Relating the variability of tone-burst otoacoustic emission and auditory brainstem response latencies to the underlying cochlear mechanics

Forward and reverse cochlear latency and its relation to the frequency tuning of the auditory filters can be assessed using tone bursts (TBs). Otoacoustic emissions (TBOAEs) estimate the cochlear roundtrip time, while auditory brainstem responses (ABRs) to the same stimuli aim at measuring the auditory filter buildup time. Latency ratios are generally close to two and controversy exists about the relationship of this ratio to cochlear mechanics. We explored why the two methods provide different estimates of filter buildup time, and ratios with large inter-subject variability, using a time-domain model for OAEs and ABRs. We compared latencies for twenty models, in which all parameters but the cochlear irregularities responsible for reflection-source OAEs were identical, and found that TBOAE latencies were much more variable than ABR latencies. Multiple reflection-sources generated within the evoking stimulus bandwidth were found to shape the TBOAE envelope and complicate the interpretation of TBOAE latency and TBOAE/ABR ratios in terms of auditory filter tuning

Heating and thermal squeezing in parametrically-driven oscillators with added noise

In this paper we report a theoretical model based on Green functions, Floquet theory and averaging techniques up to second order that describes the dynamics of parametrically-driven oscillators with added thermal noise. Quantitative estimates for heating and quadrature thermal noise squeezing near and below the transition line of the first parametric instability zone of the oscillator are given. Furthermore, we give an intuitive explanation as to why heating and thermal squeezing occur. For small amplitudes of the parametric pump the Floquet multipliers are complex conjugate of each other with a constant magnitude. As the pump amplitude is increased past a threshold value in the stable zone near the first parametric instability, the two Floquet multipliers become real and have different magnitudes. This creates two different effective dissipation rates (one smaller and the other larger than the real dissipation rate) along the stable manifolds of the first-return Poincare map. We also show that the statistical average of the input power due to thermal noise is constant and independent of the pump amplitude and frequency. The combination of these effects cause most of heating and thermal squeezing. Very good agreement between analytical and numerical estimates of the thermal fluctuations is achieved.Comment: Submitted to Phys. Rev. E, 29 pages, 12 figures. arXiv admin note: substantial text overlap with arXiv:1108.484

A metaphor for adiabatic evolution to symmetry

In this paper we study a Hamiltonian system with a spatially asymmetric potential. We are interested in the effects on the dynamics when the potential becomes symmetric slowly in time. We focus on a highly simplified non-trivial model problem (a metaphor) to be able to pursue explicit calculations as far as possible. Using the techniques of averaging and adiabatic invariants, we are able to study all bounded solutions, which reveals significant asymmetric dynamics even when the asymmetric contributions to the potential have become negligibly small.Comment: 27 pages, LaTeX 2e, 8 figures include

A mechanism for pair formation in strongly correlated systems

We start from a Hamiltonian describing non-interacting fermions and add bosons to the model, with a Jaynes-Cummings-like interaction between the bosons and fermions. Because of the specific form of the interaction the model can be solved exactly. In the ground state, part of the electrons form bound pairs with opposite momentum and spin. The model also shows a gap in the kinetic energy of the fermions, but not in the spectrum of the full Hamiltonian. This gap is not of a mean-field nature, but is due to the Pauli exclusion principle.Comment: 13 pages, corrected some notations and made some clarification

Substance Use and Depression Symptomatology: Measurement Invariance of the Beck Depression Inventory (BDI-II) among Non-Users and Frequent-Users of Alcohol, Nicotine and Cannabis

Depression is a highly heterogeneous condition, and identifying how symptoms present in various groups may greatly increase our understanding of its etiology. Importantly, Major Depressive Disorder is strongly linked with Substance Use Disorders, which may ameliorate or exacerbate specific depression symptoms. It is therefore quite plausible that depression may present with different symptom profiles depending on an individual’s substance use status. Given these observations, it is important to examine the underlying construct of depression in groups of substance users compared to non-users. In this study we use a non-clinical sample to examine the measurement structure of the Beck Depression Inventory (BDI-II) in non-users and frequent-users of various substances. Specifically, measurement invariance was examined across those who do vs. do not use alcohol, nicotine, and cannabis. Results indicate strict factorial invariance across non-users and frequent-users of alcohol and cannabis, and metric invariance across non-users and frequent-users of nicotine. This implies that the factor structure of the BDI-II is similar across all substance use groups

Bifurcation analysis of a normal form for excitable media: Are stable dynamical alternans on a ring possible?

We present a bifurcation analysis of a normal form for travelling waves in one-dimensional excitable media. The normal form which has been recently proposed on phenomenological grounds is given in form of a differential delay equation. The normal form exhibits a symmetry preserving Hopf bifurcation which may coalesce with a saddle-node in a Bogdanov-Takens point, and a symmetry breaking spatially inhomogeneous pitchfork bifurcation. We study here the Hopf bifurcation for the propagation of a single pulse in a ring by means of a center manifold reduction, and for a wave train by means of a multiscale analysis leading to a real Ginzburg-Landau equation as the corresponding amplitude equation. Both, the center manifold reduction and the multiscale analysis show that the Hopf bifurcation is always subcritical independent of the parameters. This may have links to cardiac alternans which have so far been believed to be stable oscillations emanating from a supercritical bifurcation. We discuss the implications for cardiac alternans and revisit the instability in some excitable media where the oscillations had been believed to be stable. In particular, we show that our condition for the onset of the Hopf bifurcation coincides with the well known restitution condition for cardiac alternans.Comment: to be published in Chao

Entanglement of a microcanonical ensemble

We replace time-averaged entanglement by ensemble-averaged entanglement and derive a simple expression for the latter. We show how to calculate the ensemble average for a two-spin system and for the Jaynes-Cummings model. In both cases the time-dependent entanglement is known as well so that one can verify that the time average coincides with the ensemble average.Comment: 10 page

Which better predicts conduct problems? The relationship of trajectories of Conduct Problems, with ODD and ADHD Symptoms from childhood into adolescence

Background: To assess the co-occurrence in deviant trajectories of parent-rated symptoms of conduct disorder (CD), oppositional defiant disorder (ODD) and attention-deficit/hyperactivity disorder (ADHD) from age 4 to 18 years old in a general population sample of Dutch children. Methods: Developmental trajectories of CD, ODD, and ADHD were estimatedin a sample of 1,016 males and 1,060 females. Children's disruptive problem behaviors were rated at 5 time-points. The co-occurrence patterns between the deviant CD trajectory, and the high ODD and high ADHD trajectory were studied for males and females separately. Results: Four percent of males and 2% of females followed a deviant CD trajectory. Six percent of the sample followed a high ODD trajectory, and 5% a high ADHD trajectory. Engagement in the deviant CD trajectory was predicted by ODD and ADHD in females, but only by ODD in males. Conclusions: Although ADHD co-occurs with CD, the association between ADHD and CD is largely accounted for by accompanying ODD. Gender differences should be taken into account in understanding the onset of CD. © 2007 The Authors Journal compilation © 2007 Association for Child and Adolescent Mental Health

Effect of ambient temperature during acute aerobic exercise on short-term appetite, energy intake, and plasma acylated ghrelin in recreationally active males

Ambient temperature during exercise may affect energy intake regulation. Compared with a temperate (20 °C) environment, 1 h of running followed by 6 h of rest tended to decrease energy intake from 2 ad libitum meals in a hot (30 °C) environment but increase energy intake in a cool (10 °C) environment (p = 0.08). Core temperature changes did not appear to mediate this trend; whether acylated ghrelin is involved is unclear. Further research is warranted to clarify these findings