Quelles contre-propositions ouvrières lors des restructurations industrielles en Wallonie de 1959 à 1984 ?

Parcourant vingt-cinq ans de l’histoire industrielle de Wallonie, cet article offre une analyse des contre-propositions industrielles portées par les collectifs ouvriers lors des restructurations qui affectent leur secteur d’activité entre 1959 et 1984. Après, ou à côté de, l’opposition à la fermeture de leur lieu de travail, ils se sont inspirés de l’émergence ou de l’absence de nouveaux paradigmes économiques pour proposer leurs solutions originales de reclassement. Les notions de répartition économique régionale, de post-industrialisation, de tertiarisation, d’entrepreneuriat et d’économie de marché se trouvent réappropriées par les collectifs ouvriers pour formuler d’autres scénarii de reconversion, plus ou moins réalistes. Contre-propositions ouvrières en WallonieLooking at twenty-five years of industrial history in Wallonia, this article provides an analysis of workers’ strategies during an industrial restructuring period that spans from 1959 to 1984. Beyond their opposition to the closure of their factory, workers developed strategies aiming to overcome this upsetting event and formulate their own reemployment alternatives. These strategies rest upon a blurry interpretation of economic paradigms which epitomized the restructuring context in its historical dimension. Notions such as balanced regional economic growth, postindustrial society, service economy, entrepreneurship and free market economy were claimed by these dismissed workers and considered as a way out of the restructuring crisis in the industrial or manufacturing sector

Tropical Tree Cover in a Heterogeneous Environment: A Reaction-diffusion Model

Observed bimodal tree cover distributions at particular environmental conditions and theoretical models indicate that some areas in the tropics can be in either of the alternative stable vegetation states forest or savanna. However, when including spatial interaction in nonspatial differential equation models of a bistable quantity, only the state with the lowest potential energy remains stable. Our recent reaction-diffusion model of Amazonian tree cover confirmed this and was able to reproduce the observed spatial distribution of forest versus savanna satisfactorily when forced by heterogeneous environmental and anthropogenic variables, even though bistability was underestimated. These conclusions were solely based on simulation results. Here, we perform an analytical and numerical analysis of the model. We derive the Maxwell point (MP) of the homogeneous reaction-diffusion equation without savanna trees as a function of rainfall and human impact and show that the front between forest and nonforest settles at this point as long as savanna tree cover near the front remains sufficiently low. For parameters resulting in higher savanna tree cover near the front, we also find irregular forest-savanna cycles and woodland-savanna bistability, which can both explain the remaining observed bimodality.Comment: 28 pages, 6 figures, 2 tables, supplementary info include

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins is emerging as a promising therapeutic strategy. Despite intense efforts to rationally design degrader molecules that co-opt CRL4s, much about the organization and regulation of these ligases remains elusive. Here, we establish protein interaction kinetics and estimation of stoichiometries (PIKES) analysis, a systematic proteomic profiling platform that integrates cellular engineering, affinity purification, chemical stabilization, and quantitative mass spectrometry to investigate the dynamics of interchangeable multiprotein complexes. Using PIKES, we show that ligase assemblies of Cullin4 with individual substrate receptors differ in abundance by up to 200-fold and that Cand1/2 act as substrate receptor exchange factors. Furthermore, degrader molecules can induce the assembly of their cognate CRL4, and higher expression of the associated substrate receptor enhances degrader potency. Beyond the CRL4 network, we show how PIKES can reveal systems level biochemistry for cellular protein networks important to drug development

Evaluating the impact and cost-effectiveness of chlamydia management strategies in Hong Kong:A modeling study

OBJECTIVES: To illustrate the epidemiologic and cost-effectiveness impact of shifting the focus from population-based screening toward a targeted management approach for genital chlamydia infection. DESIGN: Modeling study, implementing an individual-based, stochastic, dynamic network model. SETTING: Hong Kong. POPULATION: A hypothetical sample network of 10,000 people with a partnership distribution based on Hong Kong's sexually active population of reproductive age (age 18–49 years). INTERVENTIONS: In this study, we present several scenarios with different implementations of universal vs. targeted screening (based on partner numbers). We also explored the impact of (1) screening only, (2) screening plus expedited partner therapy, and (3) screening plus partner testing. PRIMARY OUTCOME MEASURES: Change of chlamydia prevalence before and after implementing the different strategies. The cost-effectiveness analysis reports total direct cost from a health provider perspective, the QALYs gained, and incremental cost-effectiveness ratios (ICER). RESULTS: In comparing the effects of universal screening only and targeted screening of the high-risk population, the mean prevalence during the 10th year of intervention was 2.75 ± 0.30% and 2.35 ± 0.21%, respectively (compared with 3.24 ± 0.30% and 3.35 ± 0.21% before the interventions, respectively). The addition of contact tracing to the latter targeted screening scenario reduces the mean prevalence during the 10th year of intervention to 1.48 ± 0.13% (compared with 3.31 ± 0.33% at baseline) in the best-case of testing before treatment and maximal contact-tracing effectiveness (40%). Overall, the most effective scenarios were those for which interventions focused on the high-risk population defined by the number of partners, with contact tracing included. The ICER for targeted screening with contact tracing at 20% and 40% efficiency was $4,634 and$7,219 per QALY gained, respectively (10-year time horizon). Expedited partner therapy did not significantly impact overall chlamydia prevalence and caused overtreatment. CONCLUSIONS: Our study suggests that targeted screening with strengthened contact tracing efforts is the most cost-effective strategy to reduce the prevalence of chlamydia in Hong Kong

Enhancing Safety: the Challenge of Foresight - ESReDA Project Group Foresight in Safety

This Deliverable is the result of a joint effort by experts, working in the fields of risks management, accident analysis, learning from experience and safety management. They come from 10 countries mainly from Europe and also from USA and Australia. Their expertise covers several industrial sectors. They attempted to provide useful information, both from a theoretical and a practical point of views, about "Foresight in Safety". Safety is still an ongoing issue for which a number of subjects remain under debate (e.g. is goal of safety to ensure that 'as few things as possible go wrong' or to ensure that ‘as many things as possible go right’?). Anyway, we can assume that safety is to act in a way for both the process continues to be run right and that errors and failures to not lead to a major accident. Even if "foresight in safety" is the implicit underlying goal of every practitioner in safety, the outlines of its domain remain blurred and the relevant topics associated with it have never been clearly defined. A humble ambition of this Deliverable is to display some aspects of "foresight in safety" according to the current state of practices and scientific knowledge.JRC.G.10-Knowledge for Nuclear Security and Safet

Crises et intégration européenne. Experts et pratiques de la restructuration industrielle durant les années 1960

info:eu-repo/semantics/publishe

Mineur au front, soldat au fond

info:eu-repo/semantics/nonPublishe