Poles of Archimedean zeta functions for analytic mappings

In this paper, we give a description of the possible poles of the local zeta function attached to a complex or real analytic mapping in terms of a log-principalization of an ideal associated to the mapping. When the mapping is a non-degenerate one, we give an explicit list for the possible poles of the corresponding local zeta function in terms of the normal vectors to the supporting hyperplanes of a Newton polyhedron attached to the mapping, and some additional vectors (or rays) that appear in the construction of a simplicial conical subdivision of the first orthant. These results extend the corresponding results of Varchenko to the case l\geq1, and K=R or C. In the case l=1 and K=R, Denef and Sargos proved that the candidates poles induced by the extra rays required in the construction of a simplicial conical subdivision can be discarded from the list of candidate poles. We extend the Denef-Sargos result arbitrary l\geq1. This yields in general a much shorter list of candidate poles, that can moreover be read off immediately from the Newton polyhedron

On `maximal' poles of zeta functions, roots of b-functions and monodromy Jordan blocks

The main objects of study in this paper are the poles of several local zeta functions: the Igusa, topological and motivic zeta function associated to a polynomial or (germ of) holomorphic function in n variables. We are interested in poles of maximal possible order n. In all known cases (curves, non-degenerate polynomials) there is at most one pole of maximal order n which is then given by the log canonical threshold of the function at the corresponding singular point. For an isolated singular point we prove that if the log canonical threshold yields a pole of order n of the corresponding (local) zeta function, then it induces a root of the Bernstein-Sato polynomial of the given function of multiplicity n (proving one of the cases of the strongest form of a conjecture of Igusa-Denef-Loeser). For an arbitrary singular point we show under the same assumption that the monodromy eigenvalue induced by the pole has a Jordan block of size n on the (perverse) complex of nearby cycles.Comment: 8 pages, to be published in Journal of Topolog

Isolated Intraocular Relapse of Pediatric B-cell Precursor Acute Lymphoblastic Leukaemia Following Chimeric Antigen Receptor T-lymphocyte Therapy

Chimeric antigen receptor T-lymphocytes (CAR T) targeting the CD19 surface antigen have achieved a breakthrough in the treatment of multiply relapsed and refractory bone marrow (BM) disease in childhood B-cell precursor acute lymphoblastic leukaemia (B-ALL). The ability of CAR T therapy to treat extramedullary (EM) disease is less proven. However, early reports suggest trafficking of CART-cells to the central nervous system (CNS) as well as other EM sites. We describe a case of isolated intraocular relapse of pediatric B-ALL following CAR T-cell therapy, which had successfully controlled multiply relapsed BM and CNS disease. CAR T-cells may not be able to traffic into the eye, making it a "sanctuary" site during therapy

‘SeaStats’: hard figures on sea and coast

Looking for reliable figures on our seas and coasts? In need of that particular number to finish your introduction or presentation? ‘SeaStats’ offers interesting facts, each with a direct link to the source document and author(s). The primary criteria for selection are 1) reliability and quality of the source and 2) relevance of the figures. ‘SeaStats’ is a bilingual product that allows for a thematic search through 9 topics and 40 subtopics that are relevant marine, coastal and estuarine themes. ‘SeaStats’ wishes to a) facilitate the search for reliable anecdotic information on seas and coasts, with a focus on figures and numbers and 2) provide an additional exposure of marine and coastal research results to a wider public. Figures can be looked up through the 9 different symbols in the start-screen www.vliz.be/cijfers_beleid/zeecijfers (Dutch and English) or by filling in specific search terms. Take this example; you want to know the exact length of the Belgian coastline? Follow the symbol ‘Sea of space’ on the start-screen, click on ‘geography’, or use the search term ‘coastline’. The result of your search will inform you that there are 3 different and www.vliz.be/docs/Zeecijfers/seabordernl.pdf, where each alternative is explained. Source documents are by preference full texts of publications documented in IMIS, on relevant Belgian research or relating to the Belgian part of the North Sea, the Scheldt Estuary and the Belgian coastal zone

Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4+ T-cell reconstitution

Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4+-biased T-cell recovery after cord blood transplant. This enhanced T-cell reconstitution differs from that seen after stem cell transplant from other stem cell sources, but the mechanism is not known. Here, we demonstrate that the transcription profile of naive CD4+ T cells from cord blood and that of lymphocytes reconstituting after cord blood transplantation is similar to the transcription profile of fetal CD4+ T cells. This profile is distinct to that of naive CD4+ T cells from peripheral blood and that of lymphocytes reconstituting after T-replete bone marrow transplantation. The transcription profile of reconstituting naive CD4+ T cells from cord blood transplant recipients was upregulated in the T-cell receptor (TCR) signaling pathway and its transcription factor activator protein-1 (AP-1). Furthermore, a small molecule inhibitor of AP-1 proportionally inhibited cord blood CD4+ T-cell proliferation (P < .05). Together, these findings suggest that reconstituting cord blood CD4+ T cells reflect the properties of fetal ontogenesis, and enhanced TCR signaling is responsible for the rapid restoration of the unique CD4+ T-cell biased adaptive immunity after cord blood transplantation