LEVERAGING WI-FI INFRASTRUCTURE FOR INCREASED POWER SAVINGS IN IOT DEVICES

Mining is one of the oldest industries known to man, and it continues to remain essential for the prosperity of modern civilization. Compared to surface mining, a large number of disasters are likely to occur during underground mining. To ensure the safety and security of an underground working environment, it is critical for underground mining operations to employ a robust and efficient monitoring infrastructure. To address that need, techniques are presented herein that support an increase in power savings in Internet of things (IoT) devices by leveraging a Wi-Fi infrastructure to determine when, and how frequently, such devices should wake up to send or receive data. Aspects of the presented techniques employ an access point’s (AP\u27s) channel state information (CSI) data, in conjunction with data from an AP’s on-board sensors (for metrics such as air quality, altimeter, temperature, and humidity), to detect indoor occupancy which, in turn, may drive the Target Wakeup Time (TWT) for selected IoT devices

A study on morphologic and histological pattern of the central nervous system tumors

Background: It has been revealed by International Agency for Research on Cancer that the worldwide incidence rate of CNS tumors in 2002 was 3.7/100,000 population among males and 2.6/100,000 population among females. Central Nervous System (CNS) tumors account for 85% of brain tumors and 15 % of spinal cord tumors, however metastatic tumors are usually extradural. According to the WHO classification tumors of CNS comprise more than 50 clinico-pathological entities. The major categories include the tumors of neuroepithelial tissue, cranial and paraspinal nerves, meninges, sellar region, lymphomas haematopoietic neoplasms, germ cell and metastatic tumors. An understanding of the epidemiology is needed to facilitate prevention, early detection and treatment of CNS tumours.Methods: The study was conducted in the Department of Pathology, Pt. J.N.M. Medical College Raipur, India from January 2009 to August 2017. The present study was a retrospective study, hence H and E section of every case was re-examined and histopathological reports were reviewed. Sections were stained with H&E. Diagnosis is made according to the WHO classification and diagnostic criteria for CNS neoplasms.Results: CNS tumours occur more frequently in the age group of 41-50 years (57 cases -21.1%) followed by 31-40 years (53 cases -19.7%). The most common entity in the present study were tumours of neuroepithelial tissue 127 cases (47.2%) followed by tumors of meninges 59 cases (22%) and nerve sheath tumours 42 cases (15.6%). The tumors of neuroepithelial tissue comprised mainly of astrocytic tumors 86 cases (32%) followed by embryonal tumors 15 cases (5.6%), ependymal tumors 11 cases (4.1%), oligodendroglial tumors 09 cases (3.3%).Conclusions: Within the scope and limitations of the present study we believe that this effort would help in establishing the grounds for future epidemiologic studies that would, eventually, contribute to give insight into the epidemiology of CNS tumors

Abundance of Secondary Metabolites in Human Microbiome

Digitized for IUPUI ScholarWorks inclusion in 2021.Human body harbors the most complicated microbial ecosystem. Bacteria that have co-evolved within a human context have barely been explored for secondary metabolites. These secondary metabolites are hypothesized to possess biological activities significant within the human host context. In our study, we studied conservation profiles of 203 secondary metabolite gene clusters across 16 human body sites and found that gastrointestinal tract and oral sites show the highest conservation for secondary metabolic gene clusters. We observed that majority of highly conserved metabolites belong to pathway type NRPS. Our phylogenetic analysis of highly conserved stool and oral samples revealed abundance of firmicutes, bacteroidetes and actinobacteria phylum

An Enhanced fall detection system with GSM and GPS Technology

Fall-related accident and injury are a standout among the most widely recognized motivations to reason for death and hospitalization among elderly. Falls among older people become a major problem facing hospitals and nursing homes. An enhanced fall detection system is proposed for elderly person monitoring that is based on-body sensor. Various fall-detection solutions have been previously proposed to create a reliable surveillance system for elderly people with high requirements on accuracy. In this paper, an enhanced fall detection system is proposed for elderly person monitoring that is based on smart sensors worn on the body and operating through long distance as well as consumer home networks. The principle behind this work is the detection of changes in the motion and position using the sensor which tracks the acceleration changes in three orthogonal directions. By using MEM's accelerometer sensor is used for determining exact angle of an elderly person with the help of signal magnitude vector (SMV). When the fall is detected the GPS locates the exact fall location and GSM modem is used to transmit the message to the mobile phone of caretakers/relatives of the fallen subjects at that time also send their latitude and longitude value by using GPS. This alert message helps to provide immediate assistance and treatment

Studying drug prescription pattern of dermatology OPD of an Indian tertiary care hospital- a prospective, observational, cross-sectional study

Background: Studying prescription patterns helps prescribers to provide rational and cost-effective medical care. Drugs prescribed for skin disorders by a specialist differ in terms of numbers and the selection of drug class, necessitating periodic prescription audits and drug utilization studies. Methods: This prospective, cross-sectional, observational study was conducted at the dermatology department OPD of Government Medical College, Aurangabad (Maharashtra, India) from January 2021 to May 2021. Digital records of prescription were collected from the hospital management information system (HMIS). Results: N=5338 prescriptions were analysed, 40.89% of patients were from the 21-35 years age group. Polytherapy was 62.96% and monotherapy 36.99%. Drugs prescribed by generic names were 18% and brand names were 82%. Topical drugs constituted 71.67% followed by systemic drugs 28.32% of total prescriptions and the average injectables prescribed per encounter was 0.33%. Antifungals were most prescribed followed by steroids. The average number of drugs prescribed was 1.85 per encounter and the percentage of antibiotic prescriptions was 17.70%. Conclusions: The current study showed that WHO DUS indicators were followed. The results reflect rational prescription of drugs within the available resources

