Geographic variation in the sensitivity of recombinant antigen-based rapid tests for chronic trypanosoma cruzi infection

Chagas disease affects 8-11 million people throughout the Americas. Early detection is crucial for timely treatment and to prevent non-vectorial transmission. Recombinant antigen-based rapid tests had high sensitivity and specificity in laboratory evaluations, but no Peruvian specimens were included in previous studies. We evaluated Stat-Pak and Trypanosoma Detect rapid tests in specimens from Bolivia and Peru. Specimens positive by three conventional assays were confirmed positives; specimens negative by two or more assays were confirmed negatives. In Bolivian specimens, Stat-Pak and Trypanosoma Detect tests were 87.5% and 90.7% sensitive, respectively; both showed 100% specificity. Sensitivity in Peruvian specimens was much lower: 26.6-33.0% (Stat-Pak) and 54.3-55.2% (Trypanosoma Detect); both had specificities > 98%. Even in Bolivian specimens, these sensitivities are inadequate for stand-alone screening. The low sensitivity in Peru may be related to parasite strain differences. Chagas disease rapid tests should be field tested in each geographic site before widespread implementation for screening. Copyrigh

Meteoroids as One of the Sources for Exosphere Formation on Airless Bodies in the Inner Solar System

AbstractThis manuscript represents a review on progress made over the past decade concerning our understanding of meteoroid bombardment on airless solar system bodies as one of the sources of the formation of their exospheres. Specifically, observations at Mercury by MESSENGER and at the Moon by LADEE, together with progress made in dynamical models of the meteoroid environment in the inner solar system, offer new tools to explore in detail the physical phenomena involved in this complex relationship. This progress is timely given the expected results during the next decade that will be provided by new missions such as DESTINY+, BepiColombo, the Artemis program or the Lunar Gateway