SPIDER4LEGS MOBILE ROBOT DESIGN CONTROLLED BY THE ESP32 PLATFORM

The grazing robot is a dynamic system, consisting of a platform (the body of the robot) and a number of legs with structures similar to the kinematic chains of manipulator robots. Grazing robots can have a redundant number of legs, therefore they can ensure a static stability even if one or more legs are destroyed [10]. The objective of the work is to design a mobile robot controlled with the Arduino board controlled by an ESP 32 logic processor. The robot proposed in the paper is a spider-type robot with four legs, named SPIDER4LEGS. The components used to make the robot are the following: ESP32 development board, ESP ROOM-32, WiFi and Bluetooth BLE, Dual Core; PCA9685 module, I2C interface, 16 CH, servo motor; 12 Servo motors SG90 180 degrees. A possible field of application of these robots is the internal inspection of pipelines transporting petroleum products [7],[8],[9]

MiRNA-Based Therapeutics in Oncology, Realities, and Challenges

As master modulators of the human genome, miRNAs are involved in all cancer hallmarks, disrupting the normal function of their targets. By gaining or losing the function, miRNAs lead to the validation of tumor phenotype, its progression, and metastasis as well as to drug resistance. Increasing the evidence suggests that the modulation of miRNAs in cancer cells, by suppressing the oncogenic miRNAs (oncomiRs) and substituting the deficient tumor suppressive miRNAs (TS-miRNAs), could become a reliable tool for improving the cancer therapy. In this chapter, we will present an up-to-date overview of the role of miRNA-based therapeutics in oncology, highlighting their role in cancer management, how these therapies can be used, and which would be the future challenges related to miRNA-based therapies

Therapeutic Considerations Related to Finasteride Administration in Male Androgenic Alopecia and Benign Prostatic Hyperplasia

Finasteride has been used extensively until now as a relative efficient therapeutic option for male androgenic alopecia and benign prostatic hyperplasia. Unfortunately, over time several concerns appeared regarding the frequency and magnitude of adverse effects, which in some cases have been even irreversible. Herein we review the recent literature on this topic, trying to clarify the current safety profile of Finasteride for these two therapeutic indications. We concluded that Finasteride could be retained as a therapeutic approach for male androgenic alopecia, based on two important reasons. First, a synergistic action between a partial inhibitor of 5α-reductase (Finasteride) and another compound (like Minoxidil) are preferable to a complete suppression of 5α-reductase (see Dutasteride), in order to preserve the important physiological roles of dihydrotestosterone. Second, Finasteride side effects can currently be addressed in part prior to the onset of the therapy, by using information about the patient such as hand preference and sexual orientation to predict the risk of adverse effects

A pedunculated esophageal chondromatous hamartoma in a child

Esophageal tumors are uncommon in pediatric population and most of them are benign. Esophageal hamartomas have been reported extremely rare in children. These can present as intramural tumors of the esophageal wall or as polyps. Dysphagia is the main symptom described in their case, but other specific symptoms are also reported. Such symptoms encountered in clinical practice are represented by obstructive apnea episodes and bradycardia, poor weight gain, epigastric or retrosternal pain, hematemesis or melena, dysphonia or tracheal sounds. Diagnosis can be delayed due to the insidious onset and non-specific symptoms, therefore patient’s compliance to follow-up and broad, careful evaluation are mandatory. Preoperative imagistic assessment is extremely important for a precise definition of the tumor’s anatomical relations, especially when facing large tumors located in the posterior mediastinum. Herein we report a case of a large chondromatous polypoid hamartoma of the esophagus in a 9 years old boy, emphasizing over the diagnosis and surgical challenges we have met, along with comments on illustrative similar cases reported in the literature

THE OPPORTUNITY OF USING CLOUD-BASED COMPUTING IN NUMERICAL SIMULATIONS ON STRUCTURAL ANALYSIS - CASE STUDY

To make the most accurate behavioral assessments of mechanical parts, engineers rely heavily on numerous software solutions. These software solutions are able to solve more or less complex problems with a fairly high degree of accuracy and similarity to physical experiments. The common feature of these software solutions is that they need generous resources from the computer on which they are installed. Can't it be done differently? One possible answer may be the use of cloud-based solutions. The main purpose of this paper is to make a comparison and find the limitations of such a solution relative to the established ones in the field of finite element analysis. Therefore, this paper is a case study in which an industrial component – beam bracket – is subjected to a structural analysis on three different software solutions. The reference systems are: ANSYS, a solution dedicated to finite element analysis and SolidWorks Simulation, a solution often used in industry for the assessment of mechanical structures. The cloud-based solution is SimScale, a software product based on open-source codes: Code_Aster and CalculiX

