Molecular Engineering of Conjugated Polymers for Sensor Applications

In recent years, the application of fluorescent conjugated polymers for sensing chemical and biological analytes has received much attention from many researchers. A promising development in this direction was the fabrication of conducting polymer-based sensors for the detection of metal ions, small organic molecules and biomolecules. Herein, we have designed, synthesized and studied a series of copolymers containing alternate phenylene and 2,5- or 2,6-substituted pyridine rings. The basic N-atom of the pyridine ring and the adjacent –OH group from the phenyl ring provide binding sites for metal ions. Another series of water-soluble conjugated polymers with propoxy sulfonate side chains are investigated for biosensor applications. Significant quenching of the polymer fluorescence upon addition of viologen derivatives was also observed. The quenching effect on the polymer fluorescence confirmed that the newly synthesized polymers can be useful in the application of metal and biological sensors.Singapore-MIT Alliance (SMA

Synthesis, Optical properties and Applications of Water Soluble Conjugated PPPs for Biosensors

In recent years, application of fluorescent conjugated polymers to sense chemical and biological analytes has received much attention owing to its technological significance. Water soluble conjugated polymers are interesting towards the developing sensors for biomolecules. In this present contribution, we describe the syntheses and characterization of a series of water soluble conjugated polymers with sulfonic acid groups in the side chain. Such anionic conjugated polymers are designed to interact with biomolecules such as cytochrome-C. All polymers are water soluble and showed strong blue emission. Significant quenching of the fluorescence from our functionalized PPP was observed upon addition of viologen derivatives or cytochrome -C.Singapore-MIT Alliance (SMA

Molecular Engineering of Amphiphilic Pyridine Incorporated Conjugated Polymers for Metal Ion Sensors

Recent developments in the synthesis and structure-property investigation studies of conjugated polymers have led to the design of novel polymeric materials with tailored properties for advanced technological applications. A promising development in this direction involves the fabrication of conducting polymer based sensors for the detection of metal ions and small organic molecules. Herein, we designed, synthesized and studied a series of amphiphilic copolymers containing alternate phenylene and 2,5- or 2,6- or 3,5-substituted pyridine rings. The basic N-atom of the pyridine ring and the adjacent –OH group from the phenyl ring provide binding sites for metal ions. Thermal properties, and optical properties of polymers in presence of acid, base and metal ions are investigated. A few target polymers showed high sensitivities for metal ions in solution.Singapore-MIT Alliance (SMA

Aromatherapy: The Power of Scent

An alternative (in medicine) is a substance that speeds up the renewal of the tissues so that they can carry out their functions more efficiently. Aromatherapy is one such method of healing, using volatile oils. This article was prepared to give the reader more information on the usage of essential oils

Studies on Some Pharmacognostic Profiles of \u3cem\u3eBauhinia purpurea\u3c/em\u3e Linn. Leaves (Caesalpinaceae)

The leaves of Bauhinia purpurea Linn. were studied with the aim of determining the following pharmacognostical parameters for this species: Macroscopical characters; Leaf constants; Physico-chemical constants; Extractive values; Colour; Consistency; Extractive values with different solvents; Micro chemical tests; Fluorescence characters of liquid extracts and leaf powder after treatment with different chemical reagents under visible and UV light at 254 nm & 366 nm; Measurement of cells and tissues; Bulk density angle of repose; and, Powder microscopy. Hopefully, the determination of these characteristics will aid future investigators in their pharmacological analyses of this species. Preliminary pytochemical studies on different extracts of the leaves were also performed

Avvaiyar's thoughts on life guide

Among the poets of Tamil literature, Avvaiyar has carved a niche for himself by his ability to express himself through knowledge, personality, erudition and erudition. In his history of Tamil literature, M. Arunachalam mentions that there lived six women poets in the name of Avvaiyar. Avvaiyar, who wrote books like Aathisudi, Konrai Vendan, Nalvazhi and Moothurai during the Chola period, is the avvaiyar of our article. It is a Tamil law book and derives its name from the fact that it describes the good ways that people should follow in their lives in Nerisai Venba. This article goes on to tell the family and the individual in many ways that the society should avoid wasteful expenditures and spend on the budget and that the air tip is the best and the sweet word is the best

Locomotor Activity of Leaf Extracts of \u3cem\u3ePithecellobium dulce\u3c/em\u3e Benth.

Objective: To study Locomotor activity of aqueous and alcoholic extracts of leaves of Pithecellobium dulce Benth. Materials and methods: CNS depressant activity of leaf extracts of P. dulce was evaluated using actophotometer in albino mice. The potency of alcoholic and aqueous extracts of leaf was compared with that of chlorpromazine at a dose of 100 mg/kg. The acute toxicity was determined using albino mice. Results: Both extracts caused significant CNS depression action in albino mice. The activity of alcoholic extract was more, when compared to chlorpromazine. Conclusion: CNS depression action of extracts may be due to increase in the concentration of GABA in brain

Free Radical Scavenging Activity of Folklore: \u3cem\u3ePithecellobium dulce\u3c/em\u3e Benth. Leaves

In the present study, the aqueous and alcoholic extract of Pithecellobium dulce leaves were evaluated for radical scavenging activity using reducing power assay method. Aqueous extract showed potent free radical scavenging activity, than alcohol extract. The observed activity could be due to higher phenolic content in the extracts (0.2171& 0.2042 mg/g in aqueous and alcohol extract respectively). HPTLC fingerprint profile of the ethanol and aqueous extracts were developed which would serve as reference standard for quality control of these extract