66 research outputs found
Oxidative intramolecular cyclization reactions of Cinnamayl ethers mediated by cerium (IV) ammonium nitrate (CAN): a stereoselective synthesis of 3,4-trans-disubstitutedtetrahydrofuran derivatives
- Publication venue
- Arkat-USA, Inc
- Publication date
- 01/01/2003
- Field of study
Various alkoxy-cinnamyl cinnamyl ethers and an alkoxy-cinnamyl prenyl ether underwent stereoselective oxidative cyclizations on treatment with a methanolic solution of cerium(IV) ammonium nitrate to afford 3,4-trans- disubstituted tetrahydrofuran derivatives. Different products were obtained under aerobic and anaerobic conditions
Nonequilibrium steady states in a vibrated-rod monolayer: tetratic, nematic and smectic correlations
- Author
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2005
- Field of study
We study experimentally the nonequilibrium phase behaviour of a horizontal
monolayer of macroscopic rods. The motion of the rods in two dimensions is
driven by vibrations in the vertical direction. Aside from the control
variables of packing fraction and aspect ratio that are typically explored in
molecular liquid crystalline systems, due to the macroscopic size of the
particles we are also able to investigate the effect of the precise shape of
the particle on the steady states of this driven system. We find that the shape
plays an important role in determining the nature of the orientational ordering
at high packing fraction. Cylindrical particles show substantial tetratic
correlations over a range of aspect ratios where spherocylinders have
previously been shown by Bates et al (JCP 112, 10034 (2000)) to undergo
transitions between isotropic and nematic phases. Particles that are thinner at
the ends (rolling pins or bails) show nematic ordering over the same range of
aspect ratios, with a well-established nematic phase at large aspect ratio and
a defect-ridden nematic state with large-scale swirling motion at small aspect
ratios. Finally, long-grain, basmati rice, whose geometry is intermediate
between the two shapes above, shows phases with strong indications of smectic
order.Comment: 18 pages and 13 eps figures, references adde
BounceBack™ capsules for reduction of DOMS after eccentric exercise: a randomized, double-blind, placebo-controlled, crossover pilot study
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Delayed onset muscle soreness (DOMS) is muscle pain and discomfort experienced approximately one to three days after exercise. DOMS is thought to be a result of microscopic muscle fiber tears that occur more commonly after eccentric exercise rather than concentric exercise. This study sought to test the efficacy of a proprietary dietary supplement, BounceBack™, to alleviate the severity of DOMS after standardized eccentric exercise.</p> <p>Methods</p> <p>The study was a randomized, double-blind, placebo-controlled, crossover study. Ten healthy community-dwelling untrained subjects, ranging in age from 18–45 years, were enrolled. Mean differences within and between groups were assessed inferentially at each data collection time-point using t-tests for all outcome measures.</p> <p>Results</p> <p>In this controlled pilot study, intake of BounceBack™ capsules for 30 days resulted in a significant reduction in standardized measures of pain and tenderness post-eccentric exercise compared to the placebo group. There were trends towards reductions in plasma indicators of inflammation (high sensitivity C-reactive protein) and muscle damage (creatine phosphokinase and myoglobin).</p> <p>Conclusion</p> <p>BounceBack™ capsules were able to significantly reduce standardized measures of pain and tenderness at several post-eccentric exercise time points in comparison to placebo. The differences in the serological markers of DOMS, while not statistically significant, appear to support the clinical findings. The product appears to have a good safety profile and further study with a larger sample size is warranted based on the current results.</p
Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial
- Author
- Abraham J
- Abramson B
- Acheatel R
- Ahmed M
- Akhunova S
- Alegret JM
- Alonso-Pulpón L
- Amerena J
- Amkieh A
- Amlani M
- Anand D
- Anderson J
- Antolin JM
- Areses EL
- Arkhipov M
- Aroney C
- Arstall M
- Asfour A
- Ashchi M
- Auguadro C
- Azar R
- Balog C
- Banker D
- Barbarash O
- Barbarich V
- Bash Dianna
- Battaglia J
- Belenky D
- Benczur B
- BERNI Andrea
- Berti S
- Bertolet B
- Biasucci LM
- Black R
- Blanchard A
- Blonder R
- Bokern MJ
- Bosschaert M
- Braun-Dullaeus R
- Breedveld RW
- Brennan Danielle M.