THE OPPORTUNITY OF USING CLOUD-BASED COMPUTING IN NUMERICAL SIMULATIONS ON STRUCTURAL ANALYSIS - CASE STUDY

To make the most accurate behavioral assessments of mechanical parts, engineers rely heavily on numerous software solutions. These software solutions are able to solve more or less complex problems with a fairly high degree of accuracy and similarity to physical experiments. The common feature of these software solutions is that they need generous resources from the computer on which they are installed. Can't it be done differently? One possible answer may be the use of cloud-based solutions. The main purpose of this paper is to make a comparison and find the limitations of such a solution relative to the established ones in the field of finite element analysis. Therefore, this paper is a case study in which an industrial component – beam bracket – is subjected to a structural analysis on three different software solutions. The reference systems are: ANSYS, a solution dedicated to finite element analysis and SolidWorks Simulation, a solution often used in industry for the assessment of mechanical structures. The cloud-based solution is SimScale, a software product based on open-source codes: Code_Aster and CalculiX

Therapeutic Considerations Related to Finasteride Administration in Male Androgenic Alopecia and Benign Prostatic Hyperplasia

Finasteride has been used extensively until now as a relative efficient therapeutic option for male androgenic alopecia and benign prostatic hyperplasia. Unfortunately, over time several concerns appeared regarding the frequency and magnitude of adverse effects, which in some cases have been even irreversible. Herein we review the recent literature on this topic, trying to clarify the current safety profile of Finasteride for these two therapeutic indications. We concluded that Finasteride could be retained as a therapeutic approach for male androgenic alopecia, based on two important reasons. First, a synergistic action between a partial inhibitor of 5α-reductase (Finasteride) and another compound (like Minoxidil) are preferable to a complete suppression of 5α-reductase (see Dutasteride), in order to preserve the important physiological roles of dihydrotestosterone. Second, Finasteride side effects can currently be addressed in part prior to the onset of the therapy, by using information about the patient such as hand preference and sexual orientation to predict the risk of adverse effects

THE VALORIZING OF DIFFERENT WOODY WASTES AS NATURAL SUBSTRATES FOR INTENSIVE CULTIVATION OF MUSHROOMS

This paper presents the results of laboratory experiments regarding the valorizing of different types of lignocellulosic wastes coming from woody species through controlled cultivation of two mushroom species, namely Ganoderma lucidum and Pleurotus ostreatus. Both mushroom species were cultivated in controlled conditions of temperature, humidity, and aeration in order to get their carpophores. The main aim of this work was focused on finding out the best way to convert the woody wastes into useful food products, such as mushroom fruit bodies, by using them as growing sources for the mentioned edible and medicinal mushrooms. The final produced carpophores were weighted and the results were compared to find out the optimal variant to be applied for intensive cultivation of mushrooms

Continuous renal replacement therapy in cytokine release syndrome following immunotherapy or cellular therapies?

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadRecently, an increasing number of novel drugs were approved in oncology and hematology. Nevertheless, pharmacology progress comes with a variety of side effects, of which cytokine release syndrome (CRS) is a potential complication of some immunotherapies that can lead to multiorgan failure if not diagnosed and treated accordingly. CRS generally occurs with therapies that lead to highly activated T cells, like chimeric antigen receptor T cells or in the case of bispecific T-cell engaging antibodies. This, in turn, leads to a proinflammatory state with subsequent organ damage. To better manage CRS there is a need for specific therapies or to repurpose strategies that are already known to be useful in similar situations. Current management strategies for CRS are represented by anticytokine directed therapies and corticosteroids. Based on its pathophysiology and the resemblance of CRS to sepsis and septic shock, as well as based on the principles of initiation of continuous renal replacement therapy (CRRT) in sepsis, we propose the rationale of using CRRT therapy as an adjunct treatment in CRS where all the other approaches have failed in controlling the clinically significant manifestations.School of Doctoral Studies - Iuliu Hatieganu University Romanian Government Ion Chiricuta Oncology Institute Cluj Napoca Iuliu Hatieganu University of Medicine and Pharmacy Cluj Napoca European Economic Spac