97 research outputs found
Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis.
Mutations of the Ectodysplasin-A (EDA) gene are generally associated with the syndrome hypohidrotic ectodermal dysplasia (MIM 305100), but they can also manifest as selective, non-syndromic tooth agenesis (MIM300606). We have performed an in vitro functional analysis of six selective tooth agenesis-causing EDA mutations (one novel and five known) that are located in the C-terminal tumor necrosis factor homology domain of the protein. Our study reveals that expression, receptor binding or signaling capability of the mutant EDA1 proteins is only impaired in contrast to syndrome-causing mutations, which we have previously shown to abolish EDA1 expression, receptor binding or signaling. Our results support a model in which the development of the human dentition, especially of anterior teeth, requires the highest level of EDA-receptor signaling, whereas other ectodermal appendages, including posterior teeth, have less stringent requirements and form normally in response to EDA mutations with reduced activity
The role of peptides in bone healing and regeneration: A systematic review
Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited. Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge
Portfolio of prospective clinical trials including brachytherapy: an analysis of the ClinicalTrials.gov database
Langzeitergebnisse nach Trabekulektomie kombiniert mit Mitomycin C und einem Ologen-Implantat
Vergleichsstudie zwischen Kanaloplastik ab Externo und Trabekulektomie mit MMC 0.02% und Ologen bei primärem Offenwinkelglaukom. Eine retrospektive Studie mit 12 Monaten Nachbeobachtungszeit
Retrospektive Verlgleichsstudie und Ergebnisse zwischen zwei Mikrokathetersytemen bei Kanaloplastik ab externo
Langzeitergebnisse nach Trabekulektomie kombiniert mit Mitomycin C und einem Ologen-Implantat
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