- Brilakis E
- Broadwater S
- Bronisz M
- Bronzwaer PN
- Brown A
- Brown WV
- Browne K
- Burtt D
- Camp A
- Cannon K
- Cavender JB
- Cavender Matthew A.
- Cendon AA
- Cervinka P
- Chandna H
- Chandra S
- Chandrashekhar Y
- Chapidze G
- Chawla K
- Chernick R
- Chronos N
- Chumburidze V
- Collins N
- Constance C
- Corrada E
- Cortés JM
- Crowley S
- Csapo K
- Cuccia C
- Dabrowski M
- Dani S
- Dart A
- Davies C
- Delafontaine P
- Della-Siega A
- DeMets D
- Den Hartog F
- den Hartoog M
- Dengler T
- Denning S
- Derlaga B
- Devlin G
- Dezsi C
- Dinnyes J
- Dobrzycki S
- Doevendans P
- Dorsel T
- Dovgalevskiy Y
- Downes T
- Drenning D
- Drozdz J
- Drzewiecki A
- East C
- Eaton G
- Edes I
- Eich D
- Elliott J
- Ermoshkina L
- Esquivias GB
- Farshid A
- Faynyk A
- Fedele F
- Fernández JD
- Ferrier L
- Feskov O
- Fineschi M
- Franco SN
- French W
- Frey N
- Fulwani M
- Gebel J
- Genth-Zotz S
- Genís AB
- Gessek J
- Gielen S
- Gillespie E
- Gniot J
- Go B
- Goloborodko B
- Goloshchekin B
- González MJ
- Gordeev I
- Gormaz CL
- Gosselin G
- Goswami R
- Goya IL
- Gunalingam B
- Gupta S
- Guseva G
- Haldis T
- Haltern G
- Harding S
- Hart H
- Heckman MJ
- Hengstenberg C
- Henry P
- Hermans W
- Herrman J
- Heuer H
- Horak D
- Horowitz J
- Hubacek J
- Huff C
- Hulinsky V
- Hutyra M
- Huynh T
- Ilmer B
- Ingelmo JM
- Janik M
- Jarne EF
- Jay D
- Jukema J. Wouter
- Kahali D
- Kancz S
- Karpenko O
- Karpenko Y
- Kashou H
- Kastelein John J. P.
- Katerenchuk O
- Katzan I
- Kedhi E
- Keijzers M
- Khaisheva L
- Khintibidze I
- Kie SH
- Kiss R
- Kleiman N
- Klein G
- Klimovic T
- Klimsa Z
- Kmetzo J
- Kobulia B
- Kochmanski M
- Koenig W
- Koenig Wolfgang
- Kokis A
- Kopytsya M
- Korban E
- Kornacewicz-Jach Z
- Kostenko V
- Kovacs Z
- Koval O
- Kozhukhov S
- Kozlowski A
- Kraiz I
- Kreuzer J
- Kukuy E
- Kuznetsov V
- Lago VN
- Lai C
- Lamas G
- Lambert C
- Lapp H
- Lauer M
- Lavi S
- Leithäuser B
- Lenderink T
- Leschke M
- Libis R
- Lieberman S
- Liem A
- Lincoff A. Michael
- Linev K
- Lioy E
- Lochridge S
- Lok D
- Loussararian A
- Lu D
- Lupkovics G
- MacDonald L
- Madej A
- Magagnini E
- Mahar L
- Maly M
- Mamatsashvili M
- Mann J
- Marenzi G
- Markov V
- Marso S
- Martin Mde M
- Martin IH
- Martin L
- Mayer O
- McCullum K
- Megreladze I
- Mennuni M
- Menon Venu
- Merenda R
- Merkely B
- Miekus P
- Mikhin V
- Minisi A
- Miranda JM
- Monhart Z
- Monraats P
- Montero JS
- Moretti L
- Motovska Z
- Movahed M
- Mudra H
- Mukherjee A
- Muller G
- Musial W
- Möllmann H
- Nagy A
- Nambi Vijay
- Nava JS
- Navarro MJ
- Nicholls Stephen J.
- Nierop P
- Nissen
- Nogai K
- Oei F
- Ortiz AI
- Ovcharenko E
- Paradis JM
- Parikh K
- Parker J
- Peñaranda AS
- Pfeffer M
- Piscione F
- Pleva L
- Pluta W
- Polasek P
- Polgar P
- Polk D
- Pollock S
- Ponikowski P
- Prasad C
- Prati F
- Premchand R
- Prokhorov O
- Psuja P
- Pudil R
- Pérez MB
- Rajput R
- Ramaswamy G
- Rassi A
- Reichert P
- Rekosz J
- Rezkalla S
- Richardson J
- Rivera E
- Robertson R
- Rodes-Cabau J
- Roleau J
- Romero AJ
- Romo AI
- Ronaszeki A
- Ronner E
- Rosenberg M
- Rosenson Robert S.
- Rotterova H
- Rubio AM
- Ruda M
- Rudenko L
- Runquist L
- Rynkiewicz A
- Sangiorgi G
- Sanmartín M
- Sanz M
- Sanz RR
- Saucedo J
- Schwartz G
- Schwartz Gregory G.
- Seigel P
- Semenka J
- Senaratne M
- Sereg M
- Shaburishvili T
- Shah A
- Shalnev V
- Shishehbor M
- Shvarts Y
- Silverman P
- Simanenkov V
- Simonyi G
- Skelding K
- Soriano FR
- Speciale G
- Spinar J
- Stellbrink C
- Steven E. Hennekens C
- Stillabower M
- Strain J
- Strasser R
- Sultan P
- Suriano P
- Tans JG
- Testa R
- Thadani U
- Thompson P
- Timofeev A
- Tolerico P.
- Treasure C
- Trip MD
- Trivedi S
- Troquay R
- Uchino K
- Ujda M
- Urbano RH
- Vadaganelli P
- Vakaliuk I
- Valgimigli M
- van de Wetering ML
- van der Heijden R
- van Gaal W
- van Wijk L
- Veen G
- Vertes A
- Vest A
- Vijay N
- Vishnevsky A
- Voehringer HF
- Volkova E
- Wachter R
- Werner N
- White M
- Wiley M
- Wilkins G
- Williams J
- Witkowski A
- Wright R. Scott
- Wysokinski A
- Youssef G
- Zadra R
- Zateyshchikov D
- Zishiri E
- Zubiri JJ
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2014
- Field of study
IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. OBJECTIVE: To determine the effects of sPLA2inhibition with varespladib on cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). INTERVENTIONS: Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. MAIN OUTCOMES AND MEASURES: The primary efficacy measurewas a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. RESULTS: At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95%CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95%CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). CONCLUSIONS AND RELEVANCE: In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA2inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01130246. Copyright 2014 American Medical Association. All rights reserved
Prevalence of drug-resistant pulmonary tuberculosis in India: systematic review and meta-analysis
- Author
- A Angrup
- A Dalal
- A Gupta
- A Gupta
- A Jain
- A Jain
- A Jain
- A Jain
- A Khanna
- A Martin
- A Thomas
- A Udaykumar
- AB Bloch
- AK Maurya
- AR Shah
- B Anuradha
- B Mahadev
- B Malhotra
- BR Velayutham
- BS Datta
- C Kailash
- C Nagaraja
- C Paramasivan
- C Porwal
- C Ravindran
- CK Mlambo
- CN Deivanayagam
- CN Paramasivan
- CN Paramasivan
- CN Paramasivan
- D Agrawal
- D Almeida
- D Lukoye
- D Rosha
- DJ Sloan
- DT D'Souza
- EW Orenstein
- GB Migliori
- GS Gaude
- H Gupta
- HR Stagg
- HS Subhash
- J Ayieko
- J Bhat
- J Rawat
- JKSD Mishra
- JP Higgins
- JP Mathuria
- K Chand
- K Duraisamy
- KL Therese
- KL Therese
- KS Sachdeva
- M Hanif
- M Nagpal
- MJ Magee
- MR Joseph
- MTS Pereira
- MW Uplekar
- N Chakraborty
- N Hemvani
- N Selvakumar
- N Singh
- NDS Pradhan
- P James
- P Kumar
- Prashant Narang
- R Ramachandran
- R Ranganath
- R Singhal
- R Singhal
- R Thirumurugan
- R Vasanthakumari
- R Yadav
- RS Wallis
- S Bhat
- S Kandi
- S Lahiri
- S Menon
- S Prajapati
- S Rajasekaran
- S Sethi
- SA Nair
- SBV Vijay
- SD Ahuja
- SK Jain
- SK Sharma
- SK Sharma
- SK Sharma
- SP Rai
- T Sagar
- V Vadwai
- Vijay Kadam
- Vikram Singh
- Vishal Goyal
- VP Myneedu
- VP Myneedu
- WA Wells
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial
- Author
- Abarca Javiera
- Abarca Luis
- Abdlaziz Ihab
- Abraham Valsamma
- Accetta Riccardo
- Adhye Bharati Anil
- Adili Anthony
- Adinarayanan S
- Aframian Arash
- Aguado Hector J
- Aguilar Marc
- Ahmed Tashfeen
- Ahn Henry
- Ali Arif
- Almas Ayesha
- Alvarado Kim A
- Ambroży Wojciech
- Anaya Rafael
- Andres-Peiro Jose-Vicente
- Anjum Anila
- Arnuntasupakul Vanlapa
- Arroyo Marta
- Ashraf Mohammed
- Ashraf Muhammad
- Atrey Amit
- Avram Victoria RA
- Balaguer-Castro Mariano
- Balasubramanian Kumar
- Balonov Konstantin
- Bangdiwala Shrikant I
- Bardana Davide D
- Barnawal Satish Prasad
- Bartley Debra
- Baños Victoria
- Beaupre Lauren
- Begum Dilshad
- Belley-Cote Emilie P
- Bentoumi Souad
- Beretta Luigi
- Bergese Sergio D
- Bernaus Martí
- Beroud Sebastien
- Bhandari Mohit
- Bhutia Jigme Tshering
- Biccard Bruce M
- Bicknell Ryan T
- Bidkar Prasanna Udupi
- Bilchod Prashanth Nabhirajappa
- Binda Mirko
- Biscardi Anna
- Bisland Stuart
- Bogallo Jose Manuel
- Bohm Eric R
- Bokhari Syedah Saira
- Bonadies Marika
- Boon Huck Wee
- Borate Madhav Pandurang
- Borges Flavia K
- Brokelman Roy B.G.
