Results of the simulations of the petal/lens as part of the LAUE project

In the context of the LAUE project for focusing hard X-/gamma rays, a petal of the complete lens is being assembled at the LARIX facility in the Department of Physics and Earth Science of the University of Ferrara. The lens petal structure is composed of bent Germanium and Gallium Arsenide crystals in transmission geometry. We present the expectations derived from a mathematical model of the lens petal. The extension of the model for the complete LAUE project in the 90 -- 600 keV energy range will be discussed as well. A quantitative analysis of the results of these simulations is also presented.Comment: 12 pages, 26 figures, SPIE optics + Photonics conference 2013, Vol: 886

Explaining Deep Face Algorithms through Visualization: A Survey

Although current deep models for face tasks surpass human performance on some benchmarks, we do not understand how they work. Thus, we cannot predict how it will react to novel inputs, resulting in catastrophic failures and unwanted biases in the algorithms. Explainable AI helps bridge the gap, but currently, there are very few visualization algorithms designed for faces. This work undertakes a first-of-its-kind meta-analysis of explainability algorithms in the face domain. We explore the nuances and caveats of adapting general-purpose visualization algorithms to the face domain, illustrated by computing visualizations on popular face models. We review existing face explainability works and reveal valuable insights into the structure and hierarchy of face networks. We also determine the design considerations for practical face visualizations accessible to AI practitioners by conducting a user study on the utility of various explainability algorithms

Low-Cost Transfer Learning of Face Tasks

Do we know what the different filters of a face network represent? Can we use this filter information to train other tasks without transfer learning? For instance, can age, head pose, emotion and other face related tasks be learned from face recognition network without transfer learning? Understanding the role of these filters allows us to transfer knowledge across tasks and take advantage of large data sets in related tasks. Given a pretrained network, we can infer which tasks the network generalizes for and the best way to transfer the information to a new task

Low-Cost Transfer Learning of Face Tasks

Do we know what the different filters of a face network represent? Can we use this filter information to train other tasks without transfer learning? For instance, can age, head pose, emotion and other face related tasks be learned from face recognition network without transfer learning? Understanding the role of these filters allows us to transfer knowledge across tasks and take advantage of large data sets in related tasks. Given a pretrained network, we can infer which tasks the network generalizes for and the best way to transfer the information to a new task. We demonstrate a computationally inexpensive algorithm to reuse the filters of a face network for a task it was not trained for. Our analysis proves these attributes can be extracted with an accuracy comparable to what is obtained\ud with transfer learning, but 10 times faster. We show that the information about other tasks is present in relatively small number of filters. We use these insights to do task specific pruning of a pretrained network. Our method gives significant compression ratios with reduction in size of 95% and computational reduction of 60

Impact of KRAS mutation status on the efficacy of immunotherapy in lung cancer brain metastases

Immune checkpoint inhibitors (ICIs) have resulted in improved outcomes in non-small cell lung cancer (NSCLC) patients. However, data demonstrating the efficacy of ICIs in NSCLC brain metastases (NSCLCBM) is limited. We analyzed overall survival (OS) in patients with NSCLCBM treated with ICIs within 90 days of NSCLCBM diagnosis (ICI-90) and compared them to patients who never received ICIs (no-ICI). We reviewed 800 patients with LCBM who were diagnosed between 2010 and 2019 at a major tertiary care institution, 97% of whom received stereotactic radiosurgery (SRS) for local treatment of BM. OS from BM was compared between the ICI-90 and no-ICI groups using the Log-Rank test and Cox proportional-hazards model. Additionally, the impact of KRAS mutational status on the efficacy of ICI was investigated. After accounting for known prognostic factors, ICI-90 in addition to SRS led to significantly improved OS compared to no-ICI (12.5 months vs 9.1, p \u3c 0.001). In the 109 patients who had both a known PD-L1 expression and KRAS status, 80.4% of patients with KRAS mutation had PD-L1 expression vs 61.9% in wild-type KRAS patients (p = 0.04). In patients without a KRAS mutation, there was no difference in OS between the ICI-90 vs no-ICI cohort with a one-year survival of 60.2% vs 54.8% (p = 0.84). However, in patients with a KRAS mutation, ICI-90 led to a one-year survival of 60.4% vs 34.1% (p = 0.004). Patients with NSCLCBM who received ICI-90 had improved OS compared to no-ICI patients. Additionally, this benefit appears to be observed primarily in patients with KRAS mutations that may drive the overall benefit, which should be taken into account in the development of future trials

Technology Pipeline for Large Scale Cross-Lingual Dubbing of Lecture Videos into Multiple Indian Languages

Cross-lingual dubbing of lecture videos requires the transcription of the original audio, correction and removal of disfluencies, domain term discovery, text-to-text translation into the target language, chunking of text using target language rhythm, text-to-speech synthesis followed by isochronous lipsyncing to the original video. This task becomes challenging when the source and target languages belong to different language families, resulting in differences in generated audio duration. This is further compounded by the original speaker's rhythm, especially for extempore speech. This paper describes the challenges in regenerating English lecture videos in Indian languages semi-automatically. A prototype is developed for dubbing lectures into 9 Indian languages. A mean-opinion-score (MOS) is obtained for two languages, Hindi and Tamil, on two different courses. The output video is compared with the original video in terms of MOS (1-5) and lip synchronisation with scores of 4.09 and 3.74, respectively. The human effort also reduces by 75%

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely