8 research outputs found
'Why should I send my child to school?': A study of Burundian Hutu refugees' experiences of exclusion from education and how this motivates education in Tanzanian exile
Unfitness to plead in England and Wales: Historical development and contemporary dilemmas
Isolation of cardiac myosin light-chain isotypes by chromatofocusing. Comparison of human cardiac atrial light-chain 1 and foetal ventricular light-chain 1
Quantification of Quaternary Structure Stability in Aggregation-Prone Proteins under Physiological Conditions: The Transthyretin Case
Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
It remains poorly understood whether and how chaperones control protein evolution. Here the authors show how the chaperone Hsp90 shapes the sequence space of its client, poliovirus protein P1, at the polypeptide and RNA level to balance the evolutionary trade-offs between protein stability, aggregation and translation rate