86 research outputs found
Transport properties and point contact spectra of Ni_xNb_{1-x} metallic glasses
Bulk resistivity and point contact spectra of Ni_xNb_{1-x} metallic glasses
have been investigated as functions of temperature (0.3-300K) and magnetic
field (0-12T). Metallic glasses in this family undergo a superconducting phase
transition determined by the Nb concentration. When superconductivity was
suppressed by a strong magnetic field, both the bulk sample R(T) and the point
contact differential resistance curves of Ni_xNb_{1-x} showed logarithmic
behavior at low energies, which is explained by a strong electron - "two level
system" coupling. We studied the temperature, magnetic field and contact
resistance dependence of Ni_{44}Nb_{56} point-contact spectra in the
superconducting state and found telegraph-like fluctuations superimposed on
superconducting characteristics. These R(V) characteristics are extremely
sensitive detectors for slow relaxing "two level system" motion.Comment: 4 pages, 5 figure
Size Dependence In The Disordered Kondo Problem
We study here the role randomly-placed non-magnetic scatterers play on the
Kondo effect. We show that spin relaxation effects (with time )in the
vertex corrections to the Kondo self-energy lead to an exact cancellation of
the singular temperature dependence arising from the diffusion poles. For a
thin film of thickness and a mean-free path , disorder provides a
correction to the Kondo resistivity of the form
that explains both the disorder and sample-size depression of the Kondo effect
observed by Blachly and Giordano (PRB {\bf 51}, 12537 (1995)).Comment: 11 pages, LaTeX, 2 Postscript figure
Linear Kondo conductance in a quantum dot
In a tunneling experiment across a quantum dot it is possible to change the
coupling between the dot and the contacts at will, by properly tuning the
trasparency of the barriers and the temperature. Gate voltages allow for
changes of the relative position of the dot addition energies and the Fermi
level of the leads. Here we discuss the two limiting cases: weak and strong
coupling in the tunneling Hamiltonian. In the latter case Kondo resonant
conductance can emerge at low temperature in a Coulomb blockade valley. We give
a pedagogical approach to the single-channel Kondo physics at equilibrium and
review the Nozieres scattering picture of the correlated fixed point. We
emphasize the effect of an applied magnetic field and show how an orbital Kondo
effect can take place in vertical quantum dots tuned both to an even and to an
odd number of electrons at a level crossing. We extend the approach to the
two-channel overscreened Kondo case and discuss recent proposals for detecting
the non-Fermi liquid fixed point which could be reached at strong coupling.Comment: 31 pages, invited review articl
Scanning-helium-ion-beam lithography with hydrogen silsesquioxane resist
A scanning-helium-ion-beam microscope is now commercially available. This microscope can be used to perform lithography similar to, but of potentially higher resolution than, scanning electron-beam lithography. This article describes the control of this microscope for lithography via beam steering/blanking electronics and evaluates the high-resolution performance of scanning helium-ion-beam lithography. The authors found that sub-10 nm-half-pitch patterning is feasible. They also measured a point-spread function that indicates a reduction in the micrometer-range proximity effect typical in electron-beam lithography.National Science Foundation (U.S.). Graduate Research Fellowship Progra
Interference in interacting quantum dots with spin
We study spectral and transport properties of interacting quantum dots with
spin. Two particular model systems are investigated: Lateral multilevel and two
parallel quantum dots. In both cases different paths through the system can
give rise to interference. We demonstrate that this strengthens the multilevel
Kondo effect for which a simple two-stage mechanism is proposed. In parallel
dots we show under which conditions the peak of an interference-induced orbital
Kondo effect can be split.Comment: 8 pages, 8 figure
Stochastic dynamics and mean field approach in a system of three interacting species
The spatio-temporal dynamics of three interacting species, two preys and one
predator, in the presence of two different kinds of noise sources is studied.
To describe the spatial distributions of the species we use a model based on
Lotka-Volterra equations. A correlated dichotomous noise acts on \beta, the
interaction parameter between the two preys, and a multiplicative white noise
affects directly the dynamics of each one of the three species. We study the
time behaviour of the three species in single site for different values of the
multiplicative noise intensity, finding noise-induced oscillations of the three
species densities with an anticorrelated behaviour of the two preys.
