The Research Journey as a Challenge Towards New Trends

The academic community of the department of Risaralda, in its permanent interest in evidencing the results of the research processes that are carried out from the Higher Education Institutions and as a product of the VI meeting of researchers of the department of Risaralda held in November 2021 presents its work: “The journey of research as a challenge towards new trends”, which reflects the result of the latest research and advances in different lines of knowledge in Agricultural Sciences, Health Sciences, Social Sciences and Technology and Information Sciences, which seek to solve and meet the demands of the different sectors. This work would not have been possible without the help of each of the teachers, researchers and authors who presented their articles that make up each of the chapters of the book, to them our gratitude for their commitment, dedication and commitment, since their sole purpose is to contribute from the academy and science to scientific and technological development in the search for the solution of problems and thus contribute to transform the reality of our society and communities. We also wish to extend our gratitude to the institutions of the Network that made this publication possible: UTP, UCP, UNAD, UNIREMINGTON; UNISARC, CIAF, Universidad Libre, Uniclaretiana, Fundación Universitaria Comfamiliar and UNIMINUTO, institutions that in one way or another allowed this work to become a reality, which we hope will be of interest to you.Preface............................................................................................................................7 Chapter 1. Technologies and Engineering Towards a humanization in Engineering using soft skills in training in Engineers.............................................................................................................11 Omar Iván Trejos Buriticá1, Luis Eduardo Muñoz Guerrero Innovative materials in construction: review from a bibliometric analysis....................................................................................................................27 Cristian Osorio Gómez, Daniel Aristizábal Torres, Alejandro Alzate Buitrago, Cristhian Camilo Amariles López Bibliometric review of disaster risk management: progress, trends, and challenges.........................................................................................................51 Alejandro Alzate Buitrago, Gloria Milena Molina Vinasco. Incidence of land coverage and geology, in the unstability of lands of the micro-basin of the Combia creek, Pereira, Risaralda....................................73 Alejandro Alzate Buitrago, Daniel Aristizábal Torres. Chapter 2. Arts, Humanities, and Social Sciences Training experience with teachers teaching mathematics using the inquiry methodology ...............................................................................................95 Vivian Libeth Uzuriaga López, Héctor Gerardo Sánchez Bedoya. Interpretation of the multiple representations of the fears associated to the boarding of limited visual patients in the elective I students’ written productions and low vision ...................................................................................113 Eliana Bermúdez Cardona, Ana María Agudelo Guevara, Caterine Villamarín Acosta. The relevance of local knowledge in social sciences............................................131 Alberto Antonio Berón Ospina, Isabel Cristina Castillo Quintero. Basic education students’ conceptions of conflict a view from the peace for the education....................................................................................................143 Astrid Milena Calderón Cárdenas,Carolina Aguirre Arias, Carolina Franco Ossa, Martha Cecilia Gutiérrez Giraldo, Orfa Buitrago. Comprehensive risk prevention in educational settings: an interdisciplinary and socio-educational approach ............................................................................163 Olga María Henao Trujillo, Claudia María López Ortiz. Chapter 3. Natural and Agricultural Sciences Physicochemical characterization of three substrates used in the deep bedding system in swine .......................................................................................175 Juan Manuel Sánchez Rubio, Andrés Felipe Arias Roldan, Jesús Arturo Rincón Sanz, Jaime Andrés Betancourt Vásquez. Periodic solutions in AFM models........................................................................187 