168 research outputs found
Accelerated respiratory-resolved 4D-MRI with separable spatio-temporal neural networks
Background: Respiratory-resolved four-dimensional magnetic resonance imaging
(4D-MRI) provides essential motion information for accurate radiation
treatments of mobile tumors. However, obtaining high-quality 4D-MRI suffers
from long acquisition and reconstruction times.
Purpose: To develop a deep learning architecture to quickly acquire and
reconstruct high-quality 4D-MRI, enabling accurate motion quantification for
MRI-guided radiotherapy.
Methods: A small convolutional neural network called MODEST is proposed to
reconstruct 4D-MRI by performing a spatial and temporal decomposition, omitting
the need for 4D convolutions to use all the spatio-temporal information present
in 4D-MRI. This network is trained on undersampled 4D-MRI after respiratory
binning to reconstruct high-quality 4D-MRI obtained by compressed sensing
reconstruction. The network is trained, validated, and tested on 4D-MRI of 28
lung cancer patients acquired with a T1-weighted golden-angle radial
stack-of-stars sequence. The 4D-MRI of 18, 5, and 5 patients were used for
training, validation, and testing. Network performances are evaluated on image
quality measured by the structural similarity index (SSIM) and motion
consistency by comparing the position of the lung-liver interface on
undersampled 4D-MRI before and after respiratory binning. The network is
compared to conventional architectures such as a U-Net, which has 30 times more
trainable parameters.
Results: MODEST can reconstruct high-quality 4D-MRI with higher image quality
than a U-Net, despite a thirty-fold reduction in trainable parameters.
High-quality 4D-MRI can be obtained using MODEST in approximately 2.5 minutes,
including acquisition, processing, and reconstruction.
Conclusion: High-quality accelerated 4D-MRI can be obtained using MODEST,
which is particularly interesting for MRI-guided radiotherapy.Comment: Code available at https://gitlab.com/computational-imaging-lab/modes
Exploring contrast generalisation in deep learning-based brain MRI-to-CT synthesis
Background: Synthetic computed tomography (sCT) has been proposed and
increasingly clinically adopted to enable magnetic resonance imaging
(MRI)-based radiotherapy. Deep learning (DL) has recently demonstrated the
ability to generate accurate sCT from fixed MRI acquisitions. However, MRI
protocols may change over time or differ between centres resulting in
low-quality sCT due to poor model generalisation. Purpose: investigating domain
randomisation (DR) to increase the generalisation of a DL model for brain sCT
generation. Methods: CT and corresponding T1-weighted MRI with/without
contrast, T2-weighted, and FLAIR MRI from 95 patients undergoing RT were
collected, considering FLAIR the unseen sequence where to investigate
generalisation. A ``Baseline'' generative adversarial network was trained
with/without the FLAIR sequence to test how a model performs without DR. Image
similarity and accuracy of sCT-based dose plans were assessed against CT to
select the best-performing DR approach against the Baseline. Results: The
Baseline model had the poorest performance on FLAIR, with mean absolute error
(MAE)=10620.7 HU (mean). Performance on FLAIR significantly
improved for the DR model with MAE=99.014.9 HU, but still inferior to the
performance of the Baseline+FLAIR model (MAE=72.610.1 HU). Similarly, an
improvement in -pass rate was obtained for DR vs Baseline. Conclusions:
DR improved image similarity and dose accuracy on the unseen sequence compared
to training only on acquired MRI. DR makes the model more robust, reducing the
need for re-training when applying a model on sequences unseen and unavailable
for retraining.Comment: Preprint submitted to Physica Medica on 2023-02-16 for review. Also
published in Zenodo at https://doi.org/10.5281/zenodo.774264
Efficacy of stereotactic ablative radiotherapy (SABR) during anti-PD-1 in oligoprogressive non-small cell lung cancer and melanoma-a prospective multicenter observational study pointing out new unmet needs
Radiotherapy Late Effects and Osteogenesis Imperfecta: Dos and Don’ts in Clinical Practice
In radiation oncology, little is known about possible difficulties in patients with Osteogenesis Imperfecta (OI). Because radiotherapy can cause various side-effects including bone, soft tissue and cardiovascular toxicities, we foresee that patients with OI may experience even more acute and late side-effects due to pre-existing problems. We present two cases of radiotherapy in patients with OI, measured the effects of radiation on their bone mineral density and provide clinical recommendations for patient tailored radiotherapy strategies in patients with OI
Accelerated respiratory-resolved 4D-MRI with separable spatio-temporal neural networks
