REVIEW OF IPOMOEA PES-TIGRIDIS L.: ETHNO BOTANICAL CHARACTERISTICS, PHARMACOLOGICAL ACTIVITIES

Nowadays there is a need for scientific justification of plants that have been used in traditional medicine because of loss of information, improvement of therapy and deforestation that is taking place. The majority of the natural products are compounds biosynthetically derived from primary metabolites and are generally categorized as secondary metabolites. These are the major sources of the pharmaceutical industry to discover novel drugs. The basis for interest in natural product chemistry serves as a lead compound for newer drugs, give as much information on possible mechanism and thus on the molecular origin and basis of diseases. Natural products are permanent challenges with respect to total synthesis and stimulate the development of new reagents and reactions. The present study has been taken up to review one of the ethno medicinal significant of Ipomoea pes-tigridis L plant belonging to the family convolvulaceae. The ethno medical information of the plant reveals that the herb Ipomoea pes-tigridis Linn was used as an antidote to dogbite, boils and carbuncles, the leaves were applied as a poultice for boils, carbuncles and sores. The root of this plant was found to possess purgative action. The phytochemical studies on the leaves have been reported for the presence of carbohydrates, proteins and resins

Lutidine Adducts of Co(II) & Ni(II) Dithiophosphinates

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The Inter-Relation of Objective Assessment of The Bell’s Palsy with House-Brackmann Score: A Prospective Study

Introduction: Bell’s palsy is the most common acute peripheral mononeuropathy, which leads to the partial or complete inability to voluntary movement of the facial muscles on the affected side of the face. The study aimed to evaluate the objective assessment of the Bell’s palsy with House-Brackmann score. Methods: This Observational, Prospective study was to be conducted at tertiary care hospital among from June 2022 to September 2022 on 11 patients diagnosed with Bell’s Palsy. A patient’s history includes age, sex, and clinical features. Assessments include facial nerve grading system such as House-Brackmann score, which was used to grade the facial nerve severity. Results: Out of 11 patients, 7 patients of Bell’s Palsy (63%) were reported with Grade IV of House- Brackmann score. The remaining patients were scored under Grade III and Grade V. Patients of age group from 9 to 75 were taken. Among them, age group of 9-40 years were 45% and 40- 80 years were 55%. The result shows that Grade IV is predominant over others, male and elder patients are leading over female and middle- aged patients. 63.7% patient’s clinical features were come under Grade IV of House- Brackmann score. 27.2% of patients had an increased risk of hypertension, 18.1% had Diabetes Mellitus, 18.1% had past history of CVA, 9% had past history of Seizure, and known history of Bell ’s palsy. Conclusion: Using the House-Brackmann grading system, the severity of the patient presenting with Bell’s palsy could be reliably predicted

In-Vitro antiurolithiatic activity of aqueous extract Pavonia lasiopetala

Background: Upto date, the scientific documentation regarding in-vitro antiurolithiatic activity of has been reported, although it has not reported for in-vitro antiurolithiatic activity up till now. Objective: To explore anti-urolithiatic activities of Pavonia lasiopetala leaves extract by utilizing different in-vitro models. Material and Methods: Aqueous extract of Pavonia lasiopetala fresh leaves was prepared and arranged in the different concentrations. Homogenous precipitation method was used to prepare artificial stones such as calcium oxalate and calcium phosphate and semi-permeable membrane of eggs was used as dissolution bags. Dissolution models were incubated in 72 hrs and after that, the entire content in dissolution bags was estimated spectrophotometrically. The inhibitory activity of Pavonia lasiopetala leaves extract on the nucleation of calcium oxalate crystals and the rate of aggregation in calcium oxalate crystals was determined by spectrophotometric assay. Results: In dissolution models, the extract of Pavonia lasiopetala has greater capability to dissolve calcium oxalate while Cystone standard has shown better demineralization for calcium phosphate rather than extract of Pavonia lasiopetala. Cystone exhibited strongly inhibitory action in the nucleation assay rather than aggregation assay. The extract of Pavonia lasiopetala exhibited inhibitory action in both of nucleation and aggregation assays to significant level.  Discussion: Correlation between in-vitro and in-vivo studies may be helpful to understand the molecular mechanism of litholysis process and to reveal phytochemicals of the extract responsible for dissolving or disintegrating renal calculi. Conclusion: Pavonia lasiopetala extract exhibited significant in-vitro anti-urolithiatic activity. Keywords: Pavonia lasiopetala, spectrophotometrically, in-vitro antiurolithiatic

Medicinal plants used by ethnic group Thottianaickans of Semmalai hills (reserved forest), Tiruchirappalli district, Tamil Nadu

245-252The Thottianaickans are a community distributed in various places in Tamil Nadu. During the course of this study, a total of 115 species of medicinal plants distributed among 104 genera belonging to 52 families were listed from the area inhabited by Thottianaickans in the Semalai reserved forest. Usage practices of these plants have also been reported

Synthesis and characterization of Fe- and Co-based ferrite nanoparticles and study of the T-1 and T-2 relaxivity of chitosan-coated particles

In pursuit of newer and more effective contrast agents for magnetic resonance imaging, we report in this article the use of biocompatible chitosan-coated ferrite nanoparticles of different kinds with a view to determine their potential applications as the contrast agents in the field of nuclear magnetic resonance. The single-phase ferrite particles were synthesized by chemical co-precipitation (CoFe2O4 and Fe3O4) and by applying ultrasonic vibration (CoFe2O4 and Co0.8Zn0.2Fe2O4). Although magnetic anisotropy of CoFe2O4 nanoparticle leads to finite coercivity even for nanoensembles, it has been reduced significantly to a minimum level by applying ultrasonic vibration. Fe3O4 synthesized by chemical co-precipitation yielded particles which already possess negligible coercivity and remanence. Substitution of Co by Zn in CoFe2O4 increases the magnetization significantly with a small increase in coercivity and remanence. Particles synthesized by the application of ultrasonic vibration leads to the higher values of T-2 relaxivities than by chemical coprecipitation. We report that the T-2 relaxivities of these particles are of two orders of magnitude higher than corresponding T-1 relaxivities. Thus, these particles are evidently suitable as contrast agent for T-2 weighted MR images