Parametric and numerical modeling tools to forecast hydrogeological impacts of a tunnel

The project of interest involving a hydroelectrical diversion tunnel through a crystalline rock massif in the Alps required a detailed hydrogeological study to forecast the magnitude of water inflows within the tunnel and possible effects on groundwater flow The tunnel exhibits a length of 9.5 km and is located on the right side of the Toce River in Crevoladossola (Verbania Province, Piedmont region, northern Italy). Under the geological framework of the Alps, the tunnel is located within the Lower Penninic Frappes in the footwall of the Simplon Normal Fault, and the geological succession is mostly represented by Antigorio gneiss (metagranites) and Baceno metasediments (metacarbonates). Due to the presence of important mineralized springs for commercial mineral water purposes, the above mentioned hydrogeological study focused on both quantity and quality aspects via rainfall data analysis, monitoring of major spring flow rates, monitoring of hydraulic heads and pumping rates of existing wells/boreholes, hydrochemical and isotopic analysis of springs and boreholes and hydraulic tests (Lefranc and Lugeon). The resulting conceptual model indicated dominant low-permeability (aquitard) behavior of the gneissic rock masses, except under conditions of intense fracturing due to tectonization, and aquifer behavior of the metasedimentary rocks, particularly when interested by dissolution. Groundwater flow systems are mainly controlled by gravity. The springs located near the Toce River were characterized by high mineralization and isotopic ratios, indicating long groundwater flow paths. Based on all the data collected and analyzed, two parametric methods were applied: 1) the Dematteis method, slightly adapted to the case study and the available data, which allows assessment of both potential inflows within the tunnel and potential impacts on springs (codified as the drawdown hazard index; DHI); 2) the Cesano method, which only allow assessment of potential inflows within the tunnel, thereby discriminating between major and minor inflows. Contemporarily, a groundwater flow model was implemented with the equivalent porous medium (EPM) approach in MODFLOW-2000. This model was calibrated under steady-state conditions against the available data (groundwater levels inside wells/piezometers and elevation and flow rate of springs). The Dematteis method was demonstrated to be more reliable and suitable for the site than was the Cesano method. This method was validated considering a tunnel through gneissic rock masses, and this approach considered intrinsic parameters of rock masses more notably than morphological and geomorphological factors were considered. The Cesano method relatively overestimated tunnel inflows, considering variations in the topography and overburden above the tunnel. Sensitivity analysis revealed a low sensitivity of these parametric methods to parameter values, except for the rock quality designation (RQD) employed to represent the fracturing degree. The numerical model was calibrated under ante-operam conditions, and sensitivity analysis evaluated the influence of uncertainties in the hydraulic conductivity (K) values of the different hydrogeological units.The hydraulic head distribution after tunnel excavation was forecasted considering three scenarios, namely, a draining tunnel, tunnel as a eater loss source, and tunnel sealed along its aquifer sectors, considering 3 levels of K reduction. Tunnel impermeabilization was very effective, thus lowering the drainage rate and impact on springs. The model quantitatively defined tunnel inflows and the effects on spring flow at the surface in terms of flow rate decrease. The Dematteis method and numerical model were combined to obtain a final risk of impact on the springs. This study likely overestimated the risk because all the values assigned to the parameters were chosen in a conservative way, and the steady-state numerical simulations were also very conservative (the transient state in this hydrogeological setting supposedly lasts 1-3 years). Monitoring of the tunnel and springs during tunnel boring could facilitate the feedback process

Crystal experiments on efficient beam extraction

Silicon crystal was channeling and extracting 70-GeV protons from the U-70 accelerator with efficiency of 85.3+-2.8% as measured for a beam of 10^12 protons directed towards crystals of 2 mm length in spills of 1-2 s duration. The experimental data follow very well the prediction of Monte Carlo simulations. This success is important to devise a more efficient use of the U-70 accelerator in Protvino and provides a crucial support for implementation of crystal-assisted collimation of gold ion beam in RHIC and slow extraction from AGS onto E952, now in preparation at Brookhaven Nat'l Lab. Future applications, spanning in the energy from sub-GeV (medical) to order of 1 GeV (scraping in the SNS, extraction from COSY) to order of 1 TeV and beyond (scraping in the Tevatron, LHC, VLHC), can benefit from these studies.Comment: 12pp. Presented at 19-th Intern. Conference on Atomic Collisions in Solids (ICACS-19: Paris, July 29 - August 3, 2001

