Introducing dynamism in emotional agent societies

[EN] This paper presents the development of a dynamic emotional model to be employed in agent societies. The proposed model is based on the PAD emotional model and allows the representation of the emotional contagion phenomena of a heterogeneous group of agents that are capable of express emotions. The model is mainly based on three elements: personality, empathy and affinity. These elements allow the characterisation of each individual, causing them susceptible to vary in some degree the emotions of other individuals. Additionally, the model allows defining of the social emotion of this group of agents. (C) 2017 Elsevier B.V. All rights reserved.This work is partially supported by the MINECO/FEDER TIN2015-65515-C4-1-R and the FPI grant AP2013-01276 awarded to Jaime-Andres Rincon. This work is supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT - Fundacao para a Ciencia e Tecnologia within the projects UID/CEC/00319/2013 and Post-Doc scholarship SFRH/BPD/102696/2014 (A. Costa).Rincon, J.; Costa, A.; Villarrubia, G.; Julian Inglada, VJ.; Carrascosa Casamayor, C. (2018). Introducing dynamism in emotional agent societies. Neurocomputing. 272:27-39. https://doi.org/10.1016/j.neucom.2017.03.091S273927

AM3 (Inmunoferón®) as an adjuvant to hepatitis B vaccination in hemodialysis patients

AM3 (Inmunoferón®) as an adjuvant to hepatitis B vaccination in hemodialysis patients.BackgroundPatients with end-stage renal disease (ESRD) undergoing hemodialysis have severe alterations in cell-mediated immunity (CMI) that increases their risk of contracting chronic hepatitis B virus (HBV) infection and decreases their protective responses to HBV vaccine. In an effort to improve the humoral response to an accelerated HBV vaccine protocol in these patients, the ability of an immunomodulator, AM3, to improve seroconversion was investigated.MethodsA total of 269 patients were enrolled in a multicenter trial. All patients received a DNA recombinant vaccine (40 μg HBsAg/dose/day) on days 0, 10, 21, and 90. AM3 or placebo (3 g/day) was given orally for 30 consecutive days beginning 15 days prior to the first vaccine dose. Anti-HBsAg titers were measured on days 120 and 270 after the beginning of the trial.ResultsAfter one month, 207 patients could be evaluated and 132 patients after six months. The placebo and AM3-treated groups had comparable seroconversion and protective response rates one month after the final vaccine dose. The AM3 treatment group, but not the placebo group, maintained these protective titers up to six months after the final vaccine dose. At this time, the percentage of high responders (anti-HBsAg>100 IU/L) and mean anti-HBsAg titers in the AM3 group was significantly higher than in the placebo group.ConclusionsAM3 is a safe and easily tolerated oral agent that potentiates long-term serological immunity to hepatitis B in hemodialysis patients after vaccination