The Bantu Connective Construction

International audienceThe Bantu equivalent of a genitive construction, a construction in which a nominal constituent modifies another one, is part of a family of constructions commonly called the connective construction. This paper analyses the family of Bantu connective constructions from a perspective inspired by canonical typology. I first define a canonical type and subsequently discuss departures from this type along five dimensions. The resulting picture shows a functionally extremely versatile construction type in a grammatical space that lacks clear-cut boundaries between genitives, adjectives and relative clauses. Connective constructions are a frequent source of lexicalization, and of grammaticalization patterns that often lead to agreement in unusual places

Alternatives for reductionist approaches to comparative Bantu grammar

Studies on most domains of comparative Bantu grammar are typically confronted with a huge amount of data and complex, interacting dimensions of variation. They tend to involve an initial methodological step of reducing this variation by classifying constructions, grammatical properties or entire languages into a finite set of types. This paper argues against such reductionist approaches to linguistic evidence and illustrates several methodological alternatives, one of which is here introduced as the scenario-based approach. I will argue that these alternative approaches are at least as good in managing data and finding generalisations as the reductionist approach, but that they give more reliable results and are better at discovering variation.Les études portant sur la plupart des domaines de la grammaire bantoue comparée sont généralement confrontées à une énorme quantité de données et à des dimensions de variation complexes et interactives. Elles tendent à induire une étape méthodologique initiale de réduction de cette variation en classant les constructions, les propriétés grammaticales ou les langues entières dans un ensemble fini de types. Cet article s'oppose à ces approches réductionnistes des données linguistiques et illustre plusieurs alternatives méthodologiques, dont l'une est présentée ici comme l'approche basée sur des scénarios. Je soutiens que ces approches alternatives sont au moins aussi efficaces pour gérer les données et trouver des généralisations que l'approche réductionniste, mais qu'elles donnent des résultats plus fiables et permettent de mieux mettre en lumière la variation

Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor α (TNF-α) and melphalan in patients with colorectal liver metastases

Background. In this study, we have evaluated hepatotoxicity, secondary cytokine production and hepatic acute-phase response (APR) in patients who underwent isolated hepatic perfusion (IHP) with tumour necrosis factor (TNF) α and melphalan for irresectable colorectal liver metastases. Design. An extracorporeal veno-venous bypass was used to shunt blood from the lower body and intestines to the heart. Inflow catheters were placed in the hepatic artery and portal vein, and an outflow catheter in the inferior caval vein. The liver was perfused for 60 min with 0.4 mg of TNF-α plus 1 mg kg-1 melphalan (IHP(TM) group, n = 6) or 1 mg kg-1 melphalan (IHP(M) group, n = 3). The liver was washed with macrodex before restoring vascular continuity. Results. After the washout procedure, a TNF-α peak (169 ± 38 pg mL-1) was demons

SORTA:a system for ontology-based re-coding and technical annotation of biomedical phenotype data

There is an urgent need to standardize the semantics of biomedical data values, such as phenotypes, to enable comparative and integrative analyses. However, it is unlikely that all studies will use the same data collection protocols. As a result, retrospective standardization is often required, which involves matching of original (unstructured or locally coded) data to widely used coding or ontology systems such as SNOMED CT (clinical terms), ICD-10 (International Classification of Disease) and HPO (Human Phenotype Ontology). This data curation process is usually a time-consuming process performed by a human expert. To help mechanize this process, we have developed SORTA, a computer-aided system for rapidly encoding free text or locally coded values to a formal coding system or ontology. SORTA matches original data values (uploaded in semicolon delimited format) to a target coding system (uploaded in Excel spreadsheet, OWL ontology web language or OBO open biomedical ontologies format). It then semi-automatically shortlists candidate codes for each data value using Lucene and n-gram based matching algorithms, and can also learn from matches chosen by human experts. We evaluated SORTA's applicability in two use cases. For the LifeLines biobank, we used SORTA to recode 90 000 free text values (including 5211 unique values) about physical exercise to MET (Metabolic Equivalent of Task) codes. For the CINEAS clinical symptom coding system, we used SORTA to map to HPO, enriching HPO when necessary (315 terms matched so far). Out of the shortlists at rank 1, we found a precision/recall of 0.97/0.98 in LifeLines and of 0.58/0.45 in CINEAS. More importantly, users found the tool both a major time saver and a quality improvement because SORTA reduced the chances of human mistakes. Thus, SORTA can dramatically ease data (re) coding tasks and we believe it will prove useful for many more projects

Fiscal Centralization, Limited Government, and Public Revenues in Europe, 1650-1913

Old Regime polities typically suffered from fiscal fragmentation and absolutist rule. By the start of World War I, however, many such countries had centralized institutions and limited government. This article uses a new panel data set to perform a statistical analysis of political regimes and public revenues in Europe from 1650 to 1913. Panel regressions indicate that centralized and limited regimes were associated with significantly higher revenues than fragmented and absolutist ones. Structural break tests also suggest close relationships between major turning points in revenue series and political transformations

Innovative technologies for under-resourced language documentation: The BULB Project

