Epilepsi hos barn - hvordan går det?

Epilepsi hos barn er mer enn anfall, og ofte er det tilleggsvanskene som er mest belastende. Vi vil undersøke hvordan det går med barn som har epilepsi. Hvordan går det med anfallene? Hvordan klarer de seg på skolen? Er det mulig å finne faktorer som kan gi bedre mestring og skolefungering hos disse barna? Prosjektet er en prospektiv kohortstudie som er et samarbeid mellom Spesialsykehuset for epilepsi (SSE), Norsk epilepsiforbund, Folkehelseinstituttet og Universitetet i Edinburgh. Vi vil bruke den norske mor, far og barnundersøkelsen (MoBa) der 112 700 barn deltar. Vi bruker MoBa spørreskjema og epilepsidiagnoser registrert i Norsk pasientregister til å finne barna med epilepsi. Diagnosene valideres og karakteriseres ved journalgjennomgang. Skoleresultater hentes fra nasjonale skoleprøver. Ved å undersøke epilepsi og skoleresultater håper vi å finne faktorer som en kan påvirke, og dermed hjelpe barn med epilepsi til å få en bedre prognose og skolehverdag

Long-Term improvement after combined immunomodulation in early post-H1N1 vaccination narcolepsy

We previously described the possible clinical effects of early monotherapeutic IV-immunomodulation (IVIg) treatment in sporadic1 but not in postH1N1 vaccination narcolepsy type 1 (NT1).2 We report here an early post-H1N1 vaccination NT1 case treated with combined immunomodulation of IVIg and methylprednisolone, and a comparable sporadic NT1 case

Racemic Adrenaline and Inhalation Strategies in Acute Bronchiolitis

Acute bronchiolitis in infants, which frequently leads to hospitalization and sometimes requires ventilatory support, is occasionally fatal; it is usually viral in origin, with respiratory syncytial virus being the most common cause. The clinical disease is characterized by nasal flaring, tachypnea, dyspnea, chest retractions, crepitations, and wheezing. Bronchodilators are not recommended but are often used in the treatment of bronchiolitis, as are saline inhalations. Adrenaline reduces mucosal swelling, giving it an edge over the β2-adrenergic agonists, and has led to the frequent use of inhaled adrenaline, which has improved symptoms and reduced the need for hospitalization in outpatients with acute bronchiolitis. Among inpatients, however, inhaled adrenaline has not been found to reduce the length of the hospital stay. Assessment of the possible influences of age, sex, and status with respect to an asthma predisposition on the effect of inhaled adrenaline requires large multicenter studies. Inhaled nebulized solutions can be prescribed for use on demand or on a fixed schedule. We were unable to find documentation on the comparative efficacy of these two strategies in children with acute bronchiolitis. We tested the hypothesis that inhaled racemic adrenaline is superior to inhaled saline in the treatment of acute bronchiolitis in infancy and that administration on a fixed schedule is superior to administration on demand. We also assessed whether age, sex, or status with respect to allergic diseases influenced treatment efficacy. Including: Letter to the Editor. Skjerven Håvard Ove, Carlsen Kai-Håkon og Carlsen Karin C Lødrup. Inhaled adrenaline in acute bronchiolitis. The New England Journal of Medicine 2013;369:1076-7. http://dx.doi.org/10.1056/NEJMc130896