Daniel Cortés Zapata, Alexander Gutiérrez Gutiérrez. Phenology in flower and fruit of Rubus glaucus benth. Cv. Thornless in Risaralda: elements for phytosanitary management .........................................199 Shirley Palacios Castro, Andrés Alfonso Patiño Martínez, James Montoya Lerma, Ricardo Flórez, Harry Josué Pérez. Socio-economic and technical characterization of the cultivation of avocado (Persea americana) in Risaralda..............................................................217 Andrés Alfonso Patiño Martínez, Kelly Saudith Castañez Poveda, Eliana Gómez Correa. Biosecurity management in backyard systems in Santa Rosa de Cabal, Risaralda................................................................................................................227 Julia Victoria Arredondo Botero, Jaiver Estiben Ocampo Jaramillo, Juan Sebastián Mera Vallejo, Álvaro de Jesús Aranzazu Hernández. CONTENTS Physical-chemical diagnosis of soils in hillside areas with predominance of Lulo CV. La Selva production system in the department of Risaralda.............241 Adriana Patricia Restrepo Gallón, María Paula Landinez Montes, Jimena Tobón López. Digestibility of three concentrates used in canine feeding....................................271 María Fernanda Mejía Silva, Valentina Noreña Sánchez, Gastón Adolfo Castaño Jiménez. Chapter 4. Economic, Administrative, and Accounting Sciences Financial inclusion in households from socioeconomic strata 1 and 2 in the city of Pereira ..................................................................................................285 Lindy Neth Perea Mosquera, Marlen Isabel Redondo Ramírez, Angélica Viviana Morales. Internal marketing strategies as a competitive advantage for the company Mobilautos SAS de Dosquebradas........................................................................303 Inés Montoya Sánchez, Sandra Patricia Viana Bolaños, Ana María Barrera Rodríguez. Uses of tourist marketing in the tourist sector of the municipality of Belén de Umbría, Risaralda.............................................................................................319 Ana María Barrera Rodríguez, Paola Andrea Echeverri Gutiérrez, María Camila Parra Buitrago, Paola Andrea Martín Muñoz, Angy Paola Ángel Vélez, Luisa Natalia Trejos Ospina. Territorial prospective of Risaralda department (Colombia), based on the SDGS...............................................................................................................333 Juan Guillermo Gil García, Samanta Londoño Velásquez. Chapter 5. Health and Sports Sciences Performance evaluation in times of pandemic. What do medical students think?.......................................................................................................353 Samuel Eduardo Trujillo Henao, Rodolfo A. Cabrales Vega, Germán Alberto Moreno Gómez. The relevance of the therapist’s self and self-reference in the training of psychologists.....................................................................................................371 Maria Paula Marmolejo Lozano, Mireya Ospina Botero. Habits related to oral health which influence lifestyle of elder people in a wellness center for the elderly in Pereira 2020. .............................................387 Isadora Blanco Pérez, Olga Patricia Ramírez Rodríguez, Ángela María Rincón Hurtado. Analysis of the suicide trend in the Coffee Region in Colombia during the years 2012-2018 ..............................................................................................405 Germán Alberto Moreno Gómez, Jennifer Nessim Salazar, Jairo Franco Londoño, Juan Carlos Medina Osorio. Hind limb long bone fractures in canines and felines...........................................419 María Camila Cruz Vélez, Valentina Herrera Morales, Alba Nydia Restrepo Jiménez, Lina Marcela Palomino, Gabriel Rodolfo Izquierdo Bravo. Prevalence of overweight and obesity in children in the rural and urban area of Risaralda....................................................................................................439 Angela María Álvarez López, Angela Liceth Pérez Rendón, Alejandro Gómez Rodas, Luis Enrique Isaza Velásquez. Chapter 6. Architecture, Design and Advertising The artisan crafts of Risaralda, characteristics, importance, and risks within the Colombian Coffee Cultural Landscape, CCCL....................................457 Yaffa Nahir Ivette Gómez Barrera, Javier Alfonso López Morales

