Dr Niels Conradt Haug 95

Eesti Arst 2017; 96(8):49

Mapping the lithoceramic claddings conservation status in a BIM environment

Italian Modern Movement architecture is characterized above all by the research and use of innovative, experimental and autarkic materials. Lithoceramics is one of the most interesting and widespread cladding materials and represents the Italian reinterpretation of klinker, a very popular ceramic material in Germany and in the Netherlands. Despite the excellent technical performances of the ceramic cladding, increasingly frequent detachment episodes make maintenance interventions necessary on this building stock. Starting from a brief illustration of the characteristics of lithoceramics and of the most significant applications, the paper intends to present a BIM-based digitization methodology for mapping the conservation status of this façade cladding technology, through exemplification on a significant case study. The BIM model contains all the information necessary for the mapping of the state of conservation, for the recovery and maintenance activities of the ceramic elements. The proposed methodology allows a faster and more efficient visualization of the present faults and proposes a targeted intervention system, in relation to the detected fault. This approach contributes to protecting the historical connotation of this building heritage, favoring restoration and cleaning, reducing the time and, consequently, costs of maintenance

Chapter La basilica inferiore di San Crisogono: lettura morfometrica di un’architettura stratificata

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences

The European Research Infrastructures of the ESFRI Roadmap in Biological and Medical Sciences: status and perspectives

Introduction. Since 2002, the European Strategy Forum on Research Infrastructures  identified  the  needs  for  Research  Infrastructures  (RIs)  in  Europe  in  priority  fields  of  scientific research and drafted a strategic document, the ESFRI Roadmap, defining the  specific RIs essential to foster European research and economy. The Biological and Medical Sciences RIs (BMS RIs) were developed thanks to the active participation of many  institutions  in  different  European  member  states  associated  to  address  the  emerging  needs in biomedicine and, among these, the Italian National Institute of Health (ISS),  in virtue of its role in public health and research, has been specifically involved in the  national development and implementation of three RIs: the Biobanking and Biomolecu-lar Resources Research Infrastructure (BBMRI), the European Advanced Translational  Research Infrastructure in Medicine (EATRIS) and the European Clinical Research Infrastructures Network (ECRIN). Aim.  This  article  outlines  the  design  and  development  of  these  RIs  up  to  the  recent  achievement of the ERIC status, their importance in the Horizon 2020 programme and  their societal and economic potential impact, with special attention to their development  and significance in Italy. Conclusions.  The  ISS  plays  a  unique  role  in  fostering  a  coordinated  participation  of  excellence Italian institutes/facilities to different European biomedical RIs, thus contributing to health innovation, healthcare optimization, and healthcare cost containment.

Unagreement is an illusion

This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s11049-015-9311-yThis paper proposes an analysis of unagreement, a phenomenon involving an apparent mismatch between a definite third person plural subject and first or second person plural subject agreement observed in various null subject languages (e.g. Spanish, Modern Greek and Bulgarian), but notoriously absent in others (e.g. Italian, European Portuguese). A cross-linguistic correlation between unagreement and the structure of adnominal pronoun constructions suggests that the availability of unagreement depends on whether person and definiteness are hosted by separate heads (in languages like Greek) or bundled on a single head (i.e. pronominal determiners in languages like Italian). Null spell-out of the head hosting person features high in the extended nominal projection of the subject leads to unagreement. The lack of unagreement in languages with pronominal determiners results from the interaction of their syntactic structure with the properties of the vocabulary items realising the head encoding both person and definiteness. The analysis provides a principled explanation for the cross-linguistic distribution of unagreement and suggests a unified framework for deriving unagreement, adnominal pronoun constructions, personal pronouns and pro

The Diamond - Sheffield, UK

L'articolo presenta il caso studio del nuovo edificio della Facoltà di Ingegneria dell'università inglese di Sheffield, noto come "The Diamond" per il suo singolare involucro, con particolare attenzione al ruolo giocato dalla progettazione in ambiente BIM

Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation

Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed that the number of children treated with SGA indication is still small (prevalence 0.37/100,000) and these children are significantly less reported than those treated for growth hormone deficiency (GHD), although GHD prevalence is 1:4000-1:10,000. This means that many short children born SGA are still not properly identified, and therefore not treated with rhGH, or misdiagnosed as GHD. This article provides some practical tools for the identification of children eligible for rhGH treatment

La basilica inferiore di San Crisogono: lettura morfometrica di un’architettura stratificata San Crisogono’s Basilica: a morphometric reading of layered architecture

Il contributo intende investigare le potenzialità dei modelli numerici 2D e 3D per la lettura dell’architettura archeologica. Tale obiettivo è declinato sul caso studio della Basilica inferiore di San Crisogono (Roma). Questo manufatto, ad oggi fortemente compromesso nella sua configurazione spaziale, è palinsesto dal punto di vista artistico, per la stratificazione di sequenze di pitture stilisticamente e cronologicamente distinte su di uno stesso supporto murario, e dal punto di vista archeologico e architettonico, per la forte contaminazione tra strutture originarie, interventi successivi, restauri e consolidamenti strutturali. Questa complessità del monumento richiede un approccio di analisi sistematico, in grado di definire i termini del problema per muoversi dal noto, le tracce esistenti, all’ignoto, la ricostruzione del passato. Questo percorso, con una vocazione interdisciplinare per prerogativa, ha come primo cruciale passaggio la restituzione morfometrica delle tracce esistenti per la loro corretta localizzazione nel contesto e funzionale alla loro lettura sincronica comparativa. La ricerca ancora in corso, di cui presentiamo i primi risultati, ha come obiettivo finale la ricomposizione architettonica ed artistica del manufatto nelle sue diverse fasi di trasformazione. Questo ambizioso obiettivo vede nell’utilizzo dei modelli digitali integrati un valido strumento di comprensione oltre che di rappresentazione del pensiero critico specialistico.The paper aims to investigate the potential of 2D and 3D numerical models for the studying of archaeological architecture. Such objective is applied on the case study of the Lower Basilica of San Crisogono (Rome). This artefact is currently strongly compromised in its spatial configuration, nevertheless it is a palimpsest from the artistic point of view, for the stratification of sequences of stylistically and chronologically distinct paintings on the same wall support, and from the archaeological and architectural point of view, for the strong contamination between original structures, subsequent interventions, restorations and structural consolidations. This monument’s complexity requires a systematic approach of analysis, able to define the terms of the problem in order to move from the known, the existing traces, to the unknown, the reconstruction of the past. This path, with an interdisciplinary vocation for prerogative, has as its first crucial step the morphometric representation of the existing traces for their correct location in the context and functional to their synchronic comparative reading. The research still in progress, of which we present the first results, has as its ultimate goal the architectural and artistic recomposition of the artifact in its various phases of transformation. This ambitious objective sees in the use of integrated digital models a valid instrument of comprehension as well as representation of critical specialist though

Primary Retinal Cultures as a Tool for Modeling Diabetic Retinopathy: An Overview

Experimental models of diabetic retinopathy (DR) have had a crucial role in the comprehension of the pathophysiology of the disease and the identification of new therapeutic strategies. Most of these studies have been conducted in vivo, in animal models. However, a significant contribution has also been provided by studies on retinal cultures, especially regarding the effects of the potentially toxic components of the diabetic milieu on retinal cell homeostasis, the characterization of the mechanisms on the basis of retinal damage, and the identification of potentially protective molecules. In this review, we highlight the contribution given by primary retinal cultures to the study of DR, focusing on early neuroglial impairment. We also speculate on possible themes into which studies based on retinal cell cultures could provide deeper insight