to influenza infection in vivo in mice. Male WT and Nox1-deficient (Nox1−/y) mice were infected with the moderately pathogenic HkX-31 (H3N2, 1×104 PFU) influenza A virus for analysis of bodyweight, airways inflammation, oxidative stress, viral titre, lung histopathology, and cytokine/chemokine expression at 3 and 7 days post infection. HkX-31 virus infection of Nox1−/y mice resulted in significantly greater: loss of bodyweight (Day 3); BALF neutrophilia, peri-bronchial, peri-vascular and alveolar inflammation; Nox2-dependent inflammatory cell ROS production and peri-bronchial, epithelial and endothelial oxidative stress. The expression of pro-inflammatory cytokines including CCL2, CCL3, CXCL2, IL-1β, IL-6, GM-CSF and TNF-α was higher in Nox1−/y lungs compared to WT mice at Day 3, however, the expression of CCL2, CCL3, CXCL2, IFN-γ and the anti-inflammatory cytokine IL-10 were lower in lungs of Nox1−/y mice vs. WT mice at Day 7. Lung viral titre, and airways infiltration of active CD8+ and CD4+ T lymphocytes, and of Tregs were similar between WT and Nox1−/y mice. In conclusion, Nox1 oxidase suppresses influenza A virus induced lung inflammation and oxidative stress in mice particularly at the early phases of the infection. Nox1 and Nox2 oxidases appear to have opposing roles in the regulation of inflammation caused by influenza A viruses
The Effect of Coherent Structures on Stochastic Acceleration in MHD Turbulence
We investigate the influence of coherent structures on particle acceleration
in the strongly turbulent solar corona. By randomizing the Fourier phases of a
pseudo-spectral simulation of isotropic MHD turbulence (Re ), and
tracing collisionless test protons in both the exact-MHD and phase-randomized
fields, it is found that the phase correlations enhance the acceleration
efficiency during the first adiabatic stage of the acceleration process. The
underlying physical mechanism is identified as the dynamical MHD alignment of
the magnetic field with the electric current, which favours parallel
(resistive) electric fields responsible for initial injection. Conversely, the
alignment of the magnetic field with the bulk velocity weakens the acceleration
by convective electric fields - \bfu \times \bfb at a non-adiabatic stage of
the acceleration process. We point out that non-physical parallel electric
fields in random-phase turbulence proxies lead to artificial acceleration, and
that the dynamical MHD alignment can be taken into account on the level of the
joint two-point function of the magnetic and electric fields, and is therefore
amenable to Fokker-Planck descriptions of stochastic acceleration.Comment: accepted for publication in Ap
The Emission of Electromagnetic Radiation from Charges Accelerated by Gravitational Waves and its Astrophysical Implications
We provide calculations and theoretical arguments supporting the emission of
electromagnetic radiation from charged particles accelerated by gravitational
waves (GWs). These waves have significant indirect evidence to support their
existence, yet they interact weakly with ordinary matter. We show that the
induced oscillations of charged particles interacting with a GW, which lead to
the emission of electromagnetic radiation, will also result in wave
attenuation. These ideas are supported by a small body of literature, as well
as additional arguments for particle acceleration based on GW memory effects.
We derive order of magnitude power calculations for various initial charge
distributions accelerated by GWs. The resulting power emission is extremely
small for all but very strong GWs interacting with large quantities of charge.
If the results here are confirmed and supplemented, significant consequences
such as attenuation of early universe GWs could result. Additionally, this
effect could extend GW detection techniques into the electromagnetic regime.
These explorations are worthy of study to determine the presence of such
radiation, as it is extremely important to refine our theoretical framework in
an era of active GW astrophysics.Comment: Appears in Gravitational Wave Astrophysics, Editor C.F. Sopuerta,
Astrophysics and Space Science Proceedings, Volume 40. ISBN
978-3-319-10487-4. Springer International Publishing Switzerland, 2015, p.
30
Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette smoke-induced lung inflammation in mice
Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung immunity and inflammation. The aim of this study was to investigate how IL-17A regulates CS-induced lung inflammation in vivo . IL-17A KO mice and neutralisation of IL-17A in WT mice reduced macrophage and neutrophil recruitment and CCL2, CCL3 and MMP-12 mRNA expression in response to acute CS exposure. IL-17A expression was increased in NOD SCID mice with non-functional B and T cells over a 4 week CS exposure period, where macrophages accumulated to the same extent as WT mice. Gene expression analysis by QPCR of isolated immune cell subsets detected increased levels of IL-17A transcript in macrophages, neutrophils and NK/NKT cells in the lungs of CS-exposed mice. In order to further explore the relative contribution of innate immune cellular sources, intracellular IL-17A staining was performed. Here, we demonstrate that CS exposure primes NK, NKT and γδ T cells to produce more IL-17A protein and CS alone increased the frequency of IL17+ γδ T cells in the lung, whereas IL-17A protein was not detected in macrophages and neutrophils. Our data suggest that activation of innate cellular sources of IL-17A is an essential mediator of macrophage accumulation in CS-exposed lungs. Targeting non-conventional T cell sources of IL-17A may offer an alternative strategy to reduce pathogenic macrophages in COPD
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