3D-Printed Hand Controlled by Arm Gestures to Verify the Robustness and Reliability of a Low Cost Surface Electromyography System

The study focuses on the development of a low-cost surface electromyography and 3D-printed hand gesture-recognition system. The complete system captures four (4) channels of EMG data through sEMG amplifier circuits interfaced to an Arduino prototyping board. This data is sent to a workstation wherein the graphical user interface shows the pre-processed signal. The gestures are used as control for the movements of the 3D-printed arm

The Relationship of Corporate Financial Performance and Innovation among Manufacturing Industries

Innovation is becoming a critical determinant of the survival and advancement of firms. Despite this realization, there is a dearth of literature that tackles the subject matter and its specific role in corporate settings remains vague. Using corporate data on East and Southeast Asian manufacturing firms from 2008 to 2013, this study aims to identify the impact of corporate financial performance on research and development (R&D) expenditure as a measure of innovation. On the whole, the researchers utilized random effects (REM) and fixed effects (FEM) models to establish the relationship between R&D and corporate performance. The researchers, then, identified the factors that affected R&D. The researchers found that sales, profitability, and cash flow have positive relationships with R&D. Moreover, when firm size is considered, the researchers discovered that R&D determinants for large manufacturing firms were different - total profitability and liabilities and debt - from those of SMEs - number of employees and sales for SMEs

Cognitive Aging

The study of cognitive function in gerontology is considered relevant because it is an important risk factor for other pathologies in the old age, such as physical disability and dependence, depression, and frailty, mainly because of early pathological changes in cognitive function which are considered a preclinical state that may progress to dementia. In this chapter, cognitive functioning and the dimensions that are included in it (attention, memory, meta-memory, processing speed, executive functions, visuospatial skills, and language) are conceptualized. Additionally, the current evidence is analyzed regarding age-associated changes that are experienced during cognitive aging. These changes, or cognitive decline, are distinguished from those that are part of cognitive pathologies, the most common mild cognitive impairment and dementia. Such pathologies are conceptualized based on the current diagnostic criteria, and controversies and challenges are discussed. Additionally, we analyze the risk factors for cognitive functioning in aging, both modifiable and nonmodifiable ones. A review of the main nonpharmacological intervention techniques used from the gerontology approach is made. It includes the cognitive training in the case of age-related decline or techniques of stimulation and cognitive rehabilitation in the case of mild cognitive impairment or dementia. Finally, we conclude with an analysis of the current state of this topic in the field of gerontology and its relevance in professional practice

Las concepciones epistemológicas de un profesor investigador en Historia: El constructivismo como postura epistemológica

Este artí­culo tiene como objetivo indagar las concepciones epistemológicas de un profesor investigador en historia de un instituto de investigación de una universidad pública mexicana, debido a que una de las metas de esta institución es formar recursos humanos competentes para realizar investigación histórica, capaces de utilizar las herramientas teórico-metodológicas para el estudio de procesos locales, regionales e internacionales. De tal forma que es importante conocer estas concepciones porque ello incidirá en la imagen futura de los estudiantes de posgrado y futuros investigadores sobre investigación en esta disciplina y no sabemos si la que se está socializando es la más adecuada. El método cualitativo es la investigación narrativa auxiliado de la entrevista a profundidad. Los resultados arrojaron   diez categorí­as que describen las concepciones epistemológicas que conforman su práctica investigativa: Orí­genes e influencias en la formación epistemológica, formación y desarrollo profesional, práctica investigativa y polí­ticas institucionales, posición epistemológica, concepción del pasado, la observación en la historia, interpretación de las fuentes, la historia y otras disciplinas y la historia y los conceptos.   Por último, concluimos que el profesor-investigador se concibe como constructivista, dando prioridad a la observación y a la historicidad de los conceptos, posición que le otorga seguridad y claridad paradigmática en su investigación empí­rica, pero que lamentablemente se descuida la investigación y creación teórica. Por último, deducimos que estos factores repercutirán en una práctica docente e investigativa bajo los supuestos de este paradigma epistemológico

Comparison of inpatient vs. outpatient anterior cervical discectomy and fusion: a retrospective case series

<p>Abstract</p> <p>Background</p> <p>Spinal surgery is increasingly being done in the outpatient setting. We reviewed our experience with inpatient and outpatient single-level anterior cervical discectomy and fusion with plating (ACDF+P).</p> <p>Methods</p> <p>All patients undergoing single-level anterior cervical discectomy and fusion with plating between August 2005 and May 2007 by two surgeons (RPB or JAF) were retrospectively reviewed. All patients underwent anterior cervical microdiscectomy, arthrodesis using structural allograft, and titanium plating. A planned change from doing ACDF+P on an inpatient basis to doing ACDF+P on an outpatient basis was instituted at the midpoint of the study. There were no other changes in technique, patient selection, instrumentation, facility, or other factors. All procedures were done in full-service hospitals accommodating outpatient and inpatient care.</p> <p>Results</p> <p>64 patients underwent ACDF+P as inpatients, while 45 underwent ACDF+P as outpatients. When outpatient surgery was planned, 17 patients were treated as inpatients due to medical comorbidities (14), older age (1), and patient preference (2). At a mean follow-up of 62.4 days, 90 patients had an excellent outcome, 19 patients had a good outcome, and no patients had a fair or poor outcome. There was no significant difference in outcome between inpatients and outpatients. There were 4 complications, all occurring in inpatients: a hematoma one week post-operatively requiring drainage, a cerebrospinal fluid leak treated with lumbar drainage, syncope of unknown etiology, and moderate dysphagia.</p> <p>Conclusion</p> <p>In this series, outpatient ACDF+P was safe and was not associated with a significant difference in outcome compared with inpatient ACDF+P.</p

