2 research outputs found
Atom- and Step-Economical Preparation of Reduced Knoevenagel Adducts Using CO as a Deoxygenative Agent
A highly efficient
one-step Rh-catalyzed preparation of reduced
Knoevenagel adducts of various aldehydes and ketones with active methylene
compounds has been developed. The protocol does not require an external
hydrogen source and employs carbon monoxide as a deoxygenative agent.
The use of malonic acid or cyanoacetamide enabled efficient formal
deoxygenative addition of methyl acetate or acetonitrile to aldehydes.
The developed methodology was applied to the synthesis of the precursors
of biomedically important compounds
Cyclobutadiene Metal Complexes: A New Class of Highly Selective Catalysts. An Application to Direct Reductive Amination
A catalyst
of a new type, cyclobutadiene complex [(C<sub>4</sub>Et<sub>4</sub>)ÂRhÂ(<i>p</i>-xylene)]ÂPF<sub>6</sub>, was
found to promote selective reductive amination in the presence of
carbon monoxide under mild conditions (1–3 bar, 90 °C).
The reaction demonstrated perfect compatibility with a wide range
of functional groups prone to reduction by conventional reducing agents.
The developed system represents the first systematic investigation
of cyclobutadiene metal complexes as catalysts