Combined effect of low-frequency high-intensity ultrasound and streptokinase on the efficiency of thrombi destruction

Results of numerous experimental studies indicate that low-intensity ultrasound (US) intensifies the drug induced fibrinolysis. However, exits opinion, what high-intensity ultrasound could be not recommending for use in combination with thrombolytic agents due to the transience of exposure of thrombus to ultrasound and relatively low speed of the enzymatic process. We also hypothesise that high-intensity low-frequency US can accelerate the drug induced fibrinolysis. During in vitro studies, we showed that the administration of streptokinase (SK) prevents the formation of particle conglomerates resulting due to destruction of fibrin clots by using low-frequency high-intensity US. In addition, it was established that in conditions of the combined effect of streptokinase and high-intensity US, the process of acoustic-mechanical destruction of thrombus is prevailing, and the fibrinolytic effect of streptokinase is generally witnessed after the termination of US and manifests itself in enzymatic lysis of both resultant particles and residual clot mass. In this study we verified the effect of low-frequency high-intensity ultrasound on the dynamics and efficiency of fibrinolysis induced by streptokinase on various structure thrombi model, characteristic features of the fibrin clot network structure occurring during the combined effect of ultrasound and streptokinase

Measurement of trajectories of piezoelectric actuators with laser

Various measurement techniques have been developed for analyzing performance of piezoelectric devices. Recently laser Doppler vibrometer (LDV) has become a widely applied instrument for vibration measurements both in scientific studies and industry. The most common type of LDV is a single-point vibrometer. In this article we propose a system consisting of the single-point LDV, beam deflector and mirrors, which enable automated 2D/3D trajectory or 2D vibration measurements, where a high number of target points can be measured with a very high spatial resolution. We used two test objects to demonstrate the performance of the system: piezo-actuator, which transforms vibrations to the rotational movement and a micrometric screw with piezo-adjustment

Piezoelectric actuator for high resolution linear displacement systems

This work presents a piezoelectric actuator which is designed to improve resolution for micrometer screws or motorized actuators such as actuators with stepper motors. Several modifications of piezoelectric actuator were implemented for closed-loop and open-loop applications. For closed-loop applications strain gages are used to obtain a feedback signal. As a result a resolution of displacement measurement up to 18 nm is achieve

Combined effect of low-frequency high-intensity ultrasound and streptokinase on the efficiency of thrombi destruction

Results of numerous experimental studies indicate that low-intensity ultrasound (US) intensifies the drug induced fibrinolysis. However, exits opinion, what high-intensity ultrasound could be not recommending for use in combination with thrombolytic agents due to the transience of exposure of thrombus to ultrasound and relatively low speed of the enzymatic process. We also hypothesise that high-intensity low-frequency US can accelerate the drug induced fibrinolysis. During in vitro studies, we showed that the administration of streptokinase (SK) prevents the formation of particle conglomerates resulting due to destruction of fibrin clots by using low-frequency high-intensity US. In addition, it was established that in conditions of the combined effect of streptokinase and high-intensity US, the process of acoustic-mechanical destruction of thrombus is prevailing, and the fibrinolytic effect of streptokinase is generally witnessed after the termination of US and manifests itself in enzymatic lysis of both resultant particles and residual clot mass. In this study we verified the effect of low-frequency high-intensity ultrasound on the dynamics and efficiency of fibrinolysis induced by streptokinase on various structure thrombi model, characteristic features of the fibrin clot network structure occurring during the combined effect of ultrasound and streptokinase

Combined effect of low-frequency high-intensity ultrasound and streptokinase on the efficiency of thrombi destruction

Results of numerous experimental studies indicate that low-intensity ultrasound (US) intensifies the drug induced fibrinolysis. However, exits opinion, what high-intensity ultrasound could be not recommending for use in combination with thrombolytic agents due to the transience of exposure of thrombus to ultrasound and relatively low speed of the enzymatic process. We also hypothesise that high-intensity low-frequency US can accelerate the drug induced fibrinolysis. During in vitro studies, we showed that the administration of streptokinase (SK) prevents the formation of particle conglomerates resulting due to destruction of fibrin clots by using low-frequency high-intensity US. In addition, it was established that in conditions of the combined effect of streptokinase and high-intensity US, the process of acoustic-mechanical destruction of thrombus is prevailing, and the fibrinolytic effect of streptokinase is generally witnessed after the termination of US and manifests itself in enzymatic lysis of both resultant particles and residual clot mass. In this study we verified the effect of low-frequency high-intensity ultrasound on the dynamics and efficiency of fibrinolysis induced by streptokinase on various structure thrombi model, characteristic features of the fibrin clot network structure occurring during the combined effect of ultrasound and streptokinase

Griovių remonto darbo projekto etalonas : melioracijos metodiniai nurodymai

Vytauto Didžiojo universitetasŽemės ūkio akademij

Badanie wpływu wodoru stosowanego w silnikach spalinowych na emisję spalin

This article deals with the possibility to use hydrogen in gasoline and diesel engines. Hydrogen production in a vehicle and hydrogen generators mounted in a vehicle are overviewed. Under operation of the hydrogen generator electrical current changes with temperature, to stabilize current the current pulse generator is used. Modifications of an intake manifold were made in order to supply hydrogen to an engine. For this purpose a special universal plate to evenly mix the hydrogen with fuel mix was made designed. The experimental and rig tests were performed. The rig tests were carried out at constant 2200 rpm. It was found that smokiness, in both cases decreases with an additional deployment of hydrogen. Other indicators of the exhaust gas using the hydrogen in case of the rig tests are worse. A possible cause of negative influence is an excessive amount of hydrogen, which releases at 25 A current.Przedstawiony artykuł dotyczy możliwości wykorzystania wodoru w silnikach benzynowych i wysokoprężnych. Omówiono wytwarzanie wodoru w pojeździe oraz w generatorach wodoru zamontowanych w pojeździe.W trakcie funkcjonowania generatorawodoru prąd elektryczny zmienia się wraz z temperaturą; w celu stabilizacji prądu stosuje się generator impulsów prądowych. Aby dostarczyć wodór do silnika dokonano modyfikacji kolektora dolotowego. Do tego celu zaprojektowano specjalną uniwersalną płytę do równomiernego mieszania wodoru z mieszanką paliwową.Przeprowadzono próby eksperymentalne i próby na stanowisku badawczym. Próby na stanowisku badawczym prowadzono przy stałej prędkości obrotowej 2200 rpm. Stwierdzono, że zadymienie w obu przypadkach zmniejsza się wraz z dodatkowym wykorzystaniem wodoru. Inne wskaźniki spalin przy wykorzystaniu wodoru w przypadku badań na stanowisku badawczym wypadają mniej korzystnie. Możliwą przyczyną tego negatywnego oddziaływania jest nadmierna ilość wodoru, który uwalnia się w obecności prądu o wartości 25 A