Massive young stellar objects in the N66/NGC346 region of the SMC

We present HK spectra of three sources located in the N66 region of the Small Magellanic Cloud. The sources display prominent stellar Br Gamma and extended H2 emission, and exhibit infrared excesses at lambda > 2 micron. Based on their spectral features, and photometric spectral energy distributions, we suggest that these sources are massive young stellar objects (mYSOs). The findings are interpreted as evidence of on-going high mass star formation in N66.Comment: Accepted for publication on Astronomy and Astrophysics Journal, acceptance date 21/03/2018 (includes 12 pages, 5 figures

An Image Indexing and Region based on Color and Texture

From the previous decade, the enormous rise of the internet has tremendously maximized the amount image databases obtainable. This image gathering such as art works, satellite and medicine is fascinating ever more customers in numerous application domains. The work on image retrieval primarily focuses on efficient and effective relevant images from huge and varied image gatherings which is further becoming more fascinating and exciting. In this paper, the author suggested an effective approach for approximating large-scale retrieval of images through indexing. This approach primarily depends on the visual content of the image segment where the segments are obtained through fuzzy segmentation and are demonstrated through high-frequency sub-band wavelets. Furthermore, owing to the complexity in monitoring large scale information and exponential growth of the processing time, approximate nearest neighbor algorithm is employed to enhance the retrieval speed. Thus, a locality-sensitive hashing using (K-NN Algorithm) is adopted for region-aided indexing technique. Particularly, as the performance of K-NN Approach hinges essentially on the hash function segregating the space, a novel function was uncovered motivated using E8 lattice which could efficiently be amalgamated with multiple probes K-NN Approach and query-adaptive K- NN Approach. To validate the adopted hypothetical selections and to enlighten the efficiency of the suggested approach, a group of experimental results associated to the region-based image retrieval is carried out on the COREL data samples

Prospective study on vacuum assisted closure therapy in treatment of soft tissue injuries associated with Gustilo Anderson compound Grade IIIB fractures

BACK GROUND: The Primary objective of this prospective study is to study the rate of infection, number of days required for formation of healthy granulation tissue, healing of soft tissue injury and number of days of hospital stay and cost effectiveness associated with Gustilo Anderson compound grade IIIb fractures treated by Vacuum Assisted closure therapy. METHODS: Seventeen patients with Type IIIb open fractures were included in this study..All these patients had undergone wound debridement and fracture fixation. This wss followed by application of Vacuum Assisted Closure (VAC) The infection rate analysed by clinical findings and investigations. RESULTS: The infection rate was low when compared to literature study of conventional dressings. The primary wound coverage can be done earlier wound healing was also faster in patients. CONCLUSION: This is a simple and low cost method for treating soft tissue injury associated with severe open fractures. It can be done even in peripheral hospitals with low resources

UML Modeling for Tea / Coffee Machine

Unified Modeling language (UML) is one of the important modeling languages used for the visual representation of the research problem. In the present paper, UML model is designed for the Tea / Coffee Machine which is used for the purpose of the public in the hotels or restaurants2019;. The class and use case diagrams are designe

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer

Purpose: DEAD box protein 3 (DDX3) is an RNA helicase with oncogenic properties that shuttles between the cytoplasm and nucleus. The majority of DDX3 is found in the cytoplasm, but a subset of tumors has distinct nuclear DDX3 localization of yet unknown biological significance. This study aimed to evaluate the significance of and mechanisms behind nuclear DDX3 expression in colorectal and breast cancer. Methods: Expression of nuclear DDX3 and the nuclear exporter chromosome region maintenance 1 (CRM1) was evaluated by immunohistochemistry in 304 colorectal and 292 breast cancer patient samples. Correlations between the subcellular localization of DDX3 and CRM1 and the difference in overall survival between patients with and without nuclear DDX3 were studied. In addition, DDX3 mutants were created for in vitro evaluation of the mechanism behind nuclear retention of DDX3. Results: DDX3 was present in the nucleus of 35% of colorectal and 48% of breast cancer patient samples and was particularly strong in the nucleolus. Nuclear DDX3 correlated with worse overall survival in both colorectal (hazard ratio [HR] 2.34, P<0.001) and breast cancer (HR 2.39, P=0.004) patients. Colorectal cancers with nuclear DDX3 expression more often had cytoplasmic expression of the nuclear exporter CRM1 (relative risk 1.67, P=0.04). In vitro analysis of DDX3 deletion mutants demonstrated that CRM1-mediated export was most dependent on the N-terminal nuclear export signal. Conclusion: Overall, we conclude that nuclear DDX3 is partially CRM1-mediated and predicts worse survival in colorectal and breast cancer patients, putting it forward as a target for therapeutic intervention with DDX3 inhibitors under development in these cancer types

