Screening for autism spectrum disorders with the brief infant-toddler social and emotional assessment

Objective: Using parent-completed questionnaires in (preventive) child health care can facilitate the early detection of psychosocial problems and psychopathology, including autism spectrum disorders (ASD). A promising questionnaire for this purpose is the Brief Infant-Toddler Social and Emotional Assessment (BITSEA). The screening accuracy with regard to ASD of the BITSEA Problem and Competence scales and a newly calculated Autism score were evaluated. Method: Data, that was collected between April 2010 and April 2011, from a community sample of 2-year-olds (N = 3127), was combined with a sample of preschool children diagnosed with ASD (N = 159). For the total population and for subgroups by child's gender, area under the Receiver Operating Characteristic (ROC) curve was examined, and across a range of BITSEA Problem, Competence and Autism scores, sensitivity, specificity, positive and negative likelihood ratio's, diagnostic odds ratio and Youden's index were reported. Results: The area under the ROC curve (95% confidence interval, [95%CI]) of the Problem scale was 0.90(0.87-0.92), of the Competence scale 0.93(0.91-0.95), and of the Autism score 0.95(0.93-0.97). For the total population, the screening accuracy of the Autism score was significantly better, compared to the Problem scale. The screening accuracy of the Competence scale was significantly better for girls (AUC = 0.97; 95%CI = 0.95-0.98) than for boys (AUC = 0.91; 95%CI = 0.88-0.94). Conclusion: The results indicate that the BITSEA scales and newly calculated Autism score have good discriminative power to differentiate children with and without ASD. Therefore, the BITSEA may be helpful in the early detection of ASD, which could have beneficial effects on the child's development

Improved Diagnostic Validity of the ADOS Revised Algorithms: A Replication Study in an Independent Sample

Recently, Gotham et al. (2007) proposed revised algorithms for the Autism Diagnostic Observation Schedule (ADOS) with improved diagnostic validity. The aim of the current study was to replicate predictive validity, factor structure, and correlations with age and verbal and nonverbal IQ of the ADOS revised algorithms for Modules 1 and 2 in a large independent Dutch sample (N = 532). Results showed that the improvement of diagnostic validity was most apparent for autism, except in very young or low functioning children. Results for other autism spectrum disorders were less consistent. Overall, these findings support the use of the more homogeneous revised algorithms, with the use of similar items across developmental cells making it easier to compare ADOS scores within and between individuals

Drivers of plant traits that allow survival in wetlands

Plants have developed a suite of traits to survive the anaerobic and anoxic soil conditions in wetlands. Previous studies on wetland plant adaptive traits have focused mainly on physiological aspects under experimental conditions, or compared the trait expression of the local species pool. Thus, a comprehensive analysis of potential factors driving wetland plant adaptive traits under natural environmental conditions is still missing.In this study, we analysed three important wetland adaptive traits, i.e. root porosity, root/shoot ratio and underwater photosynthetic rate, to explore driving factors using a newly compiled dataset of wetland plants. Based on 21 studies at 38 sites across different biomes, we found that root porosity was affected by an interaction of temperature and hydrological regime; root:shoot ratio was affected by temperature, precipitation and habitat type; and underwater photosynthetic rate was affected by precipitation and life form. This suggests that a variety of driving mechanisms affect the expression of different adaptive traits.The quantitative relationships we observed between the adaptive traits and their driving factors will be a useful reference for future global methane and denitrification modelling studies. Our results also stress that besides the traditionally emphasized hydrological driving factors, other factors at several spatial scales should also be taken into consideration in the context of future functional wetland ecology.Environmental Biolog

Diversity in Alzheimer\u27s Disease Drug Trials: The Importance of Eligibility Criteria

INTRODUCTION: To generalize safety and efficacy findings, it is essential that diverse populations are well represented in Alzheimer\u27s disease (AD) drug trials. In this review, we aimed to investigate participant diversity in disease-modifying AD trials over time, and the frequencies of participant eligibility criteria. METHODS: A systematic review was performed using Medline, Embase, the Cochrane Library, and Clinicaltrials.gov, identifying 2247 records. RESULTS: In the 101 included AD trials, participants were predominantly White (median percentage: 94.7%, interquartile range: 81.0-96.7%); and this percentage showed no significant increase or decrease over time (2001-2019). Eligibility criteria such as exclusion of persons with psychiatric illness (78.2%), cardiovascular disease (71.3%) and cerebrovascular disease (68.3%), obligated caregiver attendance (80.2%), and specific Mini-Mental State Examination scores (90.1%; no significant increase/decrease over time) may have led to a disproportionate exclusion of ethnoracially diverse individuals. DISCUSSION: Ethnoracially diverse participants continue to be underrepresented in AD clinical trials. Several recommendations are provided to broaden eligibility criteria

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives