Efectividad de la comunicación en redes sociales de universidades líderes

The article presents the results of communication effectiveness analysis in social networks of leading universities with strong economic departments. The study was carried out using the textual information analysis i.e. content, links, posts, comments, tags, etc.; multimedia i.e. photos, videos, audio, etc., and the ontology method, which estimated the social networks parameters like the number of subscribers, average path length, etc. The study showed that the main platform for international higher education institutions is Facebook; Instagram is actively developing, and then comes YouTube. The number of publications does not directly affect the number of subscribers, in contrast to the number of students. The high frequency of posts does not lead to subscribers increase. There is no single strategy for universities social network development. The use of informal communication, which encourages action, significantly increases the audience and its involvement; but is not used by all universities, because it might contradict with the university’s image. It should be noted that good design, the use of professional photos and videos, has its impact on potential audience.El artículo presenta los resultados del análisis de la efectividad de la comunicación en las redes sociales en las principales universidades con departamentos económicos sólidos. El estudio se llevó a cabo utilizando el análisis de información textual, es decir, contenido, enlaces, publicaciones, comentarios, etiquetas, etc .; multimedia, es decir, fotos, videos, audio, etc., y el método ontológico, que estimó los parámetros de las redes sociales como el número de suscriptores, la longitud promedio de la ruta, etc. El estudio mostró que la principal plataforma para las instituciones internacionales de educación superior es Facebook; Instagram se está desarrollando activamente y luego viene YouTube. El número de publicaciones no afecta directamente al número de suscriptores, a diferencia del número de estudiantes. La alta frecuencia de publicaciones no conduce a un aumento de suscriptores. No existe una estrategia única para el desarrollo de redes sociales de las universidades. El uso de la comunicación informal, que fomenta la acción, aumenta significativamente la audiencia y su participación; pero no es utilizado por todas las universidades, porque podría resultar contrario a la imagen de la universidad. Cabe señalar que un buen diseño, el uso de fotos y videos profesionales, tiene su impacto en la audiencia potencial

Communication effectiveness in social networks of leading universities

The article presents the results of communication effectiveness analysis in social networks of leading universities with strong economic departments. The study was carried out using the textual information analysis i.e. content, links, posts, comments, tags, etc.; multimedia i.e. photos, videos, audio, etc., and the ontology method, which estimated the social networks parameters like the number of subscribers, average path length, etc.The study showed that the main platform for international higher education institutions is Facebook; Instagram is actively developing, and then comes YouTube. The number of publications does not directly affect the number of subscribers, in contrast to the number of students. The high frequency of posts does not lead to subscribers increase. There is no single strategy for universities social network development. The use of informal communication, which encourages action, significantly increases the audience and its involvement; but is not used by all universities, because it might contradict with the university’s image. It should be noted that good design, the use of professional photos and videos, has its impact on potential audience

Innovative market research functions

The relevance of the article lies in the discussion of the marketing strategy and success of companies that have achieved world fame. The purpose of the work is to conduct an assessment of the company's activities, as well as to show how, using elements of marketing, you can achieve tremendous success. The task of the study is to study the market, the proper organisation of fast food, and the study of the psychology of people. The results of the research will allow managers of organizations to increase the efficiency of using human capital. The novelty of the development is determined, in our opinion, on the one hand, by the methodological approach to the correlation of many existing versions of the interpretation of this problem. Also, within each direction, the corresponding concepts are defined, on which they are based, and which, in turn, reflect the real prerequisites for the diversity of versions in the past and present. It is known that marketing is a continuous process in which goals change: when one is achieved, a new one is set. Here, it is of no small importance to involve children and adolescents in the use of hamburgers through the organisation of playgrounds, family trips and food sets for children with toys

Listeria monocytogenes meningoencephalitis against the background of the new coronavirus infection: a clinical case

Background: Among the bacteria that affect the central nervous system, Listeria monocytogenes (facultative intracellular bacterium) is one of the most lethal to humans and animals. Listeriosis affects domestic and farm animals (pigs, small and large cattle, horses, rabbits, less often cats and dogs), as well as domestic and ornamental birds (geese, chickens, ducks, turkeys, pigeons, parrots and canaries). L. monocytogenes can be detected in fish and seafood (shrimp). The source of L. monocytogenes infection are animals in which the disease may manifest itself or occur in erased and asymptomatic forms followed by the transition to a long-term carriage. This pathogen is found throughout the world in foodstuffs, and most cases of infection occur through the ingestion of contaminated food. Particularly susceptible to the disease are embryos, newborns, the elderly and individuals with immunodeficiencies and chronic diseases. L. monocytogenes can cause intracranial hemorrhage, meningitis, meningoencephalitis, and rhombencephalitis. Clinical case description: This paper presents our own clinical observation of the development of severe listeriosis meningoencephalitis in a 47 year-old patient against the background of the new coronavirus infection (COVID-19). We describe the details of the clinical presentation, the treatment and the favorable outcome in our patient. Conclusion: Invasive listeriosis is a rare disease. The knowledge about the clinical manifestations of this disease is needed not only for epidemiologists and infectious disease specialists, but also for physicians of other specialties. Untimely diagnosis and inadequate antibacterial therapy are dangerous leading to severe somatic and neurological complications with a lethal outcome or disability both in children and adult persons