Progress in crystal extraction and collimation

Recent IHEP Protvino experiments show efficiencies of crystal-assisted slow extraction and collimation of 85.3+-2.8%, at the intensities of the channeled beam on the order of 10^12 proton per spill of 2 s duration. The obtained experimental data well follows the theory predictions. We compare the measurements against theory and outline the theoretical potential for further improvement in the efficiency of the technique. This success is important for the efficient use of IHEP accelerator and for implementation of crystal-assisted collimation at RHIC and slow extraction from AGS onto E952, now in preparation. Future applications, spanning in the energy from order of 1 GeV (scraping in SNS, slow extraction from COSY and medical accelerators) to order of 1 TeV and beyond (scraping in Tevatron, LHC, VLHC), can benefit from these studies.Comment: 7pp. Presented at HEACC 2001 (Tsukuba, March 25-30

The Investigations Of Beam Extraction And Collimation At U-70 Proton Synchrotron Of IHEP By Using Short Silicon Crystals

The new results of using short (2-4mm) bent crystals for extraction and collimation of proton beam at IHEP 70 Gev proton synchrotron are reported. A broad range of energies from 6 to 65 GeV has been studied in the same crystal collimation set-up. The efficiency of extraction more than 85% and intensity more than 10E12 were obtained by using crystal with the length 2-mm and the angle 1 mrad. The new regime of extraction is applied now at the accelerator to deliver the beam for different experimental setups within the range of intensity 10E7-10E12ppp.Comment: Presented at EPAC 2002 (Paris, June 3-7), 3p

Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma?

Background: The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk, nonbrisk, and absent. Several studies have shown that a greater presence of TILs, especially brisk, in primary melanoma is associated with a better prognosis and higher survival rate. Patients and Methods: We investigated by enzyme-linked immunosorbent assay (ELISA) the correlation between PD-1 levels in plasma and the presence/absence of TILs in 28 patients with metastatic melanoma. Results: Low plasma PD-1 levels were correlated with brisk TILs in primary melanoma, whereas intermediate values correlated with the nonbrisk TILs, and high PD-1 levels with absent TILs. Although the low number of samples did not allow us to obtain a statistically significant correlation between the plasma PD-1 levels and the patients' overall survival depending on the absence/presence of TILs, the median survival of patients having brisk type TILs was 5 months higher than that of patients with absent and nonbrisk TILs. Conclusions: This work highlights the ability of measuring the plasma PD-1 levels in order to predict the prognosis of patients with untreated metastatic melanoma without a BRAF mutation at the time of diagnosis

Crystal Undulator As A Novel Compact Source Of Radiation

A crystalline undulator (CU) with periodically deformed crystallographic planes is capable of deflecting charged particles with the same strength as an equivalent magnetic field of 1000 T and could provide quite a short period L in the sub-millimeter range. We present an idea for creation of a CU and report its first realization. One face of a silicon crystal was given periodic micro-scratches (grooves), with a period of 1 mm, by means of a diamond blade. The X-ray tests of the crystal deformation have shown that a sinusoidal-like shape of crystalline planes goes through the bulk of the crystal. This opens up the possibility for experiments with high-energy particles channeled in CU, a novel compact source of radiation. The first experiment on photon emission in CU has been started at LNF with 800 MeV positrons aiming to produce 50 keV undulator photons.Comment: Presented at PAC 2003 (Portland, May 12-16

