Statistical measurement of educational development of school education at state level

Education especially school education is one of the very important components of social development. Since independence, education has been visualized in government policies as a precursor to national development as well as to better quality of life. Due to the initiative taken by the states and centre, education system in India has expanded exponentially over the past years, but its current achievement is grossly inadequate in realizing its potential greatness. Social development is not pre-determined but is a continuous proces

Stress, anxiety, and depression among the health-care workforce during the COVID-19 pandemic: A cross-sectional study

Aim: The study was aimed at calculating the levels of stress, anxiety, and depression among medical and health-care workers working in hospitals that catered to COVID-19 patients. Methodology: A total of 471 healthcare and medical personnel filled up an online socio-demographic pro forma and answered the Depression, Anxiety, and Stress scale. The data were analyzed using descriptive statistics and Chi-square test where appropriate. Results: The sample consisted of medical personnel and nurses. Majority were married and male. The levels of anxiety and stress were reported to be higher in males while depression was reported higher in females. Being unmarried and not having children were factors that showed higher depression levels while no socio-demographic factors showed a trend with anxiety and stress. Conclusion: Depression, anxiety, and stress are common in medical personnel and health-care workers working in the COVID-19 pandemic. Sound mental health interventions for these workers and large studies in specific populations are needed to corroborate these findings

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

https://researchrepository.wvu.edu/wvu_herbwvfern/2465/thumbnail.jp

Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

Several polar heteroaromatic acetic acids and their piperidine amides were synthesized and evaluated as ghrelin or type 1a growth hormone secretagogue receptor (GHS-R1a) inverse agonists. Efforts to improve pharmacokinetic and safety profile was achieved by modulating physicochemical properties and, more specifically, emphasizing increased polarity of our chemical series. <i>ortho</i>-Carboxamide containing compounds provided optimal physicochemical, pharmacologic, and safety profile. pH-dependent chemical stability was also assessed with our series

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

The identification of potent, highly selective orally bioavailable ghrelin receptor inverse agonists from a spiro-azetidino-piperidine series is described. Examples from this series have promising in vivo pharmacokinetics and increase glucose-stimulated insulin secretion in human whole and dispersed islets. A physicochemistry-based strategy to increase lipophilic efficiency for ghrelin receptor potency and retain low clearance and satisfactory permeability while reducing off-target pharmacology led to the discovery of <b>16h</b>. Compound <b>16h</b> has a superior balance of ghrelin receptor pharmacology and off-target selectivity. On the basis of its promising pharmacological and safety profile, <b>16h</b> was advanced to human clinical trials