De ontwikkeling van de tuinbouw in de veenstreek

Het onderzoek bleef beperkt tot de gemeenten Ter Aar, Nieuwveen en Uithoorn omdat men de indruk had dat een stagnatie in de ontwikkeling zich vooral voordeed in Ter Aar en omgeving

Reply to Xiangyang Yao, Chen Duan, Bo Li, Xiaoliang Wu and Hua Xu's Letter to the Editor Re: Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, et al. Robot-assisted Prostate-specific Membrane Antigen-radioguided Salvage Surgery in Recurrent Prostate Cancer Using a DROP-IN Gamma Probe: The First Prospective Feasibility Study. Eur Urol 2022;82:97-105

Radiolog

Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) can achieve remarkable responses in urothelial cancer (UC), which may depend on tumor microenvironment (TME) characteristics. However, the relationship between the TME, usually characterized by immune cell density, and response to ICI is unclear. Here, we quantify the TME immune cell densities and spatial relationships (SRs) of 24 baseline UC samples, obtained before pre-operative combination ICI treatment, using multiplex immunofluorescence. We describe SRs by approximating the first nearest-neighbor distance distribution with a Weibull distribution and evaluate the association between TME metrics and ipilimumab+nivolumab response. Immune cell density does not discriminate between response groups. However, the Weibull SR metrics of CD8+ T cells or macrophages to their closest cancer cell positively associate with response. CD8+ T cells close to B cells are characteristic of non-response. We validate our SR response associations in a combination ICI cohort of head and neck tumors. Our data confirm that SRs, in contrast to density metrics, are strong biomarkers of response to pre-operative combination ICIs. Otorhinolaryngolog

Use of gallium-68 prostate-specific membrane antigen positron-emission tomography for detecting lymph node metastases in primary and recurrent prostate cancer and location of recurrence after radical prostatectomy: an overview of the current literature

Objectives: To review the literature to determine the sensitivity and specificity of gallium-68 prostate-specific membrane antigen (68Ga-PSMA) positron-emission tomography (PET) for detecting pelvic lymph node metastases in patients with primary prostate cancer (PCa), and the positive predictive value in patients with biochemical recurrence (BCR) after initial curative treatment, and, in addition, to determine the detection rate and management impact of 68Ga-PSMA PET in patients with BCR after radical prostatectomy (RP). Materials and Methods: We performed a comprehensive literature search. Search terms used in MEDLINE, EMBASE and Science Direct were ‘(PSMA, 68Ga-PSMA, 68Gallium-PSMA, Ga-68-PSMA or prostate-specific membrane antigen)’ and ‘(histology, lymph node, staging, sensitivity, specificity, positive predictive value, recurrence, recurrent or detection)’. Relevant abstracts were reviewed and full-text articles obtained where possible. References to and from obtained articles were searched to identify further relevant articles. Results: Nine retrospective and two prospective studies described the sensitivity and specificity of 68Ga-PSMA PET for detecting pelvic lymph node metastases before initial treatment, which ranged from 33.3% to 100% and 80% to 100%, respectively. In eight retrospective studies, the positive predictive value of 68Ga-P

Rhodophyta de ambientes lóticos de Unidades de Conservação da região Sul do Brasil

Species of Rhodophyta from 10 Conservation Units from the south region of Brazil were surveyed. The samplings were carried out in 105 stream reaches, consisting of 10 m length transects. The floristic survey involved 80 populations, representing three genera, Batrachospermum, Kumanoa and Hildenbrandia plus the 'Chantransia' stages. Batrachospermum was represented by five species (B. arcuatum Kylin, B. atrum (Hudson) Harvey, B. helminthosum Bory, B. keratophytum Bory and B. puiggarianum Grunow in Wittrock & Nordstedt). The genus Kumanoa was represented by K. abilii (Reis) Necchi Junior & Vis and K. ambigua (Montagne) Entwisle et al., while Hildenbrandia only by H. angolensis W.West & G.S.West. Our results confirm Batachospermum as the best represented genus, in terms of species number, among freshwater Rhdophyta. B. arcuatum was a new record for the south region of Brazil, thus extending its austral distribution range.Espécies de Rhodophyta de 10 Unidades de Conservação da região Sul do Brasil foram investigadas. As amostragens foram conduzidas em 105 segmentos de riachos consistindo em transeções de 10 m de comprimento. O levantamento florístico resultou em 80 populações representando três gêneros, Batrachospermum, Kumanoa e Hildenbrandia, além do estágios ‘Chantransia’. Batrachospermum foi representado por cinco espécies (B. arcuatum Kylin, B. atrum (Hudson) Harvey, B. helminthosum Bory, B. keratophytum Bory, B. puiggarianum Grunow in Wittrock & Nordstedt). O gênero Kumanoa foi representado por K. abilii (Reis) Necchi Júnior & Vis e K. ambigua (Montagne) Entwisle et al., enquanto Hildenbrandia exclusivamente por H. angolensis W. West & G.S. West. Nossos resultados confirmam Batachospermum como o gênero melhor representado, em termos de número de espécies, entre as Rhdophyta de água doce. Batrachospermum arcuatum foi registrado pela primeira vez na região Sul do Brasil, ampliando assim, o limite austral de sua distribuição.Univ Estadual Paulista UNESP, FCL, BR-19806900 Assis, SP, BrazilUniv Fed Integracao Latino Amer UNILA, Foz do Iguacu, PR, BrazilUniv Estadual Paulista UNESP, Dept Zool & Bot, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Estadual Paulista UNESP, FCL, BR-19806900 Assis, SP, BrazilUniv Estadual Paulista UNESP, Dept Zool & Bot, BR-15054000 Sao Jose do Rio Preto, SP, Brazi