Groundwater processes in a complex landslide, northern Apennines, Italy

The hydrogeological characteristics of rototranslationalslides in flysch are complex, due to the inherentanisotropy and heterogeneity of rock masses and related deposits.The paper deals with the hydrogeological characterizationof a reactivated roto-translational slide affecting Cretaceousflysch rocks, located in the northern Apennines ofItaly. Continuous monitoring of groundwater levels, in-situpermeability and pumping tests, hydrochemical and physicalanalyses and Uranine tracers were the adopted prospectingmethods.In this research hydrological monitoring and investigationare summarized in order to define a hydrogeological conceptualmodel of the landslide source area. Results showed thattwo overlaying hydrogeological units exist at the slope scale:the first is unconfined, but highly compartmentalized, andhosted in the fractured and dismembered rock slide body.The second is confined and lays in the undisturbed flyschbelow the sliding surface. The groundwater level in theconfined hydrogeological unit is twenty meters higher thanthe groundwater level in the uppermost one. Moreover, thegroundwater chemistry characterization revealed a rising ofdeep fluids in the landslide area

A successful defence strategy in grapevine cultivar ‘Tocai friulano’ provides compartmentation of grapevine Flavescence dorée phytoplasma

Background: Flavescence dorée (FD) is a grapevine disease caused by phytoplasma and it is one of the most destructive pathologies in Europe. Nowadays, the only strategies used to control the epidemics are insecticides against vector, but more sustainable techniques are required. Completely resistant Vitis vinifera varieties have not been uncovered yet, but differences in susceptibility among cultivars and spontaneous recovery from FD symptoms have been observed. The grapevine cultivar ‘Tocai friulano’ shows very low susceptibility to FD but its defence strategy to counteract the phytoplasma spread has not been deciphered yet. In this work, the mechanisms occurring within ‘Tocai friulano’ FD-infected plants were examined in depth to identify the phytoplasma distribution and the defence pathways involved. Results: In ‘Tocai friulano’ symptoms of FD-infection remained confined near the area where they appeared during all the vegetative season. Analyses of secondary phloem showed a total absence of FD phytoplasma (FDp) in the trunk and its disappearance in 2-year-old arms from July to November, which was different from ‘Pinot gris’, a highly susceptible variety. Diverse modulations of defence genes and accumulation of metabolites were revealed in 1-year-old canes of ‘Tocai friulano’ FD-infected plants, depending on the sanitary status. Symptomatic portions showed high activation of both jasmonate- and salicylate-mediated responses, together with a great accumulation of resveratrol. Whereas activation of jasmonate-mediated response and high content of ε-viniferin were identified in asymptomatic 1-year-old cane portions close to the symptomatic ones. Conclusion: Successful defence mechanisms activated near the symptomatic areas allowed the compartmentation of FD symptoms and phytoplasmas within the infected ‘Tocai friulano’ plants. These results could suggest specific agronomical practices to be adopted during FD management of this variety, and drive research of resistance genes against FD

Crystal Deflector for Highly-efficient Channelling Extraction of a Proton Beam from Accelerators

The design and manufacturing details of a new crystal deflector for proton beams are reported. The technique allows one to manufacture a very short deflector along the beam direction (2 mm). Thanks to that, multiple encounters of circulating particles with the crystal are possible with a reduced probability of multiple scattering and nuclear interactions per encounter. Thus, drastic increase in efficiency for particle extraction out of the accelerator was attained (85%) on a 70-GeV proton beam. We show the characteristics of the crystal-deflector and the technology behind it

Highly efficient crystal deflector for channeling extraction of a proton beam from accelerators

The design and performance of a novel crystal deflector for proton beams are reported. A silicon crystal was used to channel and extract 70 GeV protons from the U-70 accelerator in Protvino with an efficiency of 85%, as measured for a beam of ~1e12 protons directed towards crystals of ~2 mm length in spills of ~2 s duration. Experimental data agree with the theoretically predicted Monte Carlo results for channeling. The technique allows one to manufacture a very short deflector along the beam direction (2 mm). Consequently, multiple encounters of circulating particles with the crystal are possible with little probability of multiple scattering and nuclear interactions per encounter. Thus, drastic increase in efficiency for particle extraction out of the accelerator was attained. We show the characteristics of the crystal- deflector and the technology behind it. Such an achievement is important in devising a more efficient use of the U-70 accelerator and provides crucial support for implementing crystal-assisted slow extraction and collimation in other machines, such as the Tevatron, RHIC, the AGS, the SNS, COSY, and the LHC.Comment: Presented at PAC 2003 (Portland, May 12-16