- Campbell Aaron R
- Campbell Ryan Jonathan
- Cano Juan Ramon
- Carey Timothy
- Carreras-Castañer Anna
- Cassidy Charles
- Castillón Pablo
- Cecconi Maurizio
- Chalacheewa Theerawat
- Chandran Nitheesh
- Chaudier Philippe
- Chaw Sook Hui
- Chee KH
- Chen Brian P-J
- Chetty Sean
- Chin Im Im
- Choi Stephen
- Chouhan Devendra K
- Clark Molly E
- Clinckaert Carol
- Cobben Jan-Hein MG
- Coles Chad P
- Colnaghi Eleonora
- Colombo Chiara
- Colomina Maria J
- Comstock Curt
- Conen David
- Cornu Olivier
- Correia Patricia
- Coughlin Ryan
- Coupal Stephanie A
- Cowan David D
- Crawford Gordon A
- Cruz Encarnacion
- Cullinan Claude
- Cámara-Cabrera Jaume
- Daniels Timothy R
- Dashputra Ravi Prabhakar
- David Jean Stephane
- de Beer Justin
- De Blasio Giuseppe
- De Caso Julio
- De Clippeleir Dirk
- Dealbert Alfred
- Deheshi Benjamin
- Dehghan Niloofar
- Denaro Giuseppe
- Devereaux PJ
- Dhillon Mandeep S
- Dillane Derek
- Dillingham Sally
- Ding Anthony
- Dongre Himanshu Vijaykumar
- Douplat Marion
- Dragic-Taylor Sanela
- Dresser George K
- Droll Kurt
- Duncan Andrew W
- Dąbek Piotr
- Elnaggar Mohamed
- Elskamp-Meijerman Hannie F
- Estrada Cristina
- Fang Christian Xinshuo
- Farooque Kamran
- Farrell Janet C
- Fayet Jean Marie
- Feibel Robert J
- Feijoo-Massó Carlos
- Fergusson Dean A
- Fessy Michel Henri
- Firth Gregory Bodley
- Flikweert Elvira R
- Flint Margot
- Foo Li Lian
- Forget Patrice
- Fourtounas Maria
- Fozzato Stefania
- Fraguas-Castany Antoni
- Frank Christopher C
- Friggeri Arnaud
- Furgan Ahmad
- Gallant Catherine
- Gamangati Shivanand
- Garcia-Sanchez Yaiza
- Garg Amit X
- Garrido Clua Miriam
- Gattu Uttam Vaidya
- Gauthier Leslie P
- George Carolin Elizabeth
- George Preetha Elizabeth
- Georgekutty AM
- Giardina Giuseppe
- Giilck Stephen M
- Gnanadurai Kingsly Robert
- Gonzalez Posada MA
- Gonzalez Zacarias Alicia A
- Grant Heather
- Greene James
- Gregus Krysten K
- Grzelak Adrian
- Gucwa Jaroslaw
- Guerado Enrique
- Guerra-Farfan Ernesto
- Guilabert Patricia
- Gupta Babita
- Guy Pierre
- Guyatt Gordon H
- Guzzetti Luca
- Gómez Olga
- Hadden William J
- Haider Syed Y
- Haire Kevin
- Hall Jeremy A
- Halman Samantha
- Harrison Mark M
- Harvey Valerie
- Hashmi Pervaiz Mehmood
- Henry Patrick DG
- Herranz Susana
- Herrera-Mateo Sergio
- Higa-Sansone JL
- Hiremath Santosh Angad
- Horst Maarten R
- Hunt Stephen B
- Hupel Tom
- Imbuldeniya Arjuna
- Iqbal Muhammad Nasir
- Irwin Marleen
- Ivanov Alexia
- Jacka Michael J
- Jaeger Melanie T
- Janjua Kholood Abid
- Jawali Abhijit
- Jenkinson Richard J
- John Bobby
- John Joby
- Jornet-Gibert Monsant
- Joseph Katherine
- Joseph Philip G
- Juman Naveed Muhammed
- K Varghese Zachariah
- Kadry Miriam Adel
- Karbassi Arsha
- Karera Mwalimu
- Kearon Clive
- Khan Abdus Salam
- Khan Eraj Khurshid
- Khan Hammad Naqi
- Khan Moin
- Khan Muhammad Kashif
- Khan Robyna Irshad
- Khan Siddra Ahmed
- Khanna Vickas
- Khattak Mujahid Jamil
- Khor HM
- Khoshbin Amir
- Kishta Waleed
- Kleinlugtenbelt Ydo V
- Koo Kevin
- KP Mary KP
- Kreder Hans J
- Kudrimoti Kiran Bhalchandra
- Kulachote Noratep
- Kumar CS
- Kumoń Adam
- Kunz Monica R
- Labrador Gregorio
- Lai Hou Yee
- Lakdawala Riaz Hussain
- Lal Purushotham
- Lalueza-Broto Pilar
- Lamy Andre
- Landais Paul
- Landman Ellie BM
- Landoni Giovanni
- Lavand'homme Patricia
- Lawendy Abdel-Rahman
- Lawrence Kelly H
- Le Manach Yannick
- le Polain de Waroux Bernard
- Lee Jacques S
- Lee Meng-Li
- Lefrancois Tina
- Leong Darryl P
- Leung Frankie Ka Li
- León Ricardo
- Liu Yang
- Loh PS
- Louboutin Lucie