Macroalgas em nascentes e arredores de riachos na região noroeste do estado de São Paulo

Macroalgas são organismos tipicamente bentônicos, constituídos por um talo maduro, discreto e reconhecível a olho nu, cuja identificação microscópica é necessária. Diversos estudos foram realizados visando o conhecimento taxonômico em riachos brasileiros, no entanto, são raros os trabalhos que abordam as algas que se desenvolvem nas nascentes destes riachos. de fevereiro a setembro/2007 coletas mensais foram realizadas em nascentes e em suas imediações (solos úmidos dos afloramentos d'água) de quatro riachos na região noroeste do estado de São Paulo. O levantamento taxonômico resultou na identificação de 13 espécies, sendo 54% dos táxons pertencentes a Cyanophyta e 46% a Chlorophyta. Cylindrospermum gorakhpurense, Mougeotia gotlandica, Spirogyra gallica e S. taftiana são registradas pela primeira vez para o Brasil. A flora aquática encontrada diferiu da regional devido à presença de organismos da família Zygnemataceae (Chlorophyta) em estágio reprodutivo. Este tipo de hábitat mostrou-se especialmente favorável à reprodução das Zygnemataceae.Macroalgae are typically benthic organisms that a mature, discreet and recognizable naked eye thallus, and microscopic identification is necessary. Several studies have been carried out aiming to the taxonomic knowledge in Brazilian streams, however works dealing with algae from springs are rare. Monthly sampling were carried out from February to September/2007 in springs and the surrounding (humid soil near the springs) of four streams in the northwestern region of São Paulo State. The floristic survey resulted in the identification of 13 species, being 54% of taxa belong Cyanophyta and 46% to Chlorophyta. Cylindrospermum gorakhpurense, Mougeotia gotlandica, Spirogyra gallica and S. taftiana were recorded for the first time to Brazil. The aquatic flora differed from the regional records due to presence of organisms of Zygnemataceae family (Chlorophyta) in reproductive stage. This type of habitat revealed to be very favorable to the Zygnemataceae reproduction.Universidade Estadual Paulista Departamento de Zoologia e BotânicaUniversidade Estadual Paulista Departamento de Zoologia e Botânic

Flora de comunidades de macroalgas lóticas de fragmentos florestais remanescentes da região noroeste do Estado de São Paulo, Brasil

Foram amostrados 17 riachos, em 12 fragmentos durante a estação seca (junho a agosto de 2007 e de 2008). Foram identificadas 16 espécies de macroalgas, pertencentes a 14 gêneros. Cyanophyta e Chlorophyta foram os grupos mais representativos (44 e 38%, respectivamente), seguidos por Rhodophyta (12%) e Heterokontophyta (6%). O número global de espécies foi baixo, fato atribuído à predominância de substrato areno-argiloso (65%) e de trechos sombreados (53%). A maioria das espécies (69%) ocorreu exclusivamente em um único riacho, padrão frequentemente observado para macroalgas lóticas. Vaucheria pseudogeminata foi reportada pela primeira vez para o Brasil e Trichocoleus sociatus para a região noroeste do Estado de São Paulo. Comparando a flora de macroalgas encontrada com aquelas de outras regiões/biomas do Estado de São Paulo, notou-se maior semelhança com Floresta Tropical (56% espécies em comum), conforme esperado, por ser o bioma mais próximo e composto também por Floresta Estacional Semidecidual.Seventeen streams in 12 forest fragments were sampled during the dry season (June to August of 2007 and of 2008). Sixteen species belonging to 14 genera were found. Cyanophyta and Chlorophyta were the best represented algal division (44 and 38%, respectively), followed by Rhodophyta (12%) and Heterokontophyta (6%). Global species number was low, probably due to predominance of sand-clay substrates (65%) and of shaded stream segments (53%). Most species (69%) occurred in only one stream, a pattern often observed in lotic macroalgal communities. Vaucheria pseudogeminata was reported for the first time for Brazil, whereas Trichocoleus sociatus for this region. Comparing these macroalgal flora with those from other biomes of São Paulo State, the highest similarity was with Tropical Forest (56% in common), as expected because it is the nearest biome and also constituted by Semideciduous Seasonal Forest.Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências, Letras e Ciências Exatas Departamento de Zoologia e BotânicaUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências, Letras e Ciências Exatas Departamento de Zoologia e Botânic

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo