Synthesis and stability evaluation of novel peptidomimetic Caspase-1 inhibitors for topical application

International audienceDuring our search for topically-active Caspase-1 inhibitors, we identified a novel class of potent in-hibitors based on a 1,3,5-trisubstituted uracil motif equipped with an L-aspartate semi-aldehyde derived warhead. In the literature, the majority of Caspase-1 inhibitors possessing the same warhead have been designed and evaluated for oral administration as the ethyl acetal pro-drug form. For our topical program , the pro-drug acetal form was not fully hydrolysed in the skin and was unstable in many of our standard topical excipients, therefore, we were obliged to focus on the actual hemiacetal drug form of the molecule during our drug discovery program. Our work focuses on both the synthesis and achiral and chiral stability of the final drug molecules in topical excipients

Le rôle du C.L.A.N. (Comité de liaison alimentation-nutrition) en milieu hospitalier

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

Rinçage des cathéters périphériques (l'héparine est-elle nécessaire?)

MONTPELLIER-BU Pharmacie (341722105) / SudocSudocFranceF

CARACTÉRISATION ET PROPRIÉTÉS DES FIBRES DE CARBONE REVÊTUES DE CARBURES RÉFRACTAIRES DÉPOSÉS PAR CVD RÉACTIVE

The reactive chemical vapour deposition (RCVD) process is based on the reactivity of a substrate and a vapour phase. It is used for the coating of T300 carbon fibers. The conditions of SiC, TiC and B4C deposits are discussed with the aid of thermodynamical calculations and experimental results. The diagrams of solid phases existences in the SiCl4-H2-C, TiCl4-H2-C and BCl3-H2-C systems are established with the goal to determine the experimental conditions (temperature, initial gas composition) avoiding the possibility of Si(s), Ti(s) or B(s) formation. These results are optimized on the carbon fibers in the reactor at T > 1300K. It is shown that this treatment allows, under some conditions, the elaboration of thin uniform coating of carbide, even inside the yarn constituted of 6000 filaments. The mechanical characteristics of the fibers evaluated by tensile tests on monofilaments and the barrier effects of the carbides towards the oxydation are given as a function of the thickness of the deposit.Le procédé de RCVD qui repose sur la réactivité du substrat et d'une phase gazeuse a été appliquée au revêtement des fibres de carbone T300. Les conditions de dépôt de SiC, TiC et B4C sont discutées avec l'aide de calcul thermodynamique et de résultats expérimentaux. Les diagrammes d'existences de phases solides dans les systèmes SiCl4-H2-C, TiCl4-H2-C et BCl3-H2-C ont été établis dans le but de déterminer les conditions (température, composition de la phase gazeuse initiale) excluant la formation de Si(S), Ti(s) ou de B(s). Ces résultats ont été optimisés sur les fibres de carbone traitées en continu dans un réacteur à T > 1300 K. Il est montré que le traitement permet, sous certaines conditions, l'élaboration d'une fine couche de carbure uniforme même au sein de la mèche constituée de 6000 filaments unitaires. Les caractéristiques mécaniques des fibres évaluées par des tests de traction sur monofilaments et le rôle protecteur du carbure vis-à-vis de l'oxydation sont donnés en fonction de l'épaisseur du carbure

Processing of (PyC/TiC) n multilayered coatings by pulsed CVD and RCVD

International audiencePyrocarbon/titanium carbide (PyC/TiC) n multilayered coatings have been deposited on carbon substrates by P-RCVD which is a combination of pulsed chemical vapour deposition (P-CVD) with reactive CVD (RCVD). From thermodynamic calculations, a thin TiC sublayer deposited between two PyC sublayers should be stoichiometric. TiC and PyC growth rates have been investigated, as well as PyC consumption occurring during carbide growth by P-RCVD. Hence, this process allows to achieve a sharp control of each sublayer thickness. Furthermore, it seems possible to totally consume the PyC intercalated between adjacent carbide sublayers in order to obtain a multilayered carbide (TiC) n. This method has been achieved to carbon fibre coating. The very first mechanical tests carried out on coated fibres are encouraging. The next step of this work lies in the study of such sub-micrometric coatings as interphases in ceramic matrix composites

SiC/SiC minicomposites with structure-graded BN interphases

International audienc

Interface Tailoring in Carbon Fibres Reinforced Metal Matrix Composites

The fabrication of high performance metal matrix composites requires the optimization of the interfacial bonding, which supposes a strict control of the reactivity and of the wettability between the matrix and the reinforcement, specially for materials produced by casting techniques. In this scope, two methods are described consisting on the one hand, in the surface treatment of carbon fibres by a particular type of CVD and, on the other hand, in modifying the composition of the matrix. The two methods can be used either separately or in combination, sucessful tailoring of the interface being the result of thermodynamic or kinetic effects