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Gunshot wounds of abdomen: evaluation of stable patients with triple-contrast helical CT

To assess helical computed tomography (CT) with contrast material administered intravenously, orally, and rectally (triple contrast helical CT)) in the prospective evaluation of stable patients with abdominal gunshot wounds in whom there is no clinical indication for immediate exploratory laparotomy. The study was conducted for 19 months. All patients met the following inclusion criteria: age of 16 years or older, hemodynamic stability, no clinical signs of peritoneal irritation, and signed consent to participate. Patients with obvious indications for laparotomy, such as gastrointestinal bleeding or evisceration, were excluded from the study. Forty-seven patients fulfilled the criteria and underwent abdominal triple-contrast helical CT. CT findings were evaluated by one of four radiologists for evidence of peritoneal penetration and injury to solid organs or hollow viscera. Patients were followed up clinically for 13 weeks. CT findings were compared with those at surgery and/or clinical follow-up. CT demonstrated abnormalities in 27 (57%) patients. Laparotomy was performed in 11 (23%) patients; 10 procedures were therapeutic and one was nontherapeutic. The remaining 20 patients had a negative CT scan. These patients were treated conservatively. One injury was missed at CT. For prediction of the need for laparotomy, sensitivity of CT was 96%; specificity, 95%; positive predictive value, 96%; negative predictive value, 95%; and accuracy, 96%. In stable patients with gunshot wounds to the abdomen in whom there is no indication for immediate surgery, triple-contrast helical CT can help reduce the number of cases of unnecessary or nontherapeutic laparotomy (negative laparotomy) and can help identify patients with injuries that may be safely treated without surgery

An Experimental Analysis of Gas Reduction in Multiphase Flow with a KMS Helical Static Mixer

The separation dynamics of a multiphase fluid mixture is studied with the aim to validate the gas reduction from the mixture by means of a KMS helical static mixer device through a laboratory prototype based on the jet-pump artificial lift system for oil extraction. The study is focused on the cyclone phenomenon, produced by the KMS, to experimentally verify the reduction of foaming in a reservoir behaving as a horizontal gravity separator of an oil–gas–water mixture under specific dynamics conditions of velocity and pressure of an incoming streamline, as well as some physical mounting configurations of the device. The results were numerical and experimentally validated, projecting the real performance in three-phase separators in an oil extraction field to improve efficiency in pumping machines regarding the negative effects of the gas. Concerning the gas reduction, a KMS of two elements located at 100 mm from the entrance of the horizontal reservoir and 20 mm from a gas casing tube successfully improves the gas isolation from the mixture, from 29.2% to practically 0% over 200 min in the reservoir, to let oil and water become separated by sedimentation. This gas reduction is indirectly assessed by the emulsion that is generated, which affects the time of oil separation in the counterbalance

An Experimental Analysis of Gas Reduction in Multiphase Flow with a KMS Helical Static Mixer

The separation dynamics of a multiphase fluid mixture is studied with the aim to validate the gas reduction from the mixture by means of a KMS helical static mixer device through a laboratory prototype based on the jet-pump artificial lift system for oil extraction. The study is focused on the cyclone phenomenon, produced by the KMS, to experimentally verify the reduction of foaming in a reservoir behaving as a horizontal gravity separator of an oil–gas–water mixture under specific dynamics conditions of velocity and pressure of an incoming streamline, as well as some physical mounting configurations of the device. The results were numerical and experimentally validated, projecting the real performance in three-phase separators in an oil extraction field to improve efficiency in pumping machines regarding the negative effects of the gas. Concerning the gas reduction, a KMS of two elements located at 100 mm from the entrance of the horizontal reservoir and 20 mm from a gas casing tube successfully improves the gas isolation from the mixture, from 29.2% to practically 0% over 200 min in the reservoir, to let oil and water become separated by sedimentation. This gas reduction is indirectly assessed by the emulsion that is generated, which affects the time of oil separation in the counterbalance