- M Niranjan
- MacDonald Anne Marie
- MacDonald Shelley
- Machala Waldemar
- Macho Oscar
- Macleod Mark D
- Maddipati Tatarao
- Magloire Patrick
- Malhotra Rajesh
- Maluleke Matimba Lenny
- Mann Stephen M
- Maqungo Sithombo
- Marcantonio Andrew J
- Marcato Anna
- Marcucci Maura
- Marion Travis
- Marmor Meir T
- Martin Nuria
- Martinez-Municio Gonzalo
- Martinez-Ripol Pedro
- Martínez-Sañudo Luis
- Mateo Llorenç
- Mathur Purva
- Matityahu Amir
- Maxwell Chelsea
- Mayor Amy SE
- McClellan Robert Trigg
- McGillion Michael H
- McIlquham Katie
- McLean Lisa M
- McMahon Stephen J
- Menon Jagdish
- Menon Matthew
- Menon Prem Haridas
- Mestre-Torres Jaume
- Millan Angelica
- Minguell-Monyart Joan
- Mishra Sandeep Kumar
- Mittal Samarth
- Molero-Garcia Vicente
- Moller Carien
- Molnar Sarah
- Moppett Iain K
- Morelli Ilaria
- Mozzon Lise
- Mustafa Khawaja Junaid
- Muñoz Juan Manuel
- Naidoo Rubendren
- Nam Diane
- Nanjayan Shashi Kumar
- Naratreekoon Bundit
- Narayan Ravi
- Nauth Aaron
- NC Madhusudhan
- Neary John D
- Nejthardt Marcin B
- Ngim Joanne HL
- Nhlapo Lerato
- Nicholson Laura
- Noordin Shahryar
- Nousiainen Markku
- Novellas Marga
- Nur Aamer Nabi
- Nuñez Camarena Jorge
- O'Brien Peter J
- O'Sullivan Susan
- O'Toole Robert
- Olivieri Loretta
- Omran Sherif
- Orakzai Sajjad Hassan
- Oxner William
- Oyenubi Ademilola N
- Pandey Ritesh Arvind
- Parker Martyn J
- Patel Ameen
- Patil Atul Ashok
- Patil Sharanu
- Patil Shashank
- Payendeh Jubin
- Paños Gozalo M Luisa
- Peig-Font Anna
- Pengrung Nachapan
- Perazzo Paolo
- Pettit Shirley M
- Pey Borja
- Phieffer Laura S
- Piccirillo Fabio
- Pino Fabio
- Piriou Vincent
- Placella Giacomo
- Ploeg Leone
- Popova Ekaterine
- Porcel-Vazquez Juan A
- Pradhan Chetan Vijay
- Prakasam Komella
- Puram Chetan Prabhakar
- Puskas David
- Quintas Saioa
- Quraishi Faraaz A
- Rahate Prashant Vitthal
- Rajkumar Arti
- Ramokgopa Mmampapatla T
- Ramokgopa Mmampapatla Thomas
- Rashid Haroon Ur
- Rashid Rizwan Haroon
- Ravi Bheeshma
- Reul Maike
- Riaz Muhammad Mehmood
- Richardson C Glen
- Ricol Laura
- Roerdink Herbert W
- Ruggiero Sara
- Ryan Scott P
- Rycombel Jacek
- Sa-ngasoongsong Paphon
- Sadoughi Mehdi
- Salini Vincenzo
- Salomó-Domènech Mònica
- Salvador Jordi
- Sancheti Parag K
- Sancheti Parag Kantilal
- Sanchez-Raya Judith
- Sanders David W
- Santiago-Maniega Silvia
- Santone David J
- Satora Wojciech
- Sawhney Chavi
- Schemitsch Emil
- Schemitsch Emil H
- Sciadini Marcus
- Selga Marsa Jordi
- Serrano-Sanz Jorge
- Shadowitz Steven
- Shan Lei
- Shanthanna Harsha
- Sharma Achal
- Sharma Deep
- Sharma Vijay
- Shirali Hemant R
- Shiraz Muhammad
- Shrikumar Mopina
- Sianes-Gallén Mònica
- Sigamani Alben
- Sigamani Alen
- Simpson Diane L
- Singh Simmrat
- Singh Surya Udai
- Singh Virsen
- Sirisreetreerux Norachart
- Sivilotti Marco LA
- Slobogean Gerard
- Smith Christopher A
- Smith Crystal A
- Sohail Mian Amjad
- Stella Daniele
- Stephen David JG
- Stephen Manesh
- Stiegelmahr Robert
- Sulthan Ahamad Shaheel
- Swaminathan Srinivasan
- Szczeklik Wojciech
- Tan Kit Mun
- Tandon Vikas
- Teixidor-Serra Jordi
- Thayaparan Surendini
- Thiruganasambandamoorth Venkatesh
- Tiboni Maria E
- Tieszer Christina
- Tomas-Hernandez Jordi
- Toogood Paul
- Torner Pere
- Torra Mercè
- Touil Nassim
- Tran Sarah
- Trask Kelly
- Trenholm J Andrew I
- Tribak Karim
- Tripathy Vijaylaxmi
- Tuazon Ravianne
- Turgeon Thomas R
- Turiel Maurizio
- Tushinski Daniel M
- Umar Muhammad
- Umer Masood
- Usua Gemma
- Valldosera Esther
- Vasarhelyi Edward
- Veevaete Laurent
