452 research outputs found
Binning is Sinning: Redemption for Hubble Diagram using Photometrically Classified Type Ia Supernovae
Bayesian Estimation Applied to Multiple Species (BEAMS) has been implemented
in the BEAMS with Bias Corrections (BBC) framework to produce a redshift-binned
Hubble diagram (HD) for Type Ia Supernovae (SN Ia). The BBC method corrects for
selection effects and non-SNIa contamination, and systematic uncertainties are
described by a covariance matrix with dimension matching the number of BBC
redshift bins. For spectroscopically confirmed SNIa samples, a recent "Binning
is Sinning" article (BHS21, arxiv:2012.05900) showed that an unbinned HD and
covariance matrix reduces the systematic uncertainty by a factor of 1.5
compared to the binned approach. Here we extend their analysis to obtain an
unbinned HD for a photometrically identified sample processed with BBC. To test
this new method, we simulate and analyze 50 samples corresponding to the Dark
Energy Survey (DES) with a low-redshift anchor; the simulation includes SNe Ia,
and contaminants from core collapse SNe and peculiar SNe Ia. The analysis
includes systematic uncertainties for calibration, and measures the dark energy
equation of state parameter (w). Compared to a redshift-binned HD, the unbinned
HD with nearly 2,000 events results in a smaller systematic uncertainty, in
qualitative agreement with BHS21, and averaging results among the 50 samples we
find no evidence for bias in measured cosmological parameters. To reduce
computation time for fitting an unbinned HD with large samples, we propose an
HD-rebinning method that defines the HD in bins of redshift, color, and
stretch; the rebinned HD results in similar uncertainty as the unbinned case,
and shows no evidence for biased cosmology parameters
Study of the performance of standard RPC chambers as a function of bakelite temperature
A systematic study of the performance of the Resistive Plate Chambers as a function of the bakelite temperature is presented. The current, the rate and the efficiency were measured in the temperature range 22-40degreesC. The values of the relative humidity during the data taking were in the range 40-60%. Measurements show a strong dependence of the efficiency on bakelite temperature. (C) 2003 Elsevier Science B.V. All rights reserved
ST 1535: a preferential A2A adenosine receptor antagonist.
Antagonism of the A2A adenosine function has proved beneficial in the treatment of Parkinson's disease, in that it increases L-dopa therapeutical effects without concomitant worsening of its side-effects. In this paper we describe a preferential A2A adenosine antagonist, ST 1535, with long-lasting pharmacodynamic effects. It competitively antagonizes the effects of the A2A adenosine agonist NECA on cAMP in cells cloned with the human A2A adenosine receptor (IC50=353+/-30 nM), and the effects of the A1 adenosine agonist CHA on cAMP in cells cloned with the human A1 adenosine receptor (IC50=510+/-38 nM). ST 1535, at oral doses of 5 and 10 mg/kg, antagonizes catalepsy induced by intracerebroventricular administration of the A2A adenosine agonist CGS 21680 (10 microg/5 microl) in mice. At oral doses ranging between 5 and 20 mg/kg, ST 1535 induces hypermotility and antagonizes haloperidol-induced catalepsy in mice up to 7 h. Oral ST 1535, at 1.25 and 2.5 mg/kg, potentiates L-dopa effects in reducing haloperidol-induced catalepsy. ST 1535 represents a potential new compound, with long-lasting activity, for the treatment of Parkinson's disease
REGISTRI: Regorafenib in first-line of KIT/PDGFRA wild type metastatic GIST: a collaborative Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial
Wild type GIST; Biomarker; Clinical trialGIST de tipo salvaje; Biomarcador; Ensayo clÃnicoGIST de tipus salvatge, Biomarcador; Assaig clÃnicBackground
Approximately 15% of adult GIST patients harbor tumors that are wild-type for KIT and PDGFRα genes (KP-wtGIST). These tumors usually have SDH deficiencies, exhibit a more indolent behavior and are resistant to imatinib. Underlying oncogenic mechanisms in KP-wtGIST include overexpression of HIF1α high IGFR signaling through the MAPK pathway or BRAF activating mutation, among others. As regorafenib inhibits these signaling pathways, it was hypothesized that it could be more active as upfront therapy in advanced KP-wtGIST.
