Multimorbidity worsened anxiety and depression symptoms during the COVID-19 pandemic in Brazil

Multimorbidity is a global health issue impacting the quality of life of all ages. Multimorbidity with a mental disorder is little studied and is likely to have been affected by the COVID-19 pandemic. We used a survey of 14,007 respondents living in Brazil to investigate whether people who already had at least one chronic medical condition had more depression and anxiety symptoms during social distancing in 2020. Generalized linear models and structural equation modelling were used to estimate the effects. A 19 % and 15 % increase in depressive symptoms were found in females and males, respectively, for each unit of increase in the observed value of reported chronic disease. Older subjects presented fewer symptoms of depression and anxiety. There was a 16 % increase in anxiety symptoms in females for each unit increase in the reported chronic disease variable and a 14 % increase in males. Younger subjects were more affected by anxiety symptoms in a dose-response fashion. High income was significantly related to fewer depressive and anxiety symptoms in both males and females. Physical activity was significantly associated with fewer anxiety and depression symptoms. Structural equation modelling confirmed these results and provided further insight into the hypothesised paths

Current Landscape of Health Technologies in the Treatment of Antimicrobial Resistance: A Scope Review and Technological Prospecting

In the global public health scenario, antimicrobial resistance (AMR) is emerging as a growing and complex threat, becoming one of the most pressing issues facing contemporary society (LIMA et al., 2022). This phenomenon, which involves the ability of microorganisms to resist the effects of antimicrobials, seriously compromises the effectiveness of traditional treatments for a variety of infections (ALZAIN, 2020). AMR not only jeopardizes human life but also imposes significant economic challenges, straining healthcare systems and increasing public healthcare costs (SERRA-BURRIEL et al., 2020). Furthermore, AMR raises mortality and morbidity rates while undermining the effectiveness of preventive and therapeutic measures, leading to prolonged hospitalizations and increasing the complexity of treating common infectious diseases (WERNLI et al., 2020). As AMR continues to spread, driven by the widespread use of antimicrobials in humans, animals, and agriculture, as well as by globalization and climate change, it becomes imperative to explore innovative solutions (TANG et al., 2017). Global connectivity, coupled with the growing demand for food products, creates an ever-increasing societal dependence on the use of antimicrobials (PINNOCK et al., 2017). Ecological balance is disrupted, and antimicrobial susceptibility within the microbiome is threatened by pollutants (FOLKE, 2016). Addressing this challenge requires technological innovation, robust governance, sensible public policies, and practical practices, both at the national and global levels (ESPOSITO; DE SIMONE, 2017). In this context, the present review aims to map the healthcare technologies adopted to tackle AMR. In addition to investigating traditional interventions such as new antimicrobial agents and therapies, we will explore the latest innovations, including biosafety technologies and outbreak monitoring. By understanding existing technologies and identifying gaps, this review intends to provide a comprehensive overview of the current landscape. Our goal is not only to document scientific advancements but also to emphasize the urgent need for interdisciplinary collaboration and effective public policies to address this global health challenge

An outbreak of pyrogenic events connected with intravenous infusion devices in patients admitted to hospital São Paulo

Universidade Federal de São Paulo, Hosp Epidemiol Comm, Dept Infect Dis, São Paulo, BrazilUniversidade Federal de São Paulo, Infect Control & Prevent Comm, São Paulo, BrazilUniversidade Federal de São Paulo, Hosp Epidemiol Comm, Dept Infect Dis, São Paulo, BrazilUniversidade Federal de São Paulo, Infect Control & Prevent Comm, São Paulo, BrazilWeb of Scienc