- Villar-Casares Maria del Mar
- Vincent Jessica
- Vizcaychipi Marcela Paola
- Wahab Hussain
- Wang Chew Yin
- Ward Sarah E
- Wasserstein David
- Watts Evan
- Wells Jennifer R
- Whelan Daniel B
- White Neil J
- Whitlock Richard
- Wikkerink Spencer
- Wilson David AJ
- Winemaker Mitchell
- Wong Steven CW
- Wood Gavin CA
- Wood Thomas J
- Worster Andrew
- Wright Douglas Steven
- Wu Anshi
- Yach Jeff D
- Yee Allan J
- Yee Dennis King Hang
- Yela-Verdú Christian
- Yingchoncharoen Teerapat
- Yombi Jean Cyr
- Yuste Antoni
- Yusuf Salim
- Zabalza Ana
- Zaki Amna
- Zhao Yanrui
- Zhou Junlin
- Ślęczka Paweł
- Święch Mariusz
- Publication venue
- 'Elsevier BV'
- Publication date
- 29/02/2020
- Field of study
Recommended from our members
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
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- Daly James
- Daly Zoe
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- Dark Paul
- Darreau Cédric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
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- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
- Dragija Lidija
- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
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- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
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- Estcourt Lise
- Estcourt Lise
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- Everitt Robert
- Evers Mirjam
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- Faulkner Maria
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- Ferguson Niall
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- Finn Stephanie
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- Fitzgerald Mark
- Fitzgerald Mark
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- Forbes Loretta
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- Fowler Robert
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- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
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- Geng Wenli
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- Ghamraoui Ali
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- Girard Timothy
- Girijadevi Dinu
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- Goodwin Jayne
- Goossens Herman
- Goossens Herman
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- Gordon Elizabeth
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- Grimwade Kate
- Guilder E
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- Hacking Danielle
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- Hall Kathryn
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- Higgins Lisa
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- Horton Sarah
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- Horvat Christopher
- Howcroft Clare
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- Hullegie Sebastiaan J
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- Johnston Paul
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- Kruger Peter
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- Kumar Nikhil
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- Lamontagne Francois
- Lamontagne François
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- Lane Janis-Best
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- Laver Russell
- Lawler Patrick
- Lawler Patrick R
- Lawless Patrick
- Lazaro Juan Martin
- Leaver Susannah
- Leblond Julie
- Lee Kelvin
- Lee Stephanie
- Leparco Cécile
