HCI and Design Research Education

This paper describes the latest insights in HCI education inspired and informed by the creative disciplines, how education is implemented, and how it could be fed back into the artistic fields. It contains examples, contrasts different methods, and discusses and concludes the findings for HCI education in general. A course on HCI is described which is supported by a creative approach, related to art, architecture and music. Experiences are described in of HCI tools and insights such as structured design methods, interaction frameworks and interface design heuristics relevant to the arts fields

Towards a multimodal interaction space: Categorisation and applications

Based on many experiences of developing interactive systems by the authors, a framework for the description and analysis of interaction has been developed. The dimensions of this multimodal interaction space have been identified as sensory modalities, modes and levels of interaction. To illustrate and validate this framework, development of multimodal interaction styles is carried out and interactions in the real world are studied, going from theory to practice and back again. The paper describes the framework and two recent projects, one in the field of interactive architecture and another in the field of multimodal HCI research. Both projects use multiple modalities for interaction, particularly movement based interaction styles. © Springer-Verlag London Limited 2007

Using technology, bioinformatics and health informatics approaches to improve learning experiences in optometry education, research and practice

Rapid advances in ocular diagnostic approaches and emerging links of pathological changes in the eye with systemic disorders have widened the scope of optometry as the front line of eye health care. Expanding professional requirements stipulate that optometry students get a meticulous training in relevant information and communication technologies (ICT) and various bioinformatics and health informatics software to meet current and future challenges. Greater incorporation of ICT approaches in optometry education can facilitate increased student engagement in shared learning experiences and improve collaborative learning. This, in turn, will enable students to participate in and prepare for the complex real-world situations. A judicious use of ICTs by teachers in learning endeavors can help students develop innovative patterns of thinking to be a successful optometry professional. ICT-facilitated learning enables students and professionals to carry out their own research and take initiatives and thus shifts the equilibrium towards self-education. It is important that optometry and allied vision science schools adapt to the changing professional requirements with pedagogical evolution and react appropriately to provide the best educational experience for the students and teachers. This review aims to highlight the scope of ICT applications in optometry education and professional development drawing from similar experiences in other disciplines. Further, while enhanced use of ICT in optometry has the potential to create opportunities for transformative learning experiences, many schools use it merely to reinforce conventional teaching practices. Tremendous developments in ICT should allow educators to consider using ICT tools to enhance communication as well as providing a novel, richer, and more meaningful medium for the comprehensive knowledge construction in optometry and allied health disciplines

Infinite Archives, Infinite Possibilities: Learning Research and Databases with Archive of our Own

This article will discuss the importance of acknowledging the information practices of subcultural groups within library instruction and fostering an inclusive learning environment with the implementation of a workshop by comparing research databases with the popular fanfiction website, Archive of Our Own. By incorporating AO3 into library instruction, students’ interests and prior experiences were engaged by utilizing the principles of subcultural capital. The workshop utilized students’ knowledge of information searching from their personal lives and their interests to highlight similarities with academic research using examples such as filters, keywords, and author searching. This allowed students to develop skills to search precisely for materials in a familiar environment. Further, the success of the workshop demonstrates how librarians can incorporate fan’s informational behaviors, and access practices into instructional content about research and database usage, making research less intimidating and more accessible to students

Impaired energy metabolism: Involvement in neurodegenerative processes and CNS ageing

World is experiencing a consistent and steady increase in the ageing population with even higher proportional differences in the developed countries. Increase in ageing populations is directly correlated with the increased prevalence of age-related degenerative diseases of the central nervous system (CNS) such as Alzheimer’s disease and various other forms of dementias, stroke, Parkinson’s disease, retinal degenerative disorders, Huntington’s’ disease, multiple sclerosis, psychiatric and behavioural disorders amongst others

Advanced spindle runout-roundness separation method

a flexible and accurate method for separating spindle error motion and workpiece roundness is presented. The method makes use of three or more displacement probes. Angle measuring probes can also be used. The angular positions of the probes as well as errors in sensor amplification are determined directly from the measurement data and require no extra measurements. The method can be used for real-time runout measurements with nanometer accuracy

Abundances in Stars from the Red Giant Branch Tip to the Near the Main Sequence in M71: I. Sample Selection, Observing Strategy and Stellar Parameters

We present the sample for an abundance analysis of 25 members of M71 with luminosities ranging from the red giant branch tip to the upper main sequence. The spectra are of high dispersion and of high precision. We describe the observing strategy and determine the stellar parameters for the sample stars using both broad band colors and fits of H$\alpha$ profiles. The derived stellar parameters agree with those from the Yale$^2$ stellar evolutionary tracks to within 50 -- 100K for a fixed log g, which is within the level of the uncertainties.Comment: Minor changes to conform to version accepted for publication, with several new figures (Paper 1 of a pair

Neurale Netwerken in Marketing

Doel van dit artikel is een introductie te geven van neurale netwerken voor diegenen die in marketing of marktonderzoek werkzaam zijn. Eerst wordtingegaan op de (biologische) achtergrond van neurale netwerken. Vervolgens worden diverse aspecten van neurale netwerken besproken: leren aan de hand van voorbeelden, parameters, ‘backpropagalion netwerken’, prototype-gebaseerde netwerken. Daarna wordt een vergeijking getrokken met traditionele statistiek en artificiele intelligentie. Het artikel vervolgt met een discussie over mogelijke toepassingen. Tot slot worden zaken besproken die samenhangen met toepassing in de praktijk, ook omvattend de beschrijving van een aantal beschikbare programma’s

Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.

Cancer cell lines are a cornerstone of cancer research but previous studies have shown that not all cell lines are equal in their ability to model primary tumors. Here we present a comprehensive pan-cancer analysis utilizing transcriptomic profiles from The Cancer Genome Atlas and the Cancer Cell Line Encyclopedia to evaluate cell lines as models of primary tumors across 22 tumor types. We perform correlation analysis and gene set enrichment analysis to understand the differences between cell lines and primary tumors. Additionally, we classify cell lines into tumor subtypes in 9 tumor types. We present our pancreatic cancer results as a case study and find that the commonly used cell line MIA PaCa-2 is transcriptionally unrepresentative of primary pancreatic adenocarcinomas. Lastly, we propose a new cell line panel, the TCGA-110-CL, for pan-cancer studies. This study provides a resource to help researchers select more representative cell line models

Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients.

PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing. We sought to identify specific groups who remain at high risk and evaluate whether they should be offered multi-gene panel testing.MethodsWe tested 300 women on a multi-gene panel who were previously enrolled in a long-term study at UCSF. As part of their long-term care, all previously tested negative for mutations in BRCA1 and BRCA2 either by limited or comprehensive sequencing. Additionally, they met one of the following criteria: (i) personal history of bilateral breast cancer, (ii) personal history of breast cancer and a first or second degree relative with ovarian cancer, and (iii) personal history of ovarian, fallopian tube, or peritoneal carcinoma.ResultsAcross the three groups, 26 women (9%) had a total of 28 pathogenic mutations associated with hereditary cancer susceptibility, and 23 women (8%) had mutations in genes other than BRCA1 and BRCA2. Ashkenazi Jewish and Hispanic women had elevated pathogenic mutation rates. In addition, two women harbored pathogenic mutations in more than one hereditary predisposition gene.ConclusionsAmong women at high risk of breast and ovarian cancer who have previously tested negative for pathogenic BRCA1 and BRCA2 mutations, we identified three groups of women who should be considered for subsequent multi-gene panel testing. The identification of women with multiple pathogenic mutations has important implications for family testing