85 research outputs found
Psychopatholgy, fundamental assumptions and CD-4 T lymphocyte counts in HIV-positive patients
Objective: Key words: Fundamental Assumptions; HIV; PsychopathologyWe investigated whether psychopathology in HIV-positive patients was associated with more negative fundamental assumptions than in healthy controls. In addition, we explored whether psychopathology and negative fundamental assumptions in HIV-positive patients were associated with lower CD4 T-lymphocyte counts. Method: Self-rating questionnaires to assess depressive symptoms, posttraumatic stress symptoms, alcohol abuse, general psychopathology and fundamental assumptions, were completed by 123 HIV-positive patients and 84 uninfected clinic attendees at three primary health care clinics in the Western Cape, South Africa. CD4 T-lymphocyte counts were obtained from chart records. Results: HIV-positive patients reported more depressive and posttraumatic symptoms than uninfected individuals. However when controlling for socio-economic status, the number of traumatic events experienced and other potential confounds, no differences remained. Fundamental assumptions (FA) were mainly positive in both HIV-positive patients and controls and no correlations were found between fundamental assumptions, psychiatric symptoms and CD4 levels. However, in infected patients FA and psychopathology were negatively associated with all participants scoring in the positive range of the FA scale. Conclusion: The positive scores on the FA scale indicate that positive assumptions are related to less psychopathology. Longitudinal studies investigating the association between the valence of fundamental assumptions and HIV morbidity are needed
Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet
Background. Dietary polyunsaturated fatty acids (PUFA), in particular the long chain marine fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA), are linked to many health benefits in humans and in animal models. Little is known of the molecular response to DHA and EPA of the small intestine, and the potential contribution of this organ to the beneficial effects of these fatty acids. Here, we assessed gene expression changes induced by DHA and EPA in the wildtype C57BL/6J murine small intestine using whole genome microarrays and functionally characterized the most prominent biological process. Results. The main biological process affected based on gene expression analysis was lipid metabolism. Fatty acid uptake, peroxisomal and mitochondrial beta-oxidation, and omega-oxidation of fatty acids were all increased. Quantitative real time PCR, and -in a second animal experiment- intestinal fatty acid oxidation measurements confirmed significant gene expression differences and showed in a dose-dependent manner significant changes at biological functional level. Furthermore, no major changes in the expression of lipid metabolism genes were observed in the colon. Conclusion. We show that marine n-3 fatty acids regulate small intestinal gene expression and increase fatty acid oxidation. Since this organ contributes significantly to whole organism energy use, this effect on the small intestine may well contribute to the beneficial physiological effects of marine PUFAs under conditions that will normally lead to development of obesity, insulin resistance and diabete
A new paediatric formulation of valaciclovir : development and bioequivalence assessment
Peer reviewedPostprin
UV Spectropolarimetry with Polstar: Massive Star Binary Colliding Winds
The winds of massive stars are important for their direct impact on the
interstellar medium, and for their influence on the final state of a star prior
to it exploding as a supernova. However, the dynamics of these winds is
understood primarily via their illumination from a single central source. The
Doppler shift seen in resonance lines is a useful tool for inferring these
dynamics, but the mapping from that Doppler shift to the radial distance from
the source is ambiguous. Binary systems can reduce this ambiguity by providing
a second light source at a known radius in the wind, seen from orbitally
modulated directions. From the nature of the collision between the winds, a
massive companion also provides unique additional information about wind
momentum fluxes. Since massive stars are strong ultraviolet (UV) sources, and
UV resonance line opacity in the wind is strong, UV instruments with a high
resolution spectroscopic capability are essential for extracting this dynamical
information. Polarimetric capability also helps to further resolve ambiguities
in aspects of the wind geometry that are not axisymmetric about the line of
