Death of an expert system: A case study of success and failure

A decision team composed of managers and staff experts at Mary Kay Cosmetics develops packaging for new and revised products as well as sets their prices. However, the potential for costly errors in the decision-making process motivated this group to pursue development of an expert system (ES) to assist with the problem. The ES performed so well that it changed the organization\u27s behavior—the group ceased to meet for the purpose of developing the packaging but instead gathered just to confirm and approve the expert system\u27s solution. Despite the clear benefits associated with using an ES approach, the group stopped using the ES application and the behavior of the group returned to pre-ES practices. This work describes from a managerial perspective how and why this valuable tool fell into disuse, and offers valuable lessons for management

Inverse Cascade Regime in Shell Models of 2-Dimensional Turbulence

We consider shell models that display an inverse energy cascade similar to 2-dimensional turbulence (together with a direct cascade of an enstrophy-like invariant). Previous attempts to construct such models ended negatively, stating that shell models give rise to a "quasi-equilibrium" situation with equipartition of the energy among the shells. We show analytically that the quasi-equilibrium state predicts its own disappearance upon changing the model parameters in favor of the establishment of an inverse cascade regime with K41 scaling. The latter regime is found where predicted, offering a useful model to study inverse cascades.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let

Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment.

Agents that remodel the tumor microenvironment (TME), prime functional tumor-specific T cells, and block inhibitory signaling pathways are essential components of effective immunotherapy. We are evaluating live-attenuated, double-deleted Listeria monocytogenes expressing tumor antigens (LADD-Ag) in the clinic. Here we show in numerous mouse models that while treatment with nonrecombinant LADD induced some changes in the TME, no antitumor efficacy was observed, even when combined with immune checkpoint blockade. In contrast, LADD-Ag promoted tumor rejection by priming tumor-specific KLRG1+PD1loCD62L- CD8+ T cells. These IFNγ-producing effector CD8+ T cells infiltrated the tumor and converted the tumor from an immunosuppressive to an inflamed microenvironment that was characterized by a decrease in regulatory T cells (Treg) levels, a proinflammatory cytokine milieu, and the shift of M2 macrophages to an inducible nitric oxide synthase (iNOS)+CD206- M1 phenotype. Remarkably, these LADD-Ag-induced tumor-specific T cells persisted for more than 2 months after primary tumor challenge and rapidly controlled secondary tumor challenge. Our results indicate that the striking antitumor efficacy observed in mice with LADD-based immunotherapy stems from TME remodeling which is a direct consequence of eliciting potent, systemic tumor-specific CD8+ T cells

Timeflux: an open-source framework for the acquisition and near real-time processing of signal streams

International audienc

Passive Vaporizing Heat Sink

A passive vaporizing heat sink has been developed as a relatively lightweight, compact alternative to related prior heat sinks based, variously, on evaporation of sprayed liquids or on sublimation of solids. This heat sink is designed for short-term dissipation of a large amount of heat and was originally intended for use in regulating the temperature of spacecraft equipment during launch or re-entry. It could also be useful in a terrestrial setting in which there is a requirement for a lightweight, compact means of short-term cooling. This heat sink includes a hermetic package closed with a pressure-relief valve and containing an expendable and rechargeable coolant liquid (e.g., water) and a conductive carbon-fiber wick. The vapor of the liquid escapes when the temperature exceeds the boiling point corresponding to the vapor pressure determined by the setting of the pressure-relief valve. The great advantage of this heat sink over a melting-paraffin or similar phase-change heat sink of equal capacity is that by virtue of the =10x greater latent heat of vaporization, a coolant-liquid volume equal to =1/10 of the paraffin volume can suffice

Benchmark enclosure fire suppression experiments - phase 1 test report.

A series of fire benchmark water suppression tests were performed that may provide guidance for dispersal systems for the protection of high value assets. The test results provide boundary and temporal data necessary for water spray suppression model development and validation. A review of fire suppression in presented for both gaseous suppression and water mist fire suppression. The experimental setup and procedure for gathering water suppression performance data are shown. Characteristics of the nozzles used in the testing are presented. Results of the experiments are discussed