Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials

The available evidence supports first-line treatment of lower urinary tract infections with nitrofurantoin as clinical efficacy is similar to that seen for trimethoprim/sulfamethoxazole, ciprofloxacin and amoxicillin, rates of microbiological cure are good, short- term toxicity is generally mild and acquired resistance is still relatively rar

Nitrofurantoin's efficacy and safety as prophylaxis for urinary tract infections: a systematic review of the literature and meta-analysis of controlled trials

Nitrofurantoin has been used for the prevention of urinary tract infection (UTI) for over 60 years. We conducted a systematic review and meta-analysis to assess nitrofurantoin's efficacy and safety in the prophylaxis of UTI