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- Leszkoven János
- Lewis Roger
- Lewis Roger J
- Lewis Sarah
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- Limb James
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- Linstrum Kelsey
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- Litton Edward
- Litton Edward
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- Lorenzi Elizabeth
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- Mackay Euan
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- Marroquin Oscar
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- Marshall John
- Marshall Nicola
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- McArthur Colin
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- McAuley Daniel
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- Mouncey Paul
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- Panwar Rakshit
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- Reschreiter Henrik
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- Reynolds John
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- Ricketts Daniel
- Rietveld Ilse
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- Sagnier Anne
- Salazar Degracia Anna
- Salerno Tania
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- Seymour Christopher
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- Shrestha Tapaswi
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- Simmonds Catherine
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- Smith John
- Smith Judith
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- Spivey Michael
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- Stanworth Simon
- Sterba Martin
- Stevenson Hannah
- Stewart Richard
- Strzelecka Anna
- Sundara Raman Ajay
- Sundaran Dhinesh
- Sutherland Helen
- Sutterlin Laetitia
- Sutu Mihaela
- Sweet Katie
- Szakmany Tamas
- Szigligeti Gábor
- Szőke Viktória
- Tallott Mandy
- Tatham Kate Colette
- Templeton Maie
- Thomas Amy
- Thomas Helen
- Thomas Matt
- Thomas Matthew
- Thompson Taylor
- Thomson Nicola
- Thrush Jessica
- Tilney Emma
- Tinmouth Alan
- Tong Steve
- Tooley Joe
- Touma Omar
- Trapani Tony
- Trask Kara
- Triulzi Darrell
- Trodd Dawn
- Tsang Jennifer
- Tully Redmond
- Turgeon Alexis
- Turki Salah
- Turner Anne
- Turner Anne
- Turner-Bone Ian
- Turns Margaret
- Uddin Ruzena
- Udy Andrew
- Uyeki Tim
- Vaara Suvi
- Vahtera Annukka
- Vamplew Luke
- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
- Verrier Nathalie
- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
- Vowell Emma
- Vujaklija Brajković Ana
- Vuylsteke Alain
- Wagh Atul
- Walden Andrew
- Walker Rachel
- Walsh Joanne
- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos A.
- Abbas A.M.
- Abbas M.
- Abbasi M.
- Abbott T.
- Abdalaal I.
- Abdel-Galil K.
- Abdelemam R.
- Abdelgawad A.
- Abdelkarim M.
- Abdelkhalek M.
- Abdelmageed A.
- Abdelmawgoud S.
- Abdelmohsen S.
- Abdelrahman A.S.
- Abdelrahman M.
- Abdelwahab K.
- Abdou H.
- Abdulai D.R.
- Abdulkhaleq M.
- Abdullah B.
- Abdulsalam K.
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- Abdur-Rahman L.
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- Šantak G.
- Šimko K.
- Žatecký J.
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
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- Ajith Parameswaran
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- Akseli Hannuksela Otto
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- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
- …