Situational and Emotional Influences on the Acceptability of Wolf Management Actions

Abstract This article examined the effectiveness of situational and emotional variables in predicting the acceptability of wolf management actions in the Greater Yellowstone Ecosystem. Three hypotheses were advanced: (a) both situational and emotional variables will influence acceptability ratings, (b) emotions will explain the largest proportion of variance for the lethal management action, and (c) this pattern of findings will be the same for residents and visitors. Data were obtained from a survey of local residents and a survey of visitors to Grand Teton National Park. Two situational variables (location of encounter, wolf status) and three emotional variables (sympathy for ranchers, sympathy for wolves, anger about wolves) were included as independent variables. The dependent variables were acceptability of non-lethal and lethal management. Regression analyses supported the hypotheses. While debates regarding wolves are likely to continue, these findings highlight the role that emotion plays in evaluating the acceptability of management actions

Information sources and knowledge about chronic wasting disease in Colorado and Wisconsin

This research note examines hunters' and non-hunters' information sources and knowledge about chronic wasting disease (CWD). Data were obtained from surveys of and Wisconsin (n = 360

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Human-wildlife interactions and the Potential for Conflict Index

Determine acceptability of management actions in scenarios varying by severity of human-wildlife interaction and species involved, using the Potential for Conflict Index and Analysis of VarianceCollege Honors

All-terrain vehicle use:a value-norm-perception model predicting perceived impact on coastal dunes

Coastal dunes are sensitive to human pressure, even at low use levels. With the increase of all-terrain vehicle (ATV) use on dunes and the impacts associated with trampling dune vegetation, ATVs have become a primary concern for land managers charged with coastal protection. To better understand the situation, this article examined the relationships among ATV users': (a) general value orientations (i.e., mutualism and domination, (b) norms (i.e., Awareness of Consequences, AC, and Ascription of Responsibility, AR), and (c) perceived impacts on coastal sand dunes. The two norms constructs were predicted to mediate the relationship between general value orientations and perceived impacts. Data were obtained from a systematic random sample of ATV users in the three communities in rural Canada (n = 97). Results indicated that mutualism was positively related to AC and AR and domination was negatively related to AC. Domination and AC were related to perceived impacts on coastal sand dunes. None of the other predicted relationships, however, were statistically significant

Incorporating Measures of Community in Wildland Fire Preparedness Education

Using data from a survey of Colorado residents, we examined measures of sense of community (SOC). Respondents were asked to rate fifteen items measuring SOC on a 7-point scale, where 1 = strongly disagree and 7 = strongly agree. McMillan and Chavis (1986) suggest that these items form four dimensions of SOC: membership, influence, reinforcement of needs, and shared emotional connection. The four dimensions of SOC were supported by the data (i.e., Cronbach’s alpha \u3e .80 for all four dimensions). A cluster analysis of the four dimensions of SOC identified three distinct segments of individuals. The first cluster indicated that they felt a strong SOC on all four dimensions. The second cluster felt a more neutral SOC, while the third cluster felt a low SOC on all four dimensions. We hypothesize that individuals with a low SOC will not be as likely to adopt wildfire protection (i.e., defensible space) behaviors. Understanding these segments can help inform future wildland fire educational materials