Diplomado en Servicios Públicos Domiciliarios

In the present work, addresses the contemporary view of the concept of domestic public services in Colombia, reviewing the public policies which make the rights of users effective, free competition, socio-environmental responsibility of companies providing public services, inclusion of the criterion of sustainability that is evidenced in aspects such as renewable energies and inclusion of management indicators of high environmental quality for companies providing the public service and finally the particularities of employment regimen in the context of privatization processes. Certainly, the management model for public utilities is in compliance with the regulatory guidelines redesigned in the 1990s and in turn is articulated with the model of sustainable development adopted in the Constitution, allowing the participation of both private capital and public capital for an optimal provision of the service, that responds to the basic principles of universality, low tariffs, continuity of service and efficiency. All of which gives rise to a series of specific legal relationships between the State and the companies that are governed by the concession contracts and by the state's regulatory authority, between the companies and their users, which is guided by uniform conditions contracts and between the companies and their workers with certain peculiarities in the employment regimen.En el presente trabajo aborda una visión contemporánea del concepto de los servicios públicos domiciliarios en Colombia, abordando las políticas públicas que hacen efectivos los derechos que de los usuarios, la libre competencia, la responsabilidad socio ambiental de las empresas prestadoras de servicios públicos, la inclusión del criterio de sostenibilidad que se evidencia en aspectos como energías renovables e inclusión de indicadores de gestión de alta calidad ambiental para las empresas prestadoras del servicio público y finalmente las particularidades de las relaciones laborales en el contexto de los procesos de privatización. Ciertamente, el modelo de gestión de los servicios públicos domiciliarios guarda observancia de las directrices regulatorias rediseñadas en los años noventa y a su vez se articula con el modelo de desarrollo sostenible adoptado en la Constitución Política, permitiendo la participación tanto de capital privado como por capital público para una óptima prestación del servicio que responda a los principios básicos de universalidad, continuidad en la prestación y eficiencia. Todo lo cual, da origen a una serie de relaciones jurídicas específicas entre el Estado con las empresas que se rige por los contratos de concesión y por la facultad regulatoria del Estado, ente las empresas y sus usuarios que se orienta por los contratos de condiciones uniformes y entre las empresas y sus trabajadores con ciertas particularidades en el régimen laboral

ATLANTIC MAMMAL TRAITS: a data set of morphological traits of mammals in the Atlantic Forest of South America

