Atom- and Step-Economical Preparation of Reduced Knoevenagel
Adducts Using CO as a Deoxygenative Agent
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Abstract
A highly efficient
one-step Rh-catalyzed preparation of reduced
Knoevenagel adducts of various aldehydes and ketones with active methylene
compounds has been developed. The protocol does not require an external
hydrogen source and employs carbon monoxide as a deoxygenative agent.
The use of malonic acid or cyanoacetamide enabled efficient formal
deoxygenative addition of methyl acetate or acetonitrile to aldehydes.
The developed methodology was applied to the synthesis of the precursors
of biomedically important compounds