Methods
Adult patients with advanced KP-wtGIST after central confirmation by NGS, naïve of systemic treatment for advanced disease, were included in this international phase II trial. Eligible patients received regorafenib 160 mg per day for 21 days every 28 days. The primary endpoint was disease control rate (DCR), according to RECIST 1.1 at 12 weeks by central radiological assessment.
Results
From May 2016 to October 2020, 30 patients were identified as KP-wtGIST by Sanger sequencing and 16 were confirmed by central molecular screening with NGS. Finally, 15 were enrolled and received regorafenib. The study was prematurely closed due to the low accrual worsened by COVID outbreak. The DCR at 12 weeks was 86.7% by central assessment. A subset of 60% experienced some tumor shrinkage, with partial responses and stabilization observed in 13% and 87% respectively, by central assessment. SDH-deficient GIST showed better clinical outcome than other KP-wtGIST.
Conclusions
Regorafenib activity in KP-wtGIST compares favorably with other tyrosine kinase inhibitors, especially in the SDH-deficient GIST subset and it should be taken into consideration as upfront therapy of advanced KP-wtGIST.GEIS, Bayer and SELNET. SELNET has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement Nº. 825806
Boletim de Preços dos Alimentos Orgânicos no Varejo de Florianópolis
Florianópolis, n. 1, ago. 2018. Analisa os preços dos alimentos orgânicos comercializados em Florianópolis em junho e julho de 2018
Are semi-terrestrial crabs threatened by human noise? Assessment of behavioural and biochemical responses of Neohelice granulata (Brachyura, Varunidae) in tank
This study examined the effects of human lab-generated noise (sweep tone) on the behaviour and biochemistry of a semi-terrestrial crab (Neohelice granulata). The experiment was carried out in tanks equipped with video- and audio-recording systems on a total of seventy-eight specimens. In total, 42 experimental trials with sweep-tone exposure and control conditions were performed using crabs in single and group layouts. After a habituation period of 30 min, the locomotor and acoustic (sound signals emitted by the crabs) behaviours were monitored for 30 min. During this time, the animals in sweep-tone conditions were exposed to ascending sweeps in a bandwidth range of 2.5–25 kHz. Exposure to sweep-tone noise produced significant changes in the number of signals emitted, locomotor behaviours and plasma parameters, such as haemolymph total haemocyte count and glucose, lactate and total protein concentrations, revealing that human noise could represent a disturbance for this crustacean species.Fil: Filiciotto, Francesco. National Research Council - Institute for Coastal Marine Environment,Mesina; ItaliaFil: Sal Moyano, MarÃa Paz. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: de Vincenzi, Giovanni. National Research Council - Institute for Coastal Marine Environment, Messina; ItaliaFil: Hidalgo, Fernando Jose. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Sciacca, Virginia. National Research Council - Institute for Coastal Marine Environment, Messina; ItaliaFil: Bazterrica, Maria Cielo. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Corrias, Valentina. National Research Council - Institute for Coastal Marine Environment, Messina; ItaliaFil: Lorusso, MartÃn. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; ArgentinaFil: Mazzola, Salvatore. National Research Council - Institute for Coastal Marine Environment; ItaliaFil: Buscaino, Giuseppa. National Research Council - Institute for Coastal Marine Environment; ItaliaFil: Gavio, Maria Andrea. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Centro CientÃfico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Marinas y Costeras. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Marinas y Costeras; Argentin
GPR and seismic surveying in the World War I scenario of Punta Linke (Ortles-Cevedale Group, Italian Alps).
The Ortles-Cevedale Group was the setting of repeated clashes occurring under extreme conditions and at the highest altitudes of all fightings in the Great War (WWI). The research scenario associated with the group is very challenging because modern research faces a series of logistical and climatic obstacles. The gradual retreat of glaciers has unearthed several archaeological remains of WWI such as barracks, barbed wire, military ammunition, weapons and other materials. The study site is the saddle between M. Vioz and Punta Linke, where the Historic War Museum of Pejo, under the direction of the Archaeological Service of the Province of Trento (Soprintendenza per i Beni Culturali, Ufficio Beni Archeologici), started an archaeological excavation in the year 2009 of some of the infrastructure of the cableway station, which also includes a tunnel section in the bedrock.