Innovative market research functions

The relevance of the article lies in the discussion of the marketing strategy and success of companies that have achieved world fame. The purpose of the work is to conduct an assessment of the company's activities, as well as to show how, using elements of marketing, you can achieve tremendous success. The task of the study is to study the market, the proper organisation of fast food, and the study of the psychology of people. The results of the research will allow managers of organizations to increase the efficiency of using human capital. The novelty of the development is determined, in our opinion, on the one hand, by the methodological approach to the correlation of many existing versions of the interpretation of this problem. Also, within each direction, the corresponding concepts are defined, on which they are based, and which, in turn, reflect the real prerequisites for the diversity of versions in the past and present. It is known that marketing is a continuous process in which goals change: when one is achieved, a new one is set. Here, it is of no small importance to involve children and adolescents in the use of hamburgers through the organisation of playgrounds, family trips and food sets for children with toys

The Institution of hmw-k' in Ancient Egypt of the Middle Kingdom

Статья посвящена рассмотрению института "заупокойных жрецов" в Египте эпохи Среднего Царства. Данный институт долгое время являлся существенным элементом как социальной, так и экономической структуры египетского общества, претерпевая существенные изменения во времени. В настоящее время лучше всего известна форма, присущая этому виду духовно-практической деятельности в эпоху Старого царства, благодаря сравнительно большому числу источников и наличию ряда исследований. Гораздо хуже известна его среднецарская форма, которая и составляет предмет наблюдения в данной статье

Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein

The relationship between altered metabolism of the amyloid-β precursor protein (APP) and Alzheimer's disease is well established but the physiological roles of APP still remain unclear. Here, we studied Ca2+ signaling in primary cultured and freshly dissociated cortical astrocytes from APP knockout (KO) mice and from Tg5469 mice overproducing by five- to sixfold wild-type APP. Resting cytosolic Ca2+ (measured with fura-2) was not altered in cultured astrocytes from APP KO mice. The stored Ca2+ evaluated by measuring peak amplitude of cyclopiazonic acid [CPA, endoplasmic reticulum (ER) Ca2+ ATPase inhibitor]-induced Ca2+ transients in Ca2+-free medium was significantly smaller in APP KO astrocytes than in wild-type cells. Store-operated Ca2+ entry (SOCE) activated by ER Ca2+ store depletion with CPA was also greatly reduced in APP KO astrocytes. This reflected a downregulated expression in APP KO astrocytes of TRPC1 (C-type transient receptor potential) and Orai1 proteins, essential components of store-operated channels (SOCs). Indeed, silencer RNA (siRNA) knockdown of Orai1 protein expression in wild-type astrocytes significantly attenuated SOCE. SOCE was also essentially reduced in freshly dissociated APP KO astrocytes. Importantly, knockdown of APP with siRNA in cultured wild-type astrocytes markedly attenuated ATP- and CPA-induced ER Ca2+ release and extracellular Ca2+ influx. The latter correlated with downregulation of TRPC1. Overproduction of APP in Tg5469 mice did not alter, however, the stored Ca2+ level, SOCE, and expression of TRPC1/4/5 in cultured astrocytes from these mice. The data demonstrate that the functional role of APP in astrocytes involves the regulation of TRPC1/Orai1-encoded SOCs critical for Ca2+ signaling

Ca2+ handling is altered when arterial myocytes progress from a contractile to a proliferative phenotype in culture

Phenotypic modulation of vascular myocytes is important for vascular development and adaptation. A characteristic feature of this process is alteration in intracellular Ca2+ handling, which is not completely understood. We studied mechanisms involved in functional changes of inositol 1,4,5-trisphosphate (IP3)- and ryanodine (Ry)-sensitive Ca2+ stores, store-operated Ca2+ entry (SOCE), and receptor-operated Ca2+ entry (ROCE) associated with arterial myocyte modulation from a contractile to a proliferative phenotype in culture. Proliferating, cultured myocytes from rat mesenteric artery have elevated resting cytosolic Ca2+ levels and increased IP3-sensitive Ca2+ store content. ATP- and cyclopiazonic acid [CPA; a sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) inhibitor]-induced Ca2+ transients in Ca2+-free medium are significantly larger in proliferating arterial smooth muscle cells (ASMCs) than in freshly dissociated myocytes, whereas caffeine (Caf)-induced Ca2+ release is much smaller. Moreover, the Caf/Ry-sensitive store gradually loses sensitivity to Caf activation during cell culture. These changes can be explained by increased expression of all three IP3 receptors and a switch from Ry receptor type II to type III expression during proliferation. SOCE, activated by depletion of the IP3/CPA-sensitive store, is greatly increased in proliferating ASMCs. Augmented SOCE and ROCE (activated by the diacylglycerol analog 1-oleoyl-2-acetyl-sn-glycerol) in proliferating myocytes can be attributed to upregulated expression of, respectively, transient receptor potential proteins TRPC1/4/5 and TRPC3/6. Moreover, stromal interacting molecule 1 (STIM1) and Orai proteins are upregulated in proliferating cells. Increased expression of IP3 receptors, SERCA2b, TRPCs, Orai(s), and STIM1 in proliferating ASMCs suggests that these proteins play a critical role in an altered Ca2+ handling that occurs during vascular growth and remodeling