Reconsidering research on teachers' professional identity

Wetensch. publicatieICLO

Multi-method triangulation in a qualitative study on teachers' practical knowledge: An attempt to increase internal validity

Wetensch. publicatieICLO

Duurzame maïsteelt op zandgrond : verslag van een deskundigendag, gehouden op 22 april 2010

Voor de melkveehouderij op zandgrond is de maïsteelt belangrijk. Zetmeelrijke, eiwitarme maïs combineert uitstekend met zetmeelarm maar eiwitrijk gras, wat goed is voor de koe maar ook voor het milieu omdat een maïsgewas zeer efficiënt met water omgaat en omdat een rantsoen met maïs de emissies van lachgas en ammoniak beperkt. Bovendien kan door de voeding van maïs op krachtvoer worden bespaard. Daar staat tegenover dat op veel bedrijven bij de maïsteelt te veel meststoffen en herbiciden naar het grond- en oppervlaktewater verloren gaan. Dat maakt het voor waterbeheerders moeilijk te voldoen aan de kwaliteitsnormen die de Kaderrichtlijn Water (KRW) stelt. Ook de maïstelers zijn daar niet blij mee, omdat dit duidt op een slechte benutting van grondstoffen. De teeltkosten zijn dan te hoog, de gewasopbrengsten te laag, of de bodemkwaliteit lijdt eronder

Cancer risk in DES daughters

We examined long-term risk of cancer in women exposed to diethylstilbestrol (DES) in utero. A total of 12,091 DES-exposed women in the Netherlands were followed prospectively from December 1992 till June 2008. Cancer incidence was assessed through linkage with the Dutch pathology database (PALGA) and the Netherlands Cancer Registry and compared with the Dutch female population. A total of 348 medically verified cancers occurred; median age at end of follow-up was 44.0 years. No overall increased risk of cancer was found (standardized incidence ratio [SIR] = 1.01; 95% confidence interval [CI] = 0.91, 1.13). The risk of clear cell adenocarcinoma of the vagina and cervix (CCA) was statistically significantly increased (SIR = 24.23; 95% CI = 8.89, 52.74); the elevated risk persisted above 40 years of age. The risk of melanoma diagnosed before age 40 was increased (SIR = 1.59; 95% CI = 1.08, 2.26). No excess risks were found for other sites, including breast cancer. Except for an elevated risk of CCA, persisting at older ages, and an increased risk of melanoma at young ages, we found no increased risk of cancer. Longer follow-up is warranted to examine cancer risk at ages when cancer occurs more frequently

Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United States

Although the association between in utero exposure to diethylstilbestrol (DES) and clear cell adenocarcinoma of the cervix and vagina (CCA) was first reported among young women, subsequent case reports and cohort studies suggest that an elevated risk for CCA may persist with age. Data from the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology and End Results (SEER) Program were used to construct indirect standardized incidence ratios (SIR) comparing CCA risk among women born during the exposure period 1947 through 1971, when DES was prescribed to pregnant women, to the relevant time period for nonexposed women born before or after DES exposure period. CCA incidence among the women born before the DES exposure period (ages 30–54 at diagnosis of CAA) or after the DES exposure period (ages 15–29 at diagnosis) were used to calculate the expected rates for women born during the DES exposure period. Among women aged 15–29 years, CCA risk increased with age and peaked in the 25–29 year age group, but the risk estimates were unstable (SIR = 6.06; 95% CI: 0.97, −251.07, SEER data). Among women aged 40–54 years, CCA risk was greatest in the 40–44 year age group (SIR = 4.55; 95% CI: 1.11, 40.19, SEER data and SIR = 3.94; 95% CI: 1.06, 33.01, NPCR/SEER data) and remained significantly elevated throughout this age group in the combined data set. Risk was not elevated among women aged 30–39 years. The observed risk of CCA, if causally related to DES exposure, reflects a persistent health impact from in utero exposure that is widespread in the general population. When assessing a woman’s cancer risks, whether her mother took DES while pregnant may still be a relevant aspect of the medical history for women born during the period of DES use in pregnancy