International audienceThe project Breaking the Unwritten Language Barrier (BULB), which brings together linguists and computer scientists, aims at supporting linguists in documenting unwritten languages. In order to achieve this we will develop tools tailored to the needs of documentary linguists by building upon technology and expertise from the area of natural language processing, most prominently automatic speech recognition and machine translation. As a development and test bed for this we have chosen three less-resourced African languages from the Bantu family: Basaa, Myene and Embosi. Work within the project is divided into three main steps: 1) Collection of a large corpus of speech (100h per language) at a reasonable cost. After initial recording, the data is re-spoken by a reference speaker to enhance the signal quality and orally translated into French. 2) Automatic transcription of the Bantu languages at phoneme level and the French translation at word level. The recognized Bantu phonemes and French words will then be automatically aligned. 3) Tool development. In close cooperation and discussion with the linguists, the speech and language technologists will design and implement tools that will support the linguists in their work, taking into account the linguists' needs and technology's capabilities. The data collection has begun for the three languages. For this we use standard mobile devices and a dedicated software—LIG-AIKUMA, which proposes a range of different speech collection modes (recording, respeaking, translation and elicitation). LIG-AIKUMA 's improved features include a smart generation and handling of speaker metadata as well as respeaking and parallel audio data mapping

Innovative technologies for under-resourced language documentation: The BULB Project

International audienceThe project Breaking the Unwritten Language Barrier (BULB), which brings together linguists and computer scientists, aims at supporting linguists in documenting unwritten languages. In order to achieve this we will develop tools tailored to the needs of documentary linguists by building upon technology and expertise from the area of natural language processing, most prominently automatic speech recognition and machine translation. As a development and test bed for this we have chosen three less-resourced African languages from the Bantu family: Basaa, Myene and Embosi. Work within the project is divided into three main steps: 1) Collection of a large corpus of speech (100h per language) at a reasonable cost. After initial recording, the data is re-spoken by a reference speaker to enhance the signal quality and orally translated into French. 2) Automatic transcription of the Bantu languages at phoneme level and the French translation at word level. The recognized Bantu phonemes and French words will then be automatically aligned. 3) Tool development. In close cooperation and discussion with the linguists, the speech and language technologists will design and implement tools that will support the linguists in their work, taking into account the linguists' needs and technology's capabilities. The data collection has begun for the three languages. For this we use standard mobile devices and a dedicated software—LIG-AIKUMA, which proposes a range of different speech collection modes (recording, respeaking, translation and elicitation). LIG-AIKUMA 's improved features include a smart generation and handling of speaker metadata as well as respeaking and parallel audio data mapping

Let’s Agree to Disagree on Operative Versus Nonoperative Treatment for Distal Radius Fractures in Older People: Protocol for a Prospective International Multicenter Cohort Study

Background: Distal radius fractures are the most frequently encountered fractures in Western societies, typically affecting patients aged 50 years and older. Although this is a common injury, the best treatment for these fractures in older patients is still under debate. Objective: This prospective study aims to compare the outcome of operatively and nonoperatively treated distal radius fractures in the older population. Only patients with distal radius fractures for which equipoise regarding the optimal treatment exists will be included. Methods: This prospective international multicenter observational cohort study will be designed as a natural experiment. Natural experiments are observational studies in which treatment allocation is determined by factors outside the control of the investigators but also (largely) independent of patient characteristics. Patients aged 65 years and older with an acute distal radius fracture will be considered for inclusion. Treatment allocation (operative vs nonoperative) will be based on the local preferences of the treating hospital either in Switzerland or the Netherlands. Hence, the process governing treatment allocation resembles that of randomization. Patients will be identified after treatment has been initiated. Based on the radiographs and baseline information of the patient, an expert panel of 6 certified trauma surgeons from 2 regions will provide their treatment recommendation. Only patients for whom the experts disagree on treatment recommendations will ultimately be included in the study (ie, for whom there is a clinical equipoise). For these patients, both operative and nonoperative treatment of distal radius fractures are viable, and treatment choice is predominantly determined by personal or local preference. The primary outcome will be the Patient-Rated Wrist Evaluation score at 12 weeks. Secondary outcomes will include the Physical Activity Score for the Elderly, the EQ questionnaire, pain, the living situation, range of motion, complications, and radiological outcomes. By including outcomes such as living situation and the Physical Activity Score for the Elderly, which are not relevant for younger cohorts, valuable information to tailor treatment to the needs of the older population can be gained. According to the sample size collection, which was based on the minimal important clinical difference of the Patient-Rated Wrist Evaluation, 92 patients will have to be included, with at least 46 patients in each treatment group. Results: Enrollment began in July 2023 and is expected to continue until summer 2024. The final follow-up will be 2 years after the last patient is included. Conclusions: Although many trials on this topic have previously been published, there remains an ongoing debate regarding the optimal treatment for distal radius fractures in older patients. This observational study, which will use a fairly new methodological study design, will provide further information on treatment outcomes for older patients with distal radius fractures for which to date equipoise exists regarding the optimal treatment