The saddle is placed at the head of Forni Glacier. GPR and seismic imaging was the best survey choice to characterize the glaciological and geo-archaeological context and to find structures or remains within the ice mass. Geophysical imaging spanned two campaigns in the years 2010 and 2011. The ice-rock interface was reconstructed in detail to depths greater than 45-50 m. The surface of the bedrock reveals a complex morphology, with several undulations and two rocky ridges elongated in the NNW-SSE direction. They identified some anomalous reflectors within the ice mass located near the western edge of the saddle of Punta Linke. The interpretation of radar profiles seems to indicate the presence of a tunnel in the ice, whose geometry and position is similar to others excavated in alpine glaciers during the Great War
Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer: a CellSearch analysis
Background: Circulating tumor cells (CTCs) provide prognostic information in patients with metastatic tumors.
Recent studies have shown that CTCs are released in circulation in an early phase of cancer disease so that their
presence is under investigation in the adjuvant setting. Few studies investigated the prognostic significance of CTCs
enumeration in patients with metastatic and advanced bladder cancer. The current study has analyzed the presence
of CTC in patients with nonmuscle-invasive bladder cancer (NMIBC).
Patients and methods: Forty-four NMIBC patients were enrolled and included in a 24-month follow-up program.
Blood drawings were carried out in all patients at the first diagnosis. CellSearch system (Veridex; LLC, Raritan, NJ) was
used for CTCs enumeration.
Results: CTC were detectable in 8/44 patients (18%). Presence of CTC was found significantly associated to shorter
time to first recurrence (6.5 versus 21.7 months, P < 0.001). Median time to progression was not reached, due to the
short follow-up period. CTC presence was found associated to concomitant carcinoma in situ and higher T category.
Conclusion: The detection of CTC in this setting of disease may allow to distinguish patients with high risk of
recurrence from those with high risk of progression, as well as to early identify patients candidate for adjuvant
treatment
Amalgame: Cosmological Constraints from the First Combined Photometric Supernova Sample
Future constraints of cosmological parameters from Type Ia supernovae (SNe
Ia) will depend on the use of photometric samples, those samples without
spectroscopic measurements of the SNe Ia. There is a growing number of analyses
that show that photometric samples can be utilised for precision cosmological
studies with minimal systematic uncertainties. To investigate this claim, we
perform the first analysis that combines two separate photometric samples, SDSS
and Pan-STARRS, without including a low-redshift anchor. We evaluate the
consistency of the cosmological parameters from these two samples and find they
are consistent with each other to under . From the combined sample,
named Amalgame, we measure with SN alone in a flat
CDM model, and and when combining with a Planck data prior and a flat
CDM model. These results are consistent with constraints from the Pantheon+
analysis of only spectroscopically confirmed SNe Ia, and show that there are no
significant impediments to analyses of purely photometric samples of SNe Ia.Comment: Submitting to MNRAS; comments welcom
Neural correlates of anosognosia in Alzheimer\u2019s disease and mild cognitive impairment: A multi-method assessment
Patients with Alzheimer\u2019s Disease (AD) and Mild Cognitive Impairment (MCI) may present anosognosia for their cognitive deficits. Three different methods have been usually used to measure anosognosia in patients with AD and MCI, but no studies have established if they share similar neuroanatomical correlates. The purpose of this study was to investigate if anosognosia scores obtained with the three most commonly used methods to assess anosognosia relate to focal atrophy in AD and MCI patients, in order to improve understanding of the neural basis of anosognosia in dementia. Anosognosia was evaluated in 27 patients (15 MCI and 12 AD) through clinical rating (Clinical Insight Rating Scale, CIRS), patient-informant discrepancy (Anosognosia Questionnaire Dementia, AQ-D), and performance discrepancy on different cognitive domains (self-appraisal discrepancies, SADs). Voxel-based morphometry correlational analyses were performed on magnetic resonance imaging (MRI) data with each anosognosia score. Increasing anosognosia on any anosognosia measurement (CIRS, AQ-D, SADs) was associated with increasing gray matter atrophy in the medial temporal lobe including the right hippocampus. Our results support a unitary mechanism of anosognosia in AD and MCI, in which medial temporal lobes play a key role, irrespectively of the assessment method used. This is in accordance with models suggesting that anosognosia in AD is primarily caused by a decline in mnemonic processes
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