Univ Estadual Paulista, UNESP, Dept Ecol, Inst Biociencias, BR-13506900 Rio Claro, SP, BrazilUniv Fed Santa Catarina, Ctr Ciencias Biol, Dept Ecol & Zool, Florianopolis, SC, Brazil|Caipora Cooperat, Florianopolis, SC, BrazilUniv Estadual Santa Cruz, Programa Posgrad Ecol & Conservac Biodiversidade, Lab Ecol Aplicada Conservacao, Ilheus, BA, BrazilUniv Estadual Santa Cruz, CMARF, Ilheus, BA, BrazilUniv Brasilia, Dept Ecol, Inst Ciencias Biol, Lab Ecol Vertebrados, Brasilia, DF, BrazilUniv Fed Santa Maria, Dept Ecol & Evolut, Santa Maria, RS, BrazilUniv Sao Paulo, Inst Biociencias, Dept Zool, Sao Paulo, SP, BrazilUniv Fed Espirito Santo, Ctr Ciencias Humanas & Nat, Dept Ciencias Biol, Vitoria, ES, BrazilUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Belo Horizonte, MG, BrazilUniv Fed Mato Grosso de Sul, Inst Biociencias, Campo Grande, MS, BrazilUniv Fed Parana, Dept Zool, Curitiba, Parana, BrazilUniv Fed Parana, Programa Posgrad Ecol & Conservcao, Curitiba, Parana, BrazilUniv Estado Rio de Janeiro, Dept Ecol, Rio De Janeiro, RJ, BrazilUniv Estadual Paulista, UNESP, Inst Biociencias, Dept Zool, Rio Claro, SP, BrazilUniv Extremo Sul Catarinense, Programa Posgrad Ciencias Ambientais, Criciuma, SC, BrazilUniv Sao Paulo, ESALQ, Dept Ciencias Biol, Piracicaba, SP, BrazilUniv Nacl Misiones, CONICET, Inst Biol Subtrop, Puerto Iguazu, Misiones, ArgentinaAsociac Civil Ctr Invest Bosque Atlantico, Puerto Iguazu, Misiones, ArgentinaFIOCRUZ Amazonas, Inst Leonidas & Maria Deane, Manaus, Amazonas, BrazilUniv Estadual Paulista, UNESP, Dept Zootecnia, Jaboticabal, SP, BrazilField Museum Nat Hist, Integrated Res Ctr, Chicago, IL 60605 USAUniv Fed Pernambuco, Ctr Biociencias, Dept Zool, Lab Ciencia Aplicada Conservacao Biodiversidade, Recife, PE, BrazilInst Chico Mendes Conservacao Biodiversidade, Ctr Nacl Pesquisa & Conservacao Mamiferos Carnivo, Sao Paulo, BrazilUniv Vale Rio dos Sinos, Sao Leopoldo, RS, BrazilUniv Reg Cariri, Dept Biol, Lab Ecol Mamiferos, Crato, CE, BrazilUniv Fed Rio de Janeiro, Dept Ecol, Lab Vertebrados, Rio De Janeiro, RJ, BrazilUniv Federal Mato Grosso do Sul, Programa Posgrad Ecol & Conservacao, Campo Grande, MS, BrazilIPE, Nazare Paulista, SP, BrazilUniv Fed Minas Gerais, Programa Posgrad Zool, Belo Horizonte, MG, BrazilUniv Estado Minas Gerais, Dept Ciencias Biol, Ibirite, MG, BrazilPREA, Programa Educ Ambiental, Juiz De Fora, MG, BrazilChinese Acad Sci, Inst Zool, Key Lab Zool Systemat and Evolut, Beijing, Peoples R ChinaMinist Salud Nacion, Inst Nacl Med Trop INMeT, Puerto Iguazu, Misiones, ArgentinaUniv Fed Vicosa, Dept Engn Florestal, Vicosa, MG, BrazilUniv Fed Goias, Inst Biociencias, Jatai, Go, BrazilInst Chico Mendes Conservacao Biodiversidade ICMB, Ctr Nacl Pesquisa & Conservacao Primatas Brasilei, Joao Pessoa, PB, BrazilCtr Rescate Fauna Silvestre Guira Oga, Puerto Iguazu, ArgentinaFdn Hist Nat Felix de Azara, Buenos Aires, ArgentinaProjeto Carnivoros Iguacu, Foz Do Iguacu, PR, BrazilUniv Estadual Paulista, Dept Med Vet Prevent & Reprod Anim, Fac Ciencias Agr & Vet Jaboticabal, Jaboticabal, SP, BrazilUniv Fed Integracao Latinoamer, Inst Latinoamer Ciencias Vida & Nat, Foz Do Iguacu, PR, BrazilUniv Fed Sao Paulo, Dept Ciencias Ambientais, Diadema, SP, BrazilUniv Fed Paraiba, Dept Sistemat & Ecol, Lab Mamiferos, Joao Pessoa, Paraiba, BrazilIUCN Peccary Specialist Grp, Campo Grande, MS, BrazilWWF Brazil, Campo Grande, MS, BrazilChicago State Univ, Dept Biol Sci, Chicago, IL USAUniv Fed Rio de Janeiro, Nucleo Ecol & Desenvolvimento Socioambiental Maca, Macae, RJ, BrazilUniv Vila Velha, Programa Posgrad Ecol Ecossistemas, Vila Velha, ES, BrazilUniv Fed Rio de Janeiro, Museu Nacl, Dept Vertebrados, Rio De Janeiro, RJ, BrazilUniv Fed Bahia, Programa Posgrad Ecol, Salvador, BA, BrazilUniv Fed Paraiba, Dept Sistemat & Ecol, Programa Posgrad Ciencias Biol Zool, Lab Mamiferos, Joao Pessoa, Paraiba, BrazilUniv Fed Sao Paulo, Dept Ciencias Ambientais, Diadema, SP, BrazilWeb of Scienc

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in similar to 20% of deceased patients across age groups, and in similar to 1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-alpha 2 or IFN-omega, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals = 70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals = 80 y old for autoantibodies neutralizing IFN-alpha 2 or IFN-omega, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-alpha 2 and IFN-omega. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.GR-F