sight, because of its unique access to scattering direction information. We
review how the proposed MIDEX-scale mission Polstar can use UV
spectropolarimetric observations to critically constrain the physics of
colliding winds, and hence radiatively-driven winds in general. We propose a
sample of 20 binary targets, capitalizing on this unique combination of
illumination by companion starlight, and collision with a companion wind, to
probe wind attributes over a range in wind strengths. Of particular interest is
the hypothesis that the radial distribution of the wind acceleration is altered
significantly, when the radiative transfer within the winds becomes optically
thick to resonance scattering in multiple overlapping UV lines.Comment: 26 pages, 12 figures, Review in a topical collection series of
Astrophysics and Space Sciences on the proposed Polstar satellite. arXiv
admin note: substantial text overlap with arXiv:2111.1155
Catching Element Formation In The Act
Gamma-ray astronomy explores the most energetic photons in nature to address
some of the most pressing puzzles in contemporary astrophysics. It encompasses
a wide range of objects and phenomena: stars, supernovae, novae, neutron stars,
stellar-mass black holes, nucleosynthesis, the interstellar medium, cosmic rays
and relativistic-particle acceleration, and the evolution of galaxies. MeV
gamma-rays provide a unique probe of nuclear processes in astronomy, directly
measuring radioactive decay, nuclear de-excitation, and positron annihilation.
The substantial information carried by gamma-ray photons allows us to see
deeper into these objects, the bulk of the power is often emitted at gamma-ray
energies, and radioactivity provides a natural physical clock that adds unique
information. New science will be driven by time-domain population studies at
gamma-ray energies. This science is enabled by next-generation gamma-ray
instruments with one to two orders of magnitude better sensitivity, larger sky
coverage, and faster cadence than all previous gamma-ray instruments. This
transformative capability permits: (a) the accurate identification of the
gamma-ray emitting objects and correlations with observations taken at other
wavelengths and with other messengers; (b) construction of new gamma-ray maps
of the Milky Way and other nearby galaxies where extended regions are
distinguished from point sources; and (c) considerable serendipitous science of
scarce events -- nearby neutron star mergers, for example. Advances in
technology push the performance of new gamma-ray instruments to address a wide
set of astrophysical questions.Comment: 14 pages including 3 figure
Ultraviolet spectropolarimetry: conservative and nonconservative mass transfer in OB interacting binaries
peer reviewe
Ultraviolet spectropolarimetry: conservative and nonconservative mass transfer in OB interacting binaries
peer reviewe
Distinct Loci in the CHRNA5 / CHRNA3 / CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking
Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. Of the few reports that have focused on early smoking behaviors, association results have been mixed. This meta-analysis examines early smoking phenotypes and SNPs in the gene cluster to determine: (1) whether the most robust association signal in this region (rs16969968) for other smoking behaviors is also associated with early behaviors, and/or (2) if additional statistically independent signals are important in early smoking. We focused on two phenotypes: age of tobacco initiation (AOI) and age of first regular tobacco use (AOS). This study included 56,034 subjects (41 groups) spanning nine countries and evaluated five SNPs including rs1948, rs16969968, rs578776, rs588765, and rs684513. Each dataset was analyzed using a centrally generated script. Meta-analyses were conducted from summary statistics. AOS yielded significant associations with SNPs rs578776 (beta = 0.02, P = 0.004), rs1948 (beta = 0.023, P = 0.018), and rs684513 (beta = 0.032, P = 0.017), indicating protective effects. There were no significant associations for the AOI phenotype. Importantly, rs16969968, the most replicated signal in this region for nicotine dependence, cigarettes per day, and cotinine levels, was not associated with AOI (P = 0.59) or AOS (P = 0.92). These results provide important insight into the complexity of smoking behavior phenotypes, and suggest that association signals in the CHRNA5/A3/B4 gene cluster affecting early smoking behaviors may be different from those affecting the mature nicotine dependence phenotype
Increased Genetic Vulnerability to Smoking at CHRNA5 in Early-Onset Smokers
Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968
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