Nucleon excited states on the lattice

We study the pion-nucleon system in s-wave in the framework of lattice QCD in order to gain new information on the nucleon excited states. We perform simulations for $n_f =2$ mass degenerate light quarks at a pion mass of 266 MeV. The results show that including the two-particle states drastically changes the energy levels. The variational analysis and the distillation approach play an important role in the extraction of the energy levels. The phase shift analysis allows to extract information on the resonance nature of the observed states.Comment: 6 pages, 2 figures, talk presented at Excited QCD 2013, Bjelasnica Mountain, Sarajev

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

Aim: The p53 cancer mutation Y220C creates a conformationally unstable protein with a unique elongated surface crevice that can be targeted by molecular chaperones. We report the structure-guided optimization of the carbazole-based stabilizer PK083. Materials & methods: Biophysical, cellular and x-ray crystallographic techniques have been employed to elucidate the mode of action of the carbazole scaffolds. Results: Targeting an unoccupied subsite of the surface crevice with heterocycle-substituted PK083 analogs resulted in a 70-fold affinity increase to single-digit micromolar levels, increased thermal stability and decreased rate of aggregation of the mutant protein. PK9318, one of the most potent binders, restored p53 signaling in the liver cancer cell line HUH-7 with homozygous Y220C mutation. Conclusion: The p53-Y220C mutant is an excellent paradigm for the development of mutant p53 rescue drugs via protein stabilization. Similar rescue strategies may be applicable to other cavity-creating p53 cancer mutations

EDUCATION Elementary and Secondary Education: Authorize the Reading or Posting of Certain Writings, Documents, and Records Without Content-Based Censorship Thereof; Provide for Notice to Local School Superintendents; and for Other Purposes

The bill would have permitted state school boards to allow and encourage their teachers and administrators to read or post in their school building, classrooms, or at any event, documents or any portion of documents that relate to American heritage. The bill would have provided a list of documents, including the Constitution, the Declaration of Independence, the Mayflower Compact, and United States Supreme Court decisions. The bill would have prohibited content-based censorship of American history and heritage-based documents regarding any religious references

EDUCATION Elementary and Secondary Education: Authorize the Reading or Posting of Certain Writings, Documents, and Records Without Content-Based Censorship Thereof; Provide for Notice to Local School Superintendents; and for Other Purposes

The bill would have permitted state school boards to allow and encourage their teachers and administrators to read or post in their school building, classrooms, or at any event, documents or any portion of documents that relate to American heritage. The bill would have provided a list of documents, including the Constitution, the Declaration of Independence, the Mayflower Compact, and United States Supreme Court decisions. The bill would have prohibited content-based censorship of American history and heritage-based documents regarding any religious references