Study of the prescription pattern of anti-depressants in a tertiary care hospital: a prospective observational study

Background: One of the most important public health priorities are psychiatric disorders. Prescribing medications play a crucial role in providing good health care. Therefore, there is a need to understand prescription patterns at regular intervals. Methods: This was a prospective, cross-sectional, observational study conducted at the psychiatry department OPD of Government Medical College, Aurangabad (Maharashtra, India) from January 2021 to June 2022. Records of prescriptions were collected from the hospital management information system. Results: N=417 prescriptions were analysed. The male: female ratio was 1.25. Among total prescriptions analysed, selective serotonin reuptake inhibitors (SSRIs) were the most prescribed drug class (32.18%) followed by benzodiazepines (25.19%) and atypical antipsychotics (19.97%). Drugs prescribed as fixed dose combinations (FDC) were 2.10%. Most of the patients received polytherapy in which most patients constituted of two drug therapy (46.28%) and 34.53% of patients received monotherapy. In the patients managed by monotherapy, SSRIs were the most prescribed (29.16%), followed by atypical anti-psychotics (26.38%) and benzodiazepines (24.30%). Prescriptions with generic names were 93.12%. The average number of drugs per encounter was 1.88. Drugs prescribed from the essential drugs list (India) were 41.66%. Drugs prescribed from the essential medicines list (WHO) were 47%. The total number of prescriptions with injections 0.23%. Conclusions: Prescribing patterns were according to the WHO-DUS parameters. Most patients were prescribed generic medicines. SSRIs, benzodiazepines and tricyclic antidepressants were the most prescribed drug class

CO-CRYSTALS OF ACTIVE PHARMACEUTICAL INGREDIENT-IBUPROFEN LYSINE

Objective: Co-crystal is defined as a crystalline complex of two or more neutral molecules bound together primarily by hydrogen bonding or other non-covalent interactions. The pharmaceutical co-crystal involves crystal lattice arrangement between an Active Pharmaceutical Ingredient (API) with another pharmaceutically acceptable molecule. Co-crystals of API are preferred since they depict improved solubility, dissolution, stability, compressibility in comparison with API. Ibuprofen lysine (IL), frequently used analgesic and the anti-inflammatory drug has poor aqueous solubility and compressibility. This work shows the feasibility and optimal conditions for the preparation of co-crystals of ibuprofen lysine using Polyvivylpyrrolidone K25 (PK 25) and Polyvivylpyrrolidone K30 (PK 30) as co-formers. Methods: In this study, we prepared and studied the solubility, drug content, flow properties, physical stability of novel co-crystal, consisting of IL and PK 25/PK 30. The co-crystal IL: PK 30 (at a molar ratio of 0.29:0.5) and IL: PK 25 (at a molar ratio of 0.58:1) were characterized by X-ray analysis, infrared spectroscopy and thermal analysis. Furthermore, the tablet formulations of the co-crystals were subjected to in vitro dissolution and in vivo analgesic activity, with the goal of comparing the co-crystals with IL and the marketed tablet of ibuprofen (Brufen®) respectively. Results: The IL: PK co-crystals demonstrated superior solubility and the dissolution properties over IL. The compression properties of the co-crystals were similar to IL. The co-crystals exhibited higher analgesic activity than the marketed tablet.  Conclusion: The results indicated the use of PK 25 and PK 30 as safe and promising co-crystal formers

Knowledge, attitude, and perception of prescribers about antimicrobial stewardship in a tertiary care hospital

Background: Irrational antimicrobial use has contributed to amplification and spread of antimicrobial resistance (AMR). Antimicrobial stewardship by healthcare personnel can reduce AMR. The World Health Organization (WHO) has established a worldwide action plan to address AMR, including free online availability of open WHO courses. So, our study sought to ascertain knowledge, attitude, and practice (KAP) of healthcare personnel concerning AMS at tertiary care hospital. Methods: Study was conducted as a KAP survey among practitioners (faculty, senior and junior residents) from several departments of Government Medical College, Aurangabad, Maharashtra. A validated questionnaire with 30 questions was prepared and distributed to 100 participants. The data collected in MS excel was analyzed with descriptive statistics and results expressed as mean and standard deviation, frequencies, and percentages. Results: Response rate was 16.7% (n=100). Knowledge on AMS was observed among doctors’ with >80% near correct responses in each question. Insignificant knowledge gap was found comparing between faculty members, senior residents, and junior residents (p>0.005) in the knowledge, attitude and practice of antimicrobial use. All participants felt that ASP is a requirement of hospital, and it minimizes healthcare expenditures and negative impacts of inappropriate AM prescribing. Conclusions: All HCPs have a knowledge gap on ASP, although there is no significant difference in knowledge, attitude, and practice of antimicrobial use between faculty members and senior and junior residents. This demonstrates importance of faculty members taking lead in incorporating more practice and education into ASP