Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss

PurposeObesity is a multifactorial condition with a relevant genetic correlation. Recent advances in genomic research have identified several single nucleotide polymorphisms (SNPs) in genes such as FTO, MCM6, HLA, and MC4R, associated with obesity. This study aimed to evaluate the association of 102 SNPs with BMI and weight loss treatment response in a multi-ethnic population.MethodsThe study analyzed 9,372 patients for the correlation between SNPs and BMI (dataset A). The correlation between SNP and weight loss was accessed in 474 patients undergoing different treatments (dataset B). Patients in dataset B were further divided into 3 categories based on the type of intervention: dietary therapy, intragastric balloon procedures, or surgeries. SNP association analysis and multiple models of inheritance were performed.ResultsIn dataset A, ten SNPs, including rs9939609 (FTO), rs4988235 (MCM6), and rs2395182 (HLA), were significantly associated with increased BMI. Additionally, other four SNPs, rs7903146 (TCF7L2), (rs6511720), rs5400 (SLC2A2), and rs7498665 (SH2B1), showed sex-specific correlation. For dataset B, SNPs rs2016520 (PPAR-Delta) and rs2419621 (ACSL5) demonstrated significant correlation with weight loss for all treatment types. In patients who adhered to dietary therapy, SNPs rs6544713 (ABCG8) and rs762551 (CYP1A2) were strongly correlated with weight loss. Patients undergoing surgical or endoscopic procedures exhibited differential correlations with several SNPs, including rs1801725 (CASR) and rs12970134 (MC4R), and weight loss.ConclusionThis study provides valuable insights into the genetic factors influencing BMI and weight loss response to different treatments. The findings highlight the potential for personalized weight management approaches based on individual genetic profiles

Desarrollo de herramientas críticas e instrumentales y diseño de recursos educativos en abierto en torno al cómic

El cómic funciona como hilo conductor temático del proyecto, empleando las nuevas tecnologías y la teoría crítica de manera instrumental. cuenta con una triple vertiente: formación de estudiantes, formación de docentes y futuros docentes, y transferencia de resultados. Esta triple vertiente se desarrolla a través de tres ejes: (1) Club de lectura de cómic autogestionado por estudiantes, bajo el título «Narrativas éticas para repensar el mundo»; (2) Talleres instrumentales, teoría crítica y empleabilidad para estudiantes del club y el resto de la comunidad universitaria y un encuentro con una autora; (3) Realización de contenidos en abierto —podcasts,— con los resultados del aprendizaje en los ejes (1) y (2)

Tracheal oxalosis associated with Aspergillus niger tracheobronchitis

Peer reviewe

Genetic Characterization of Extensively Drug-Resistant Shigella sonnei Infections, Spain, 2021-2022

In 2022, the United Kingdom reported an increase in drug resistance in Shigella sonnei isolates. We report 33 cases in Spain genetically related to the UK cases and 4 cases with similar antimicrobial resistance profiles infected with genetically distant strains. Our results suggest circulation of multiple genetic clusters of multidrug-resistant S. sonnei in Spain.Financial support for this work came from the National Institute of Health Carlos III with the project Acción Estratégica de Salud Intramural (AESI; PI21CIII/00029).S

Ethic narratives for rethinking the world: didactic open resources, workshops and graphic narratives reading club

Este proyecto de innovación docente, continuación del proyecto Innova 117 (2020-21), da visibilidad al medio del cómic y a su estudio en el contexto universitario a través de actividades didácticas y formativas dirigidas al estudiantado y al profesorado de las facultades de Filología y Educación. Incluye un club de lectura de cómic de contenido ético enmarcado en los principios de la Agenda 2030, una serie de talleres críticos impartidos por investigadores y estudiantes y varios talleres instrumentales de edición de audio, traducción y didáctica. El proyecto tiene como objetivos principales fomentar el aprendizaje creativo, colaborativo, horizontal y entre pares.This teaching innovation project, which is the continuation of the former innovation project 117 (2020-21), focuses on comics and their study in the university context through didactic and training activities addressed to students and staff of the Faculty of Philology and Education. It includes a reading club (comics with ethic content that breach some of the principles included in the Agenda 2030), several workshops of applied critical theory (taught by students and staff) and several instrumental workshops on audio edition, translation and didactic. One of the main objectives is fostering creative, collaborative and peer-to-peer learning.Depto. de Estudios Ingleses: Lingüística y LiteraturaDepto. de Estudios Románicos, Franceses, Italianos y TraducciónFac. de FilologíaFALSEVicerrectorado de Calidadsubmitte