Afterwards, by considering a spatially extended system formed by a
two-dimensional lattice with N sites and applying a mean field approach, we get
the corresponding moment equations in Gaussian approximation. Within this
formalism we obtain the time behaviour of the first and second order moments
for different values of multiplicative noise intensity, with \beta(t) subject
to the same dichotomous noise source. Finally, we compare our results with
those obtained by using a coupled map lattice model, consisting of a time
discrete version of the Lotka-Volterra equations.Comment: 21 pages, 7 figures. Submitted to Centr. Eur. J. Phy
VANG-1 and PRKL-1 Cooperate to Negatively Regulate Neurite Formation in Caenorhabditis elegans
Neuritogenesis is a critical early step in the development and maturation of neurons and neuronal circuits. While extracellular directional cues are known to specify the site and orientation of nascent neurite formation in vivo, little is known about the genetic pathways that block inappropriate neurite emergence in order to maintain proper neuronal polarity. Here we report that the Caenorhabditis elegans orthologues of Van Gogh (vang-1), Prickle (prkl-1), and Dishevelled (dsh-1), core components of planar cell polarity (PCP) signaling, are required in a subset of peripheral motor neurons to restrict neurite emergence to a specific organ axis. In loss-of-function mutants, neurons display supernumerary neurites that extend inappropriately along the orthogonal anteroposterior (A/P) body axis. We show that autonomous and non-autonomous gene activities are required early and persistently to inhibit the formation or consolidation of growth cone protrusions directed away from organ precursor cells. Furthermore, prkl-1 overexpression is sufficient to suppress neurite formation and reorient neuronal polarity in a vang-1– and dsh-1–dependent manner. Our findings suggest a novel role for a PCP–like pathway in maintaining polarized neuronal morphology by inhibiting neuronal responses to extrinsic or intrinsic cues that would otherwise promote extraneous neurite formation
Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton
Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing question of the role of the cilium in PCP. Wdpcp, a PCP effector, was recently shown to regulate both ciliogenesis and collective cell movement, but the underlying mechanism is unknown. Here we show Wdpcp can regulate PCP by direct modulation of the actin cytoskeleton. These studies were made possible by recovery of a Wdpcp mutant mouse model. Wdpcp-deficient mice exhibit phenotypes reminiscent of Bardet-Biedl/Meckel-Gruber ciliopathy syndromes, including cardiac outflow tract and cochlea defects associated with PCP perturbation. We observed Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis. Wdpcp is also found in the cytoplasm, where it is localized in the actin cytoskeleton and in focal adhesions. Wdpcp interacts with Sept2 and is colocalized with Sept2 in actin filaments, but in Wdpcp-deficient cells, Sept2 was lost from the actin cytoskeleton, suggesting Wdpcp is required for Sept2 recruitment to actin filaments. Significantly, organization of the actin filaments and focal contacts were markedly changed in Wdpcp-deficient cells. This was associated with decreased membrane ruffling, failure to establish cell polarity, and loss of directional cell migration. These results suggest the PCP defects in Wdpcp mutants are not caused by loss of cilia, but by direct disruption of the actin cytoskeleton. Consistent with this, Wdpcp mutant cochlea has normal kinocilia and yet exhibits PCP defects. Together, these findings provide the first evidence, to our knowledge, that a PCP component required for ciliogenesis can directly modulate the actin cytoskeleton to regulate cell polarity and directional cell migration
Centrioles: active players or passengers during mitosis?
Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as “the organ for cell division”. However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues
Synaptic Wnt signaling—a contributor to major psychiatric disorders?
Wnt signaling is a key pathway that helps organize development of the nervous system. It influences cell proliferation, cell fate, and cell migration in the developing nervous system, as well as axon guidance, dendrite development, and synapse formation. Given this wide range of roles, dysregulation of Wnt signaling could have any number of deleterious effects on neural development and thereby contribute in many different ways to the pathogenesis of neurodevelopmental disorders. Some major psychiatric disorders, including schizophrenia, bipolar disorder, and autism spectrum disorders, are coming to be understood as subtle dysregulations of nervous system development, particularly of synapse formation and maintenance. This review will therefore touch on the importance of Wnt signaling to neurodevelopment generally, while focusing on accumulating evidence for a synaptic role of Wnt signaling. These observations will be discussed in the context of current understanding of the neurodevelopmental bases of major psychiatric diseases, spotlighting schizophrenia, bipolar disorder, and autism spectrum disorder. In short, this review will focus on the potential role of synapse formation and maintenance in major psychiatric disorders and summarize evidence that defective Wnt signaling could contribute to their pathogenesis via effects on these late neural differentiation processes
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