Structural and reactivity analyses of nitrofurantoin 4 dimethylaminopyridine salt using spectroscopic and density functional theory calculations

YesPharmaceutical salt, nitrofurantoin–4-dimethylaminopyridine (NF-DMAP), along with its native components NF and DMAP are scrutinized by FT-IR and FT-Raman spectroscopy along with density functional theory so that an insight into the H-bond patterns in the respective crystalline lattices can be gained. Two different functionals, B3LYP and wB97X-D, have been used to compare the theoretical results. The FT-IR spectra obtained for NF-DMAP and NF clearly validate the presence of C33–H34⋅⋅⋅O4 and N23–H24⋅⋅⋅N9 hydrogen bonds by shifting in the stretching vibration of –NH and –CH group of DMAP+ towards the lower wavenumber side. To explore the significance of hydrogen bonding, quantum theory of atoms in molecules (QTAIM) has been employed, and the findings suggest that the N23–H24⋅⋅⋅N9 bond is a strong intermolecular hydrogen bond. The decrement in the HOMO-LUMO gap, which is calculated from NF → NF-DMAP, reveals that the active pharmaceutical ingredient is chemically less reactive compared to the salt. The electrophilicity index (ω) profiles for NF and DMAP confirms that NF is acting as electron acceptor while DMAP acts as electron donor. The reactive sites of the salt are plotted by molecular electrostatic potential (MEP) surface and calculated using local reactivity descriptors.SERB, DST, India, for providing the National Post-doctoral Fellowship (Project File Number: PDF/2016/003162); Central Facility for Computational Research (CFCR), University of Lucknow; Newton-Bhabha Ph.D. placement award (2017); Royal Society seed corn research grant (2018-19

Thermal and in situ x-ray diffraction analysis of a dimorphic co-crystal 1:1 caffeine-glutaric acid

YesSpurred by the enormous interest in co-crystals from the pharmaceutical industry, many novel co-crystals of active pharmaceutical ingredients have been discovered in recent years and this has in turn led to an increasing number of reports on polymorphs of co-crystals. Hence, a thorough characterization and understanding of co-crystal polymorphs is a valuable step during drug development. The purpose of this study is to perform in situ structural analysis and to determine thermodynamic stability of a dimorphic co-crystal system, 1:1 caffeine-glutaric acid (CA-GA, Forms I and II). We performed thermal and structural characterizations by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), hot-stage microscopy (HSM), slurry and in situ variable temperature X-ray diffraction (VTXRD). For completeness, we have also re-determined crystal structures of CA-GA Forms I and II at 180 K using single crystal X-ray diffraction. Our results revealed that Form II is stable and Form I is metastable at ambient conditions. Further, the results suggest that the dimorphs are enantiotropically related and the transition temperature is estimated to be 79 Celcius degrees.This work was supported by Science and Engineering Research Council of A*STAR (Agency for Science, Technology and Research), Singapore

Nitro­furan­toin methanol monosolvate

The anti­biotic nitro­furan­toin {systematic name: (E)-1-[(5-nitro-2-fur­yl)methyl­idene­amino]­imidazolidine-2,4-dione} crys­tallizes as a methanol monosolvate, C8H6N4O5·CH4O. The nitro­furan­toin mol­ecule adopts a nearly planar conformation (r.m.s. deviation = 0.0344 Å). Hydrogen bonds involve the co-operative N—H⋯O—H⋯O heterosynthons between the cyclic imide of nitro­furan­toin and methanol O—H groups. There are also C—H⋯O hydrogen bonds involving the nitro­furan­toin mol­ecules which support the key hydrogen-bonding synthon. The overall crystal packing is further assisted by weak C—H⋯O inter­actions, giving a herringbone pattern

POTENTIAL FOR IMPROVED RELIABILITY AND REDUCED INTERRUPTION COSTS UTILIZING SMART GRID TECHNOLOGIES

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