Synthesis, characterization and antimicrobial studies of novel quinazoline derivatives of sydnone

1462-14673-[2-Substituted-4-oxo-3,4-dihydroquinazolin-6-yl]sydnones 10a-i have been synthesized from 2-(acetylamino)benzoic acid 1 by conventional route. The newly synthesized compounds 10a-i have been characterized by IR, NMR spectroscopy as well as by elemental analysis. Compounds 10a-i have also been screened for their antimicrobial activity against four important species of bacteria. Some compounds are found active against these species. </span

Synthesis, anti-bacterial, and anti-fungal activity of sydnone-based aromatic compounds

93-102In order to investigate the biological importance of sydnone ring system, two new series viz. 4-(<i style="mso-bidi-font-style: normal">N-(4-(3-(substitutedphenyl)acryloyl) phenyl) sulfamoyl)-3-p-tolyl-sydnone <b style="mso-bidi-font-weight: normal">(Series-A) and 4-(N-(4-(5-(substitutedphenyl)isoxazol-3-yl)phenyl)4-sulfamoyl)-3-p-tolyl-sydnone <b style="mso-bidi-font-weight: normal">(Series-B) have been synthesized. They have been characterized by FT-IR, 1H and 13C NMR and elemental analysis. The final compounds have been screened for their antibacterial activity against S. aureus and S. pyogenes from a Gram positive group of bacteria and E.coli and P. aeruginosa from a Gram negative group of bacteria and antifungal activity against C. albicans, A. niger and <i style="mso-bidi-font-style: normal">A. clavatus. The compound YA9 shows excellent activity against all tested strains of bacteria, while compound YB6 exhibits good activity against Gram positive bacteria S. aureus and YB7 displays good activity against both Gram negative bacteria E.coli and P. aeruginosa. </span

Synthesis and Antimicrobial Activity of 2-Substituted-3-((3-(6-Nitrobenzo[<i>D</i>]thiazol-2-yl)-4-oxo-3,4-Dihydroquinazolin-2-yl)Methyl)-1,3,4-thiadiazol-3-ium-5-thiolate

<div><p> </p><p>A new series of 2-substituted-3-((3-(6-nitrobenzo[d]thiazol-2-yl)-4-oxo-3,4-dihydroquinazolin-2-yl)methyl)-1,3,4-thiadiazol-3-ium-5-thiolate <b>6(a–j)</b> was synthesized starting from anthranilic acid <b>1</b>. The structures of the newly synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR, mass spectra, and elemental analysis. The final compounds were tested for their antimicrobial activity against several microbes. </p><p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Phosphorus, Sulfur, and Silicon and the Related Elements</i> for the following free supplemental files: Additional text and tables.]</p></div