Background: Respiratory-resolved four-dimensional magnetic resonance imaging (4D-MRI) provides essential motion information for accurate radiation treatments of mobile tumors. However, obtaining high-quality 4D-MRI suffers from long acquisition and reconstruction times. Purpose: To develop a deep learning architecture to quickly acquire and reconstruct high-quality 4D-MRI, enabling accurate motion quantification for MRI-guided radiotherapy (MRIgRT). Methods: A small convolutional neural network called MODEST is proposed to reconstruct 4D-MRI by performing a spatial and temporal decomposition, omitting the need for 4D convolutions to use all the spatio-temporal information present in 4D-MRI. This network is trained on undersampled 4D-MRI after respiratory binning to reconstruct high-quality 4D-MRI obtained by compressed sensing reconstruction. The network is trained, validated, and tested on 4D-MRI of 28 lung cancer patients acquired with a T1-weighted golden-angle radial stack-of-stars (GA-SOS) sequence. The 4D-MRI of 18, 5, and 5 patients were used for training, validation, and testing. Network performances are evaluated on image quality measured by the structural similarity index (SSIM) and motion consistency by comparing the position of the lung-liver interface on undersampled 4D-MRI before and after respiratory binning. The network is compared to conventional architectures such as a U-Net, which has 30 times more trainable parameters. Results: MODEST can reconstruct high-quality 4D-MRI with higher image quality than a U-Net, despite a thirty-fold reduction in trainable parameters. High-quality 4D-MRI can be obtained using MODEST in approximately 2.5 min, including acquisition, processing, and reconstruction. Conclusion: High-quality accelerated 4D-MRI can be obtained using MODEST, which is particularly interesting for MRIgRT
Exploring contrast generalisation in deep learning-based brain MRI-to-CT synthesis
BACKGROUND: Synthetic computed tomography (sCT) has been proposed and increasingly clinically adopted to enable magnetic resonance imaging (MRI)-based radiotherapy. Deep learning (DL) has recently demonstrated the ability to generate accurate sCT from fixed MRI acquisitions. However, MRI protocols may change over time or differ between centres resulting in low-quality sCT due to poor model generalisation. PURPOSE: investigating domain randomisation (DR) to increase the generalisation of a DL model for brain sCT generation. METHODS: CT and corresponding T 1-weighted MRI with/without contrast, T 2-weighted, and FLAIR MRI from 95 patients undergoing RT were collected, considering FLAIR the unseen sequence where to investigate generalisation. A "Baseline" generative adversarial network was trained with/without the FLAIR sequence to test how a model performs without DR. Image similarity and accuracy of sCT-based dose plans were assessed against CT to select the best-performing DR approach against the Baseline. RESULTS: The Baseline model had the poorest performance on FLAIR, with mean absolute error (MAE) = 106 ± 20.7 HU (mean ±σ). Performance on FLAIR significantly improved for the DR model with MAE = 99.0 ± 14.9 HU, but still inferior to the performance of the Baseline+FLAIR model (MAE = 72.6 ± 10.1 HU). Similarly, an improvement in γ-pass rate was obtained for DR vs Baseline. CONCLUSION: DR improved image similarity and dose accuracy on the unseen sequence compared to training only on acquired MRI. DR makes the model more robust, reducing the need for re-training when applying a model on sequences unseen and unavailable for retraining
Real-time 3D motion estimation from undersampled MRI using multi-resolution neural networks
Purpose: To enable real-time adaptive magnetic resonance imaging–guided radiotherapy (MRIgRT) by obtaining time-resolved three-dimensional (3D) deformation vector fields (DVFs) with high spatiotemporal resolution and low latency ((Formula presented.) ms). Theory and Methods: Respiratory-resolved (Formula presented.) -weighted 4D-MRI of 27 patients with lung cancer were acquired using a golden-angle radial stack-of-stars readout. A multiresolution convolutional neural network (CNN) called TEMPEST was trained on up to 32 (Formula presented.) retrospectively undersampled MRI of 17 patients, reconstructed with a nonuniform fast Fourier transform, to learn optical flow DVFs. TEMPEST was validated using 4D respiratory-resolved MRI, a digital phantom, and a physical motion phantom. The time-resolved motion estimation was evaluated in-vivo using two volunteer scans, acquired on a hybrid MR-scanner with integrated linear accelerator. Finally, we evaluated the model robustness on a publicly-available four-dimensional computed tomography (4D-CT) dataset. Results: TEMPEST produced accurate DVFs on respiratory-resolved MRI at 20-fold acceleration, with the average end-point-error (Formula presented.) mm, both on respiratory-sorted MRI and on a digital phantom. TEMPEST estimated accurate time-resolved DVFs on MRI of a motion phantom, with an error (Formula presented.) mm at 28 (Formula presented.) undersampling. On two volunteer scans, TEMPEST accurately estimated motion compared to the self-navigation signal using 50 spokes per dynamic (366 (Formula presented.) undersampling). At this undersampling factor, DVFs were estimated within 200 ms, including MRI acquisition. On fully sampled CT data, we achieved a target registration error of (Formula presented.) mm without retraining the model. Conclusion: A CNN trained on undersampled MRI produced accurate 3D DVFs with high spatiotemporal resolution for MRIgRT
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