Pediatric Nasal Lobular Capillary Hemangioma

Background. LCH is a benign vascular growth of the skin and mucous membranes commonly affecting the head and neck. Since it was first described in the nineteenth century, this entity has been variously known as “human botryomycosis” and “pyogenic granuloma.” The shifting nomenclature reflects an evolving understanding of the underlying pathogenesis. We review the histopathology of and current epidemiological data pertaining to LCH which suggests that the development of these lesions may involve a hyperactive inflammatory response influenced by endocrine factors. We report two new cases of pediatric lobular capillary hemangioma (LCH) of the nasal cavity and review current theories regarding the etiology, diagnosis, and treatment of nasal LCH. Methods. Retrospective case series. Case Series. Two adolescent females presented with symptoms of recurrent epistaxis, nasal obstruction, and epiphora. Both patients underwent computed tomography imaging and biopsy of their intranasal mass. The tumors were excised using image-guided transnasal endoscopic technique. Seven other cases of nasal LCH have been reported to date in the pediatric population. Conclusion. Nasal LCH is a rare cause of an intranasal mass and is associated with unilateral epistaxis, nasal obstruction, and epiphora. We advocate for image-guided endoscopic excision of LCH in the adolescent population

Detection of malicious http requests using machine learning algorithms

The goal of this paper is to create machine learning models, which are capable to detect malicious HTTP requests. A review of literature for machine learning application in detection of malicious HTTP requests is performed. Different machine learning models are created using these machine learning algorithms: One class SVM, SVM, decision trees, random forest. Models were trained using two different datasets (“CSIC 2010” and “ECML/PKDD 2007”) and three feature extraction techniques were tested. “ModSecurity” web application firewall was put to test against same datasets. The comparative analysis of created models and “ModSecurity” web application firewall is performed: the highest detection rate and relatively low false positive rate was achieved by random forest algorithm on both datasets

Degree of the product of two algebraic numbers one of which is of prime degree

Let α and β be two algebraic numbers such that deg(α)=m and deg(β)=p, where p is a prime number not dividing m. This research is focused on the following two objectives: to discover new conditions under which deg(αβ)=mp ; to determine the complete list of values deg(αβ) can take. With respect to the first question, we find that if the minimal polynomial of β over Q is neither xp+c nor x2+cx+c2, then necessarily deg(αβ)=mp and αβ is a primitive element of Q(α,β). This supplements some earlier results by Weintraub. With respect to the second question, we determine that if p>2 and p−1 divides m, then for every divisor k of p−1, there exist α and β such that deg(αβ)=mp/k

Information technology risk management framework

By this work we present an IT risk management system, which is capable to model and manage risks that arise from IT wich are related with IS downtimes and slow response times. The system is implemented by using a proposed neural network architecture as a heart of the modeling engine. It is trained with accumulated datasets from existing information systems. The user shows for the system which statistical data time series one needs to model – i.e. the one which represents the risk (like server load, IS response time, etc.). The system automatically determines correlated statistical time series, groups them and creates a separate model for each group – this model generalizes until then unknown relationship between time series by invoking neural network. The model then accepts values of the input parameters and the system models the value of the risk parameter. Experiments have shown that the proposed system can be successfully used in a mixed IT environment and can be rewarding for one who tracks IT risks coming from various IT and IS components

A degree problem for two algebraic numbers of degree p+1 for their product and sum

In this thesis the following result is proved: let p be a prime and k a positive integer. If p+1≠k and p+1≠2k then the triplet (p+1,p+1,kp) is not sum-feasible and not product-feasible, i.e. there are no three algebraic numbers α, β, γ of degrees p+1, p+1, kp respectively such that α+β+γ=0 or αβγ=1

Severe Obstructive Sleep Apnea in a Child With Goldenhar Syndrome and Nasal Obstruction.

A 4-year-old boy with Goldenhar syndrome and severe obstructive sleep apnea does not tolerate nasal continuous positive airway pressure. Evaluation with imaging showed nasal obstruction with an inverted tooth. This case illustrates the importance of personalized evaluation and treatment plan in a child with Goldenhar syndrome

Injection laryngoplasty in children with cystic fibrosis and abnormal swallow

OBJECTIVE: Children with cystic fibrosis (CF) are uniquely vulnerable to the pulmonary complications of chronic aspiration. We present a case series of children with CF and evidence of chronic aspiration who underwent injection laryngoplasty to improve the safety and efficacy of their swallow. STUDY DESIGN: Retrospective chart review. SETTING: Tertiary care children\u27s hospital. METHODS/SUBJECTS: A chart review was performed on three consecutive cases of children with CF and evidence of aspiration on modified barium swallow (MBS) evaluated at a tertiary care, academic children\u27s medical center. RESULTS: Three patients with CF underwent injection laryngoplasty for evidence of aspiration or laryngeal penetration on MBS evaluation. Normal laryngeal anatomy was identified intraoperatively in each case. At the time of the procedure, patients were 22 months, 70 months, and 24 months old, and follow-up information was available for 7 months, 11 months, and 12 months post-procedure, respectively. Presenting symptoms included chronic cough, cough with oral liquids, and recurrent pneumonia. Each patient underwent successful injection into the interarytenoid space. Post-operatively, modified barium swallow demonstrated resolution of aspiration or penetration in all patients. No procedure-related complications were encountered. CONCLUSION: Patients with CF are highly susceptible to pulmonary infections, and aggressive treatment of chronic aspiration is often necessary. Injection laryngoplasty may be effective in normalizing swallowing in these children. Future study will elucidate the duration of effect and if this technique improves long-term pulmonary outcomes in CF patients