Initial clinical experience with frameless optically guided stereotactic radiosurgery/radiotherapy in pediatric patients

The objective of this study is to report our initial experience treating pediatric patients with central nervous system tumors using a frameless, optically guided linear accelerator. Pediatric patients were selected for treatment after evaluation by a multidisciplinary neuro-oncology team including neurosurgery, neurology, pathology, oncology, and radiation oncology. Prior to treatment, all patients underwent treatment planning using magnetic resonance imaging (MRI) and treatment simulation on a standard computed tomography scanner (CT). For CT simulation, patients were fitted with a customized plastic face mask with a bite block attached to an optical array with four reflective markers. After ensuring adequate reproducibility, these markers were tracked during treatment by an infra-red camera. All treatments were delivered on a Varian Trilogy linear accelerator. The follow-up period ranges from 1–18 months, with a median follow-up of 6 months. Nine patients, ages ranging from 12 to 19 years old (median age 15 years old), with a variety of tumors have been treated. Patients were treated for juvenile pilocytic astrocytoma (JPA; n = 2), pontine low-grade astrocytoma (n = 1), pituitary adenoma (n = 3), metastatic medulloblastoma (n = 1), acoustic neuroma (n = 1), and pineocytoma (n = 1). We followed patients for a median of 12 months (range 3–18 months) with no in-field failures and were able to obtain encouraging toxicity profiles. Frameless stereotactic optically guided radiosurgery and radiotherapy provides a feasible and accurate tool to treat a number of benign and malignant tumors in children with minimal treatment-related morbidity

Evidence for maintenance of sex determinants but not of sexual stages in red yeasts, a group of early diverged basidiomycetes

<p>Abstract</p> <p>Background</p> <p>The red yeasts are an early diverged group of basidiomycetes comprising sexual and asexual species. Sexuality is based on two compatible mating types and sexual identity is determined by <it>MAT </it>loci that encode homeodomain transcription factors, peptide pheromones and their receptors. The objective of the present study was to investigate the presence and integrity of <it>MAT </it>genes throughout the phylogenetic diversity of red yeasts belonging to the order Sporidiobolales.</p> <p>Results</p> <p>We surveyed 18 sexual heterothallic and self-fertile species and 16 asexual species. Functional pheromone receptor homologues (<it>STE3.A1 </it>and <it>STE3.A2</it>) were found in multiple isolates of most of the sexual and asexual species. For each of the two mating types, sequence comparisons with whole-genome data indicated that synteny tended to be conserved along the pheromone receptor region. For the homeodomain transcription factor, likelihood methods suggested that diversifying selection acting on the self/non-self recognition region promotes diversity in sexual species, while rapid evolution seems to be due to relaxed selection in asexual strains.</p> <p>Conclusions</p> <p>The majority of both sexual and asexual species of red yeasts have functional pheromone receptors and homeodomain homologues. This and the frequent existence of asexual strains within sexual species, makes the separation between sexual and asexual species imprecise. Events of loss of sexuality seem to be recent and frequent, but not uniformly distributed within the Sporidiobolales. Loss of sex could promote speciation by fostering the emergence of asexual lineages from an ancestral sexual stock, but does not seem to contribute to the generation of exclusively asexual lineages that persist for a long time.</p

Inhibition of the Nuclear Import of Cubitus Interruptus by Roadkill in the Presence of Strong Hedgehog Signal

Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors. In the process of proper pattern formation, Ci activity is regulated by multiple mechanisms, including processing, trafficking, and degradation. However, it remains elusive how Ci distinctly recognizes the strong and moderate Hh signals. Roadkill (Rdx) induces Ci degradation in the anterior region of the Drosophila wing disc. Here, we report that Rdx inhibited Ci activity by two different mechanisms. In the region abutting the anterior/posterior boundary, which receives strong Hh signal, Rdx inhibited the nuclear import of Ci by releasing importin α3 from Ci. In this region, Rdx negatively regulated the expression of transcription factor Knot/Collier. In farther anterior regions receiving moderate levels of Hh signal, Rdx induced Ci degradation, as reported previously. Thus, two different mechanisms by which Rdx negatively regulates Ci may play